Summary | |
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Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
Domain |
PF16179 Rel homology dimerisation domain PF00554 Rel homology DNA-binding domain |
Function |
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. |
Biological Process |
GO:0001525 angiogenesis GO:0001569 patterning of blood vessels GO:0001763 morphogenesis of a branching structure GO:0001819 positive regulation of cytokine production GO:0006091 generation of precursor metabolites and energy GO:0007389 pattern specification process GO:0007507 heart development GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010226 response to lithium ion GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0015980 energy derivation by oxidation of organic compounds GO:0016055 Wnt signaling pathway GO:0016358 dendrite development GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0021700 developmental maturation GO:0022604 regulation of cell morphogenesis GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0031345 negative regulation of cell projection organization GO:0032091 negative regulation of protein binding GO:0032640 tumor necrosis factor production GO:0032680 regulation of tumor necrosis factor production GO:0032760 positive regulation of tumor necrosis factor production GO:0033173 calcineurin-NFAT signaling cascade GO:0034644 cellular response to UV GO:0035239 tube morphogenesis GO:0035561 regulation of chromatin binding GO:0035562 negative regulation of chromatin binding GO:0042692 muscle cell differentiation GO:0043393 regulation of protein binding GO:0045333 cellular respiration GO:0045665 negative regulation of neuron differentiation GO:0048016 inositol phosphate-mediated signaling GO:0048167 regulation of synaptic plasticity GO:0048514 blood vessel morphogenesis GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048754 branching morphogenesis of an epithelial tube GO:0048813 dendrite morphogenesis GO:0048814 regulation of dendrite morphogenesis GO:0050768 negative regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0050774 negative regulation of dendrite morphogenesis GO:0050803 regulation of synapse structure or activity GO:0050804 modulation of synaptic transmission GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051145 smooth muscle cell differentiation GO:0051961 negative regulation of nervous system development GO:0055001 muscle cell development GO:0060074 synapse maturation GO:0060562 epithelial tube morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061614 pri-miRNA transcription from RNA polymerase II promoter GO:0071214 cellular response to abiotic stimulus GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071285 cellular response to lithium ion GO:0071478 cellular response to radiation GO:0071482 cellular response to light stimulus GO:0071706 tumor necrosis factor superfamily cytokine production GO:0090128 regulation of synapse maturation GO:0097193 intrinsic apoptotic signaling pathway GO:0097720 calcineurin-mediated signaling GO:0198738 cell-cell signaling by wnt GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:2000171 negative regulation of dendrite development GO:2000297 negative regulation of synapse maturation GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003713 transcription coactivator activity GO:0008134 transcription factor binding GO:0042975 peroxisome proliferator activated receptor binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0045111 intermediate filament cytoskeleton |
KEGG |
hsa04022 cGMP-PKG signaling pathway hsa04310 Wnt signaling pathway hsa04360 Axon guidance hsa04921 Oxytocin signaling pathway |
Reactome | - |
Summary | |
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Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NFATC4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NFATC4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NFATC4 in various data sets.
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Points in the above scatter plot represent the mutation difference of NFATC4 in various data sets.
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Summary | |
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Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NFATC4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NFATC4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NFATC4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NFATC4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NFATC4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NFATC4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NFATC4 |
Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Aliases | NFAT3; NF-AT3; NF-ATC4; T-cell transcription factor NFAT3; Nuclear factor of activated T-cells, cytoplasmic ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NFATC4 collected from DrugBank database. |
There is no record. |