Summary | |
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Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00859 CTF/NF-I family transcription modulation region PF03165 MH1 domain PF10524 Nuclear factor I protein pre-N-terminus |
Function |
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
Biological Process |
GO:0006260 DNA replication GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-749476: RNA Polymerase III Abortive And Retractive Initiation R-HSA-74158: RNA Polymerase III Transcription R-HSA-73980: RNA Polymerase III Transcription Termination |
Summary | |
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Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NFIC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NFIC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NFIC in various data sets.
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Points in the above scatter plot represent the mutation difference of NFIC in various data sets.
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Summary | |
---|---|
Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NFIC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NFIC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NFIC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NFIC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NFIC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NFIC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NFIC |
Name | nuclear factor I/C (CCAAT-binding transcription factor) |
Aliases | NF-I; CTF5; NFI; NF-I/C; NF1-C; NFI-C; Nuclear factor I/C; Nuclear factor 1/C; Nuclear factor 1 C-type |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NFIC collected from DrugBank database. |
There is no record. |