Summary | |
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Symbol | NINL |
Name | ninein-like |
Aliases | KIAA0980; NLP; ninein-like protein; dJ691N24.1 |
Chromosomal Location | 20p11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm Note=In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex (PubMed:16254247). During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm (PubMed:16254247). |
Domain |
PF13499 EF-hand domain pair |
Function |
Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. |
Biological Process |
GO:0000086 G2/M transition of mitotic cell cycle GO:0000226 microtubule cytoskeleton organization GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition |
Molecular Function | - |
Cellular Component |
GO:0005874 microtubule |
KEGG | - |
Reactome |
R-HSA-8854518: AURKA Activation by TPX2 R-HSA-5620912: Anchoring of the basal body to the plasma membrane R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-380287: Centrosome maturation R-HSA-5617833: Cilium Assembly R-HSA-69275: G2/M Transition R-HSA-380259: Loss of Nlp from mitotic centrosomes R-HSA-380284: Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-453274: Mitotic G2-G2/M phases R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition |
Summary | |
---|---|
Symbol | NINL |
Name | ninein-like |
Aliases | KIAA0980; NLP; ninein-like protein; dJ691N24.1 |
Chromosomal Location | 20p11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NINL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NINL |
Name | ninein-like |
Aliases | KIAA0980; NLP; ninein-like protein; dJ691N24.1 |
Chromosomal Location | 20p11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NINL in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NINL |
Name | ninein-like |
Aliases | KIAA0980; NLP; ninein-like protein; dJ691N24.1 |
Chromosomal Location | 20p11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NINL in various data sets.
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Points in the above scatter plot represent the mutation difference of NINL in various data sets.
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Summary | |
---|---|
Symbol | NINL |
Name | ninein-like |
Aliases | KIAA0980; NLP; ninein-like protein; dJ691N24.1 |
Chromosomal Location | 20p11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NINL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NINL |
Name | ninein-like |
Aliases | KIAA0980; NLP; ninein-like protein; dJ691N24.1 |
Chromosomal Location | 20p11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NINL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NINL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NINL |
Name | ninein-like |
Aliases | KIAA0980; NLP; ninein-like protein; dJ691N24.1 |
Chromosomal Location | 20p11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NINL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NINL |
Name | ninein-like |
Aliases | KIAA0980; NLP; ninein-like protein; dJ691N24.1 |
Chromosomal Location | 20p11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NINL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NINL |
Name | ninein-like |
Aliases | KIAA0980; NLP; ninein-like protein; dJ691N24.1 |
Chromosomal Location | 20p11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NINL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |