Summary | |
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Symbol | NLGN3 |
Name | neuroligin 3 |
Aliases | HNL3; KIAA1480; ASPGX1; AUTSX1; gliotactin homolog; Neuroligin-3 |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Cell junction, synapse Note=Detected at both glutamatergic and GABAergic synapses. |
Domain |
PF00135 Carboxylesterase family |
Function |
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). |
Biological Process |
GO:0001941 postsynaptic membrane organization GO:0002087 regulation of respiratory gaseous exchange by neurological system process GO:0003016 respiratory system process GO:0006898 receptor-mediated endocytosis GO:0007158 neuron cell-cell adhesion GO:0007215 glutamate receptor signaling pathway GO:0007270 neuron-neuron synaptic transmission GO:0007409 axonogenesis GO:0007416 synapse assembly GO:0007585 respiratory gaseous exchange GO:0007611 learning or memory GO:0007612 learning GO:0007632 visual behavior GO:0008306 associative learning GO:0008542 visual learning GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0010001 glial cell differentiation GO:0010469 regulation of receptor activity GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0016049 cell growth GO:0016358 dendrite development GO:0022604 regulation of cell morphogenesis GO:0022898 regulation of transmembrane transporter activity GO:0030534 adult behavior GO:0031345 negative regulation of cell projection organization GO:0032409 regulation of transporter activity GO:0032411 positive regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032414 positive regulation of ion transmembrane transporter activity GO:0034762 regulation of transmembrane transport GO:0034764 positive regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034767 positive regulation of ion transmembrane transport GO:0035176 social behavior GO:0035249 synaptic transmission, glutamatergic GO:0042063 gliogenesis GO:0042391 regulation of membrane potential GO:0043270 positive regulation of ion transport GO:0043576 regulation of respiratory gaseous exchange GO:0044057 regulation of system process GO:0044065 regulation of respiratory system process GO:0044089 positive regulation of cellular component biogenesis GO:0044091 membrane biogenesis GO:0044708 single-organism behavior GO:0045665 negative regulation of neuron differentiation GO:0048167 regulation of synaptic plasticity GO:0048588 developmental cell growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048709 oligodendrocyte differentiation GO:0048813 dendrite morphogenesis GO:0048814 regulation of dendrite morphogenesis GO:0050768 negative regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0050774 negative regulation of dendrite morphogenesis GO:0050803 regulation of synapse structure or activity GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0050806 positive regulation of synaptic transmission GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0050890 cognition GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051703 intraspecies interaction between organisms GO:0051705 multi-organism behavior GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0051963 regulation of synapse assembly GO:0051965 positive regulation of synapse assembly GO:0051966 regulation of synaptic transmission, glutamatergic GO:0051968 positive regulation of synaptic transmission, glutamatergic GO:0060024 rhythmic synaptic transmission GO:0060078 regulation of postsynaptic membrane potential GO:0060079 excitatory postsynaptic potential GO:0060080 inhibitory postsynaptic potential GO:0060291 long-term synaptic potentiation GO:0060560 developmental growth involved in morphogenesis GO:0060996 dendritic spine development GO:0060997 dendritic spine morphogenesis GO:0060998 regulation of dendritic spine development GO:0061000 negative regulation of dendritic spine development GO:0061001 regulation of dendritic spine morphogenesis GO:0061002 negative regulation of dendritic spine morphogenesis GO:0061564 axon development GO:0071625 vocalization behavior GO:0071709 membrane assembly GO:0072553 terminal button organization GO:0090394 negative regulation of excitatory postsynaptic potential GO:0097061 dendritic spine organization GO:0097090 presynaptic membrane organization GO:0097091 synaptic vesicle clustering GO:0097104 postsynaptic membrane assembly GO:0097105 presynaptic membrane assembly GO:0097479 synaptic vesicle localization GO:0098815 modulation of excitatory postsynaptic potential GO:0099054 presynapse assembly GO:0099068 postsynapse assembly GO:0099504 synaptic vesicle cycle GO:0099565 chemical synaptic transmission, postsynaptic GO:0099601 regulation of neurotransmitter receptor activity GO:1900271 regulation of long-term synaptic potentiation GO:1900449 regulation of glutamate receptor signaling pathway GO:1900451 positive regulation of glutamate receptor signaling pathway GO:1990138 neuron projection extension GO:2000171 negative regulation of dendrite development GO:2000273 positive regulation of receptor activity GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity GO:2000331 regulation of terminal button organization GO:2000463 positive regulation of excitatory postsynaptic potential GO:2000807 regulation of synaptic vesicle clustering GO:2000809 positive regulation of synaptic vesicle clustering GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
Molecular Function |
GO:0042043 neurexin family protein binding GO:0050839 cell adhesion molecule binding GO:0052689 carboxylic ester hydrolase activity GO:0097110 scaffold protein binding |
Cellular Component |
GO:0030139 endocytic vesicle GO:0060076 excitatory synapse GO:0098794 postsynapse |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) |
Reactome |
R-HSA-6794361: Interactions of neurexins and neuroligins at synapses R-HSA-112316: Neuronal System R-HSA-6794362: Protein-protein interactions at synapses |
Summary | |
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Symbol | NLGN3 |
Name | neuroligin 3 |
Aliases | HNL3; KIAA1480; ASPGX1; AUTSX1; gliotactin homolog; Neuroligin-3 |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NLGN3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NLGN3 |
Name | neuroligin 3 |
Aliases | HNL3; KIAA1480; ASPGX1; AUTSX1; gliotactin homolog; Neuroligin-3 |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NLGN3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NLGN3 |
Name | neuroligin 3 |
Aliases | HNL3; KIAA1480; ASPGX1; AUTSX1; gliotactin homolog; Neuroligin-3 |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NLGN3 in various data sets.
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Points in the above scatter plot represent the mutation difference of NLGN3 in various data sets.
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Summary | |
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Symbol | NLGN3 |
Name | neuroligin 3 |
Aliases | HNL3; KIAA1480; ASPGX1; AUTSX1; gliotactin homolog; Neuroligin-3 |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NLGN3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NLGN3 |
Name | neuroligin 3 |
Aliases | HNL3; KIAA1480; ASPGX1; AUTSX1; gliotactin homolog; Neuroligin-3 |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NLGN3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NLGN3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NLGN3 |
Name | neuroligin 3 |
Aliases | HNL3; KIAA1480; ASPGX1; AUTSX1; gliotactin homolog; Neuroligin-3 |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NLGN3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NLGN3 |
Name | neuroligin 3 |
Aliases | HNL3; KIAA1480; ASPGX1; AUTSX1; gliotactin homolog; Neuroligin-3 |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NLGN3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NLGN3 |
Name | neuroligin 3 |
Aliases | HNL3; KIAA1480; ASPGX1; AUTSX1; gliotactin homolog; Neuroligin-3 |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NLGN3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |