Summary | |
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Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00046 Homeobox domain |
Function |
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). |
Biological Process |
GO:0001501 skeletal system development GO:0002062 chondrocyte differentiation GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002066 columnar/cuboidal epithelial cell development GO:0007368 determination of left/right symmetry GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0009799 specification of symmetry GO:0009855 determination of bilateral symmetry GO:0031016 pancreas development GO:0032330 regulation of chondrocyte differentiation GO:0032331 negative regulation of chondrocyte differentiation GO:0042471 ear morphogenesis GO:0042474 middle ear morphogenesis GO:0043583 ear development GO:0048536 spleen development GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048568 embryonic organ development GO:0048645 animal organ formation GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0051216 cartilage development GO:0055123 digestive system development GO:0060575 intestinal epithelial cell differentiation GO:0060576 intestinal epithelial cell development GO:0061035 regulation of cartilage development GO:0061037 negative regulation of cartilage development GO:0061448 connective tissue development GO:0090596 sensory organ morphogenesis |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NKX3-2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NKX3-2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NKX3-2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NKX3-2 in various data sets.
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Summary | |
---|---|
Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NKX3-2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NKX3-2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NKX3-2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NKX3-2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NKX3-2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NKX3-2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NKX3-2 |
Name | NK3 homeobox 2 |
Aliases | NKX3B; NKX3.2; BAPX1; bagpipe homeobox homolog 1 (Drosophila); SMMD; bagpipe homeobox protein homolog 1; hom ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NKX3-2 collected from DrugBank database. |
There is no record. |