Summary | |
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Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Note=Nuclear distribution increases under hypertonic conditions. |
Domain |
PF16179 Rel homology dimerisation domain PF00554 Rel homology DNA-binding domain |
Function |
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). |
Biological Process |
GO:0006970 response to osmotic stress GO:0007588 excretion GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0033173 calcineurin-NFAT signaling cascade GO:0048016 inositol phosphate-mediated signaling GO:0050848 regulation of calcium-mediated signaling GO:0070884 regulation of calcineurin-NFAT signaling cascade GO:0097720 calcineurin-mediated signaling |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NFAT5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NFAT5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NFAT5 in various data sets.
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Points in the above scatter plot represent the mutation difference of NFAT5 in various data sets.
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Summary | |
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Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NFAT5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NFAT5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NFAT5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NFAT5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NFAT5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NFAT5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NFAT5 |
Name | nuclear factor of activated T-cells 5, tonicity-responsive |
Aliases | TONEBP; KIAA0827; NFATL1; OREBP; NFATZ; NF-AT5; NFAT-like protein 1; T-cell transcription factor NFAT5; TonE ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NFAT5 collected from DrugBank database. |
There is no record. |