Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF07716 Basic region leucine zipper PF06529 Vertebrate interleukin-3 regulated transcription factor |
Function |
Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). |
Biological Process |
GO:0007623 circadian rhythm GO:0048511 rhythmic process GO:0070670 response to interleukin-4 GO:0071353 cellular response to interleukin-4 |
Molecular Function |
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003714 transcription corepressor activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1368108: BMAL1 R-HSA-400253: Circadian Clock |
Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NFIL3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NFIL3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NFIL3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NFIL3 in various data sets.
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Points in the above scatter plot represent the mutation difference of NFIL3 in various data sets.
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Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NFIL3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NFIL3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NFIL3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NFIL3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NFIL3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NFIL3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NFIL3 |
Name | nuclear factor, interleukin 3 regulated |
Aliases | E4BP4; NFIL3A; NF-IL3A; IL3BP1; NF-IL3AA; E4 promoter-binding protein 4; interleukin-3 promoter transcriptio ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NFIL3 collected from DrugBank database. |
There is no record. |