Summary | |
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Symbol | NID2 |
Name | nidogen 2 (osteonidogen) |
Aliases | NID-2; osteonidogen; Nidogen-2 |
Chromosomal Location | 14q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. |
Domain |
PF12662 Complement Clr-like EGF-like PF12947 EGF domain PF07645 Calcium-binding EGF domain PF07474 G2F domain PF00058 Low-density lipoprotein receptor repeat class B PF06119 Nidogen-like PF00086 Thyroglobulin type-1 repeat |
Function |
Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions. |
Biological Process |
GO:0007160 cell-matrix adhesion GO:0030198 extracellular matrix organization GO:0031589 cell-substrate adhesion GO:0043062 extracellular structure organization GO:0071711 basement membrane organization |
Molecular Function |
GO:0005518 collagen binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0044420 extracellular matrix component |
KEGG | - |
Reactome |
R-HSA-1474244: Extracellular matrix organization R-HSA-3000157: Laminin interactions |
Summary | |
---|---|
Symbol | NID2 |
Name | nidogen 2 (osteonidogen) |
Aliases | NID-2; osteonidogen; Nidogen-2 |
Chromosomal Location | 14q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NID2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NID2 |
Name | nidogen 2 (osteonidogen) |
Aliases | NID-2; osteonidogen; Nidogen-2 |
Chromosomal Location | 14q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NID2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NID2 |
Name | nidogen 2 (osteonidogen) |
Aliases | NID-2; osteonidogen; Nidogen-2 |
Chromosomal Location | 14q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NID2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NID2 in various data sets.
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Summary | |
---|---|
Symbol | NID2 |
Name | nidogen 2 (osteonidogen) |
Aliases | NID-2; osteonidogen; Nidogen-2 |
Chromosomal Location | 14q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NID2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NID2 |
Name | nidogen 2 (osteonidogen) |
Aliases | NID-2; osteonidogen; Nidogen-2 |
Chromosomal Location | 14q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NID2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NID2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NID2 |
Name | nidogen 2 (osteonidogen) |
Aliases | NID-2; osteonidogen; Nidogen-2 |
Chromosomal Location | 14q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NID2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NID2 |
Name | nidogen 2 (osteonidogen) |
Aliases | NID-2; osteonidogen; Nidogen-2 |
Chromosomal Location | 14q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NID2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NID2 |
Name | nidogen 2 (osteonidogen) |
Aliases | NID-2; osteonidogen; Nidogen-2 |
Chromosomal Location | 14q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NID2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |