Summary | |
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Symbol | NFASC |
Name | neurofascin |
Aliases | NRCAML; KIAA0756; FLJ46866; NF; neurofascin homolog (chicken); neurofascin homolog |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Domain |
PF13882 Bravo-like intracellular region PF00041 Fibronectin type III domain PF07679 Immunoglobulin I-set domain PF00047 Immunoglobulin domain |
Function |
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. |
Biological Process |
GO:0002175 protein localization to paranode region of axon GO:0006612 protein targeting to membrane GO:0007009 plasma membrane organization GO:0007043 cell-cell junction assembly GO:0007272 ensheathment of neurons GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007422 peripheral nervous system development GO:0008366 axon ensheathment GO:0010927 cellular component assembly involved in morphogenesis GO:0019226 transmission of nerve impulse GO:0021700 developmental maturation GO:0030913 paranodal junction assembly GO:0032288 myelin assembly GO:0034113 heterotypic cell-cell adhesion GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0035637 multicellular organismal signaling GO:0042551 neuron maturation GO:0042552 myelination GO:0045161 neuronal ion channel clustering GO:0045162 clustering of voltage-gated sodium channels GO:0045216 cell-cell junction organization GO:0048469 cell maturation GO:0048667 cell morphogenesis involved in neuron differentiation GO:0050808 synapse organization GO:0061564 axon development GO:0071205 protein localization to juxtaparanode region of axon GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0072661 protein targeting to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:0097485 neuron projection guidance GO:0099612 protein localization to axon GO:1990778 protein localization to cell periphery |
Molecular Function |
GO:0086080 protein binding involved in heterotypic cell-cell adhesion GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion |
Cellular Component |
GO:0005902 microvillus GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0030424 axon GO:0033010 paranodal junction GO:0033267 axon part GO:0033268 node of Ranvier GO:0033270 paranode region of axon GO:0043194 axon initial segment GO:0043209 myelin sheath GO:0044304 main axon GO:0097386 glial cell projection GO:0097454 Schwann cell microvillus GO:0098858 actin-based cell projection |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) |
Reactome |
R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-445095: Interaction between L1 and Ankyrins R-HSA-373760: L1CAM interactions R-HSA-447043: Neurofascin interactions R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | NFASC |
Name | neurofascin |
Aliases | NRCAML; KIAA0756; FLJ46866; NF; neurofascin homolog (chicken); neurofascin homolog |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NFASC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | NFASC |
Name | neurofascin |
Aliases | NRCAML; KIAA0756; FLJ46866; NF; neurofascin homolog (chicken); neurofascin homolog |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NFASC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NFASC |
Name | neurofascin |
Aliases | NRCAML; KIAA0756; FLJ46866; NF; neurofascin homolog (chicken); neurofascin homolog |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NFASC in various data sets.
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Points in the above scatter plot represent the mutation difference of NFASC in various data sets.
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Summary | |
---|---|
Symbol | NFASC |
Name | neurofascin |
Aliases | NRCAML; KIAA0756; FLJ46866; NF; neurofascin homolog (chicken); neurofascin homolog |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NFASC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NFASC |
Name | neurofascin |
Aliases | NRCAML; KIAA0756; FLJ46866; NF; neurofascin homolog (chicken); neurofascin homolog |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NFASC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NFASC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NFASC |
Name | neurofascin |
Aliases | NRCAML; KIAA0756; FLJ46866; NF; neurofascin homolog (chicken); neurofascin homolog |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NFASC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NFASC |
Name | neurofascin |
Aliases | NRCAML; KIAA0756; FLJ46866; NF; neurofascin homolog (chicken); neurofascin homolog |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NFASC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NFASC |
Name | neurofascin |
Aliases | NRCAML; KIAA0756; FLJ46866; NF; neurofascin homolog (chicken); neurofascin homolog |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NFASC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |