Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents. |
Domain |
PF03131 bZIP Maf transcription factor |
Function |
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0000303 response to superoxide GO:0000305 response to oxygen radical GO:0001525 angiogenesis GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0002244 hematopoietic progenitor cell differentiation GO:0002683 negative regulation of immune system process GO:0006575 cellular modified amino acid metabolic process GO:0006749 glutathione metabolic process GO:0006750 glutathione biosynthetic process GO:0006790 sulfur compound metabolic process GO:0006801 superoxide metabolic process GO:0006979 response to oxidative stress GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0007568 aging GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009267 cellular response to starvation GO:0009636 response to toxic substance GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010498 proteasomal protein catabolic process GO:0010499 proteasomal ubiquitin-independent protein catabolic process GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010656 negative regulation of muscle cell apoptotic process GO:0010657 muscle cell apoptotic process GO:0010658 striated muscle cell apoptotic process GO:0010659 cardiac muscle cell apoptotic process GO:0010660 regulation of muscle cell apoptotic process GO:0010662 regulation of striated muscle cell apoptotic process GO:0010664 negative regulation of striated muscle cell apoptotic process GO:0010665 regulation of cardiac muscle cell apoptotic process GO:0010667 negative regulation of cardiac muscle cell apoptotic process GO:0010720 positive regulation of cell development GO:0010827 regulation of glucose transport GO:0010828 positive regulation of glucose transport GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014812 muscle cell migration GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014912 negative regulation of smooth muscle cell migration GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0019184 nonribosomal peptide biosynthetic process GO:0019430 removal of superoxide radicals GO:0030193 regulation of blood coagulation GO:0030194 positive regulation of blood coagulation GO:0030335 positive regulation of cell migration GO:0030336 negative regulation of cell migration GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0030968 endoplasmic reticulum unfolded protein response GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031346 positive regulation of cell projection organization GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0034248 regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0034405 response to fluid shear stress GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0034614 cellular response to reactive oxygen species GO:0034616 response to laminar fluid shear stress GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035690 cellular response to drug GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0036473 cell death in response to oxidative stress GO:0036474 cell death in response to hydrogen peroxide GO:0036499 PERK-mediated unfolded protein response GO:0036503 ERAD pathway GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0042149 cellular response to glucose starvation GO:0042176 regulation of protein catabolic process GO:0042398 cellular modified amino acid biosynthetic process GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0042594 response to starvation GO:0042762 regulation of sulfur metabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0044272 sulfur compound biosynthetic process GO:0045454 cell redox homeostasis GO:0045666 positive regulation of neuron differentiation GO:0045732 positive regulation of protein catabolic process GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045862 positive regulation of proteolysis GO:0045995 regulation of embryonic development GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046326 positive regulation of glucose import GO:0048514 blood vessel morphogenesis GO:0048863 stem cell differentiation GO:0050769 positive regulation of neurogenesis GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050820 positive regulation of coagulation GO:0050878 regulation of body fluid levels GO:0051176 positive regulation of sulfur metabolic process GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051962 positive regulation of nervous system development GO:0060218 hematopoietic stem cell differentiation GO:0061041 regulation of wound healing GO:0061136 regulation of proteasomal protein catabolic process GO:0070301 cellular response to hydrogen peroxide GO:0070482 response to oxygen levels GO:0071356 cellular response to tumor necrosis factor GO:0071450 cellular response to oxygen radical GO:0071451 cellular response to superoxide GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071496 cellular response to external stimulus GO:0071498 cellular response to fluid shear stress GO:0071499 cellular response to laminar fluid shear stress GO:0072577 endothelial cell apoptotic process GO:0072593 reactive oxygen species metabolic process GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090303 positive regulation of wound healing GO:0090322 regulation of superoxide metabolic process GO:0097193 intrinsic apoptotic signaling pathway GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1900046 regulation of hemostasis GO:1900048 positive regulation of hemostasis GO:1900407 regulation of cellular response to oxidative stress GO:1900408 negative regulation of cellular response to oxidative stress GO:1901031 regulation of response to reactive oxygen species GO:1901032 negative regulation of response to reactive oxygen species GO:1901342 regulation of vasculature development GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901532 regulation of hematopoietic progenitor cell differentiation GO:1901533 negative regulation of hematopoietic progenitor cell differentiation GO:1901800 positive regulation of proteasomal protein catabolic process GO:1902036 regulation of hematopoietic stem cell differentiation GO:1902037 negative regulation of hematopoietic stem cell differentiation GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1902882 regulation of response to oxidative stress GO:1902883 negative regulation of response to oxidative stress GO:1903034 regulation of response to wounding GO:1903036 positive regulation of response to wounding GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process GO:1903201 regulation of oxidative stress-induced cell death GO:1903202 negative regulation of oxidative stress-induced cell death GO:1903205 regulation of hydrogen peroxide-induced cell death GO:1903206 negative regulation of hydrogen peroxide-induced cell death GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903786 regulation of glutathione biosynthetic process GO:1903788 positive regulation of glutathione biosynthetic process GO:1904018 positive regulation of vasculature development GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904036 negative regulation of epithelial cell apoptotic process GO:1904292 regulation of ERAD pathway GO:1904294 positive regulation of ERAD pathway GO:1904738 vascular associated smooth muscle cell migration GO:1904752 regulation of vascular associated smooth muscle cell migration GO:1904753 negative regulation of vascular associated smooth muscle cell migration GO:1990748 cellular detoxification GO:2000121 regulation of removal of superoxide radicals GO:2000146 negative regulation of cell motility GO:2000147 positive regulation of cell motility GO:2000351 regulation of endothelial cell apoptotic process GO:2000352 negative regulation of endothelial cell apoptotic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000736 regulation of stem cell differentiation GO:2000737 negative regulation of stem cell differentiation GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001158 enhancer sequence-specific DNA binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001221 transcription cofactor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0008134 transcription factor binding GO:0033613 activating transcription factor binding GO:0035326 enhancer binding |
Cellular Component |
GO:0000785 chromatin GO:0005813 centrosome GO:0032993 protein-DNA complex |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome | - |
Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NFE2L2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NFE2L2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NFE2L2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NFE2L2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NFE2L2 in various data sets.
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Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NFE2L2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NFE2L2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NFE2L2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NFE2L2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NFE2L2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NFE2L2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NFE2L2 |
Name | nuclear factor, erythroid 2-like 2 |
Aliases | NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ...... |
Chromosomal Location | 2q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NFE2L2 collected from DrugBank database. |
There is no record. |