Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). |
Domain |
PF00023 Ankyrin repeat PF12796 Ankyrin repeats (3 copies) PF00531 Death domain PF16179 Rel homology dimerisation domain PF00554 Rel homology DNA-binding domain |
Function |
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. |
Biological Process |
GO:0000271 polysaccharide biosynthetic process GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0005976 polysaccharide metabolic process GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006066 alcohol metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0006694 steroid biosynthetic process GO:0006766 vitamin metabolic process GO:0006775 fat-soluble vitamin metabolic process GO:0006869 lipid transport GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0008202 steroid metabolic process GO:0009110 vitamin biosynthetic process GO:0009612 response to mechanical stimulus GO:0010586 miRNA metabolic process GO:0010742 macrophage derived foam cell differentiation GO:0010743 regulation of macrophage derived foam cell differentiation GO:0010744 positive regulation of macrophage derived foam cell differentiation GO:0010876 lipid localization GO:0010883 regulation of lipid storage GO:0010884 positive regulation of lipid storage GO:0010894 negative regulation of steroid biosynthetic process GO:0010956 negative regulation of calcidiol 1-monooxygenase activity GO:0010957 negative regulation of vitamin D biosynthetic process GO:0015850 organic hydroxy compound transport GO:0015918 sterol transport GO:0016051 carbohydrate biosynthetic process GO:0016055 Wnt signaling pathway GO:0019216 regulation of lipid metabolic process GO:0019218 regulation of steroid metabolic process GO:0019915 lipid storage GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030203 glycosaminoglycan metabolic process GO:0030212 hyaluronan metabolic process GO:0030213 hyaluronan biosynthetic process GO:0030301 cholesterol transport GO:0030656 regulation of vitamin metabolic process GO:0031098 stress-activated protein kinase signaling cascade GO:0031293 membrane protein intracellular domain proteolysis GO:0031348 negative regulation of defense response GO:0031349 positive regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0032368 regulation of lipid transport GO:0032369 negative regulation of lipid transport GO:0032371 regulation of sterol transport GO:0032372 negative regulation of sterol transport GO:0032374 regulation of cholesterol transport GO:0032375 negative regulation of cholesterol transport GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032496 response to lipopolysaccharide GO:0032606 type I interferon production GO:0032615 interleukin-12 production GO:0032655 regulation of interleukin-12 production GO:0032695 negative regulation of interleukin-12 production GO:0032768 regulation of monooxygenase activity GO:0032769 negative regulation of monooxygenase activity GO:0032881 regulation of polysaccharide metabolic process GO:0032885 regulation of polysaccharide biosynthetic process GO:0033619 membrane protein proteolysis GO:0035094 response to nicotine GO:0035994 response to muscle stretch GO:0038061 NIK/NF-kappaB signaling GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0042035 regulation of cytokine biosynthetic process GO:0042036 negative regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042090 interleukin-12 biosynthetic process GO:0042107 cytokine metabolic process GO:0042359 vitamin D metabolic process GO:0042362 fat-soluble vitamin biosynthetic process GO:0042368 vitamin D biosynthetic process GO:0043255 regulation of carbohydrate biosynthetic process GO:0043279 response to alkaloid GO:0043331 response to dsRNA GO:0043434 response to peptide hormone GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0045075 regulation of interleukin-12 biosynthetic process GO:0045083 negative regulation of interleukin-12 biosynthetic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045833 negative regulation of lipid metabolic process GO:0045913 positive regulation of carbohydrate metabolic process GO:0045939 negative regulation of steroid metabolic process GO:0046137 negative regulation of vitamin metabolic process GO:0046165 alcohol biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050810 regulation of steroid biosynthetic process GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0051051 negative regulation of transport GO:0051055 negative regulation of lipid biosynthetic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051235 maintenance of location GO:0051341 regulation of oxidoreductase activity GO:0051354 negative regulation of oxidoreductase activity GO:0051403 stress-activated MAPK cascade GO:0060070 canonical Wnt signaling pathway GO:0060556 regulation of vitamin D biosynthetic process GO:0060558 regulation of calcidiol 1-monooxygenase activity GO:0060828 regulation of canonical Wnt signaling pathway GO:0070555 response to interleukin-1 GO:0070741 response to interleukin-6 GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071260 cellular response to mechanical stimulus GO:0071312 cellular response to alkaloid GO:0071316 cellular response to nicotine GO:0071347 cellular response to interleukin-1 GO:0071354 cellular response to interleukin-6 GO:0071359 cellular response to dsRNA GO:0071375 cellular response to peptide hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071496 cellular response to external stimulus GO:0090077 foam cell differentiation GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt GO:1900125 regulation of hyaluronan biosynthetic process GO:1900127 positive regulation of hyaluronan biosynthetic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902930 regulation of alcohol biosynthetic process GO:1902931 negative regulation of alcohol biosynthetic process GO:1903510 mucopolysaccharide metabolic process GO:2000628 regulation of miRNA metabolic process GO:2000630 positive regulation of miRNA metabolic process |
Molecular Function |
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001158 enhancer sequence-specific DNA binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0008134 transcription factor binding GO:0035326 enhancer binding GO:0042805 actinin binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0033256 I-kappaB/NF-kappaB complex |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04064 NF-kappa B signaling pathway hsa04066 HIF-1 signaling pathway hsa04071 Sphingolipid signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04210 Apoptosis hsa04380 Osteoclast differentiation hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04668 TNF signaling pathway hsa04722 Neurotrophin signaling pathway hsa04917 Prolactin signaling pathway hsa04920 Adipocytokine signaling pathway |
Reactome |
R-HSA-166054: Activated TLR4 signalling R-HSA-1169091: Activation of NF-kappaB in B cells R-HSA-1280218: Adaptive Immune System R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5621575: CD209 (DC-SIGN) signaling R-HSA-5607764: CLEC7A (Dectin-1) signaling R-HSA-5660668: CLEC7A/inflammasome pathway R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA R-HSA-3134963: DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5602358: Diseases associated with the TLR signaling cascade R-HSA-5260271: Diseases of Immune System R-HSA-202424: Downstream TCR signaling R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2871837: FCERI mediated NF-kB activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-5603027: IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603029: IkBA variant leads to EDA-ID R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-448706: Interleukin-1 processing R-HSA-446652: Interleukin-1 signaling R-HSA-450294: MAP kinase activation in TLR cascade R-HSA-5684264: MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-209560: NF-kB is activated and signals survival R-HSA-6798695: Neutrophil degranulation R-HSA-3214841: PKMTs methylate histone lysines R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-1810476: RIP-mediated NFkB activation via ZBP1 R-HSA-193692: Regulated proteolysis of p75NTR R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-202403: TCR signaling R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-933542: TRAF6 mediated NF-kB activation R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-1606322: ZBP1(DAI) mediated induction of type I IFNs R-HSA-193704: p75 NTR receptor-mediated signalling R-HSA-193639: p75NTR signals via NF-kB |
Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NFKB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NFKB1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NFKB1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NFKB1 in various data sets.
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Points in the above scatter plot represent the mutation difference of NFKB1 in various data sets.
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Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NFKB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NFKB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NFKB1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NFKB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NFKB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NFKB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NFKB1 |
Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Aliases | KBF1; NFKB-p50; NF-kappaB; NFkappaB; NF-kB1; EBP-1; NF-kappa-B; NFKB-p105; DNA binding factor KBF1; DNA-bind ...... |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NFKB1 collected from DrugBank database. |
Details on drugs targeting NFKB1.
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