Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion intermembrane space Cytoplasm |
Domain |
PF01432 Peptidase family M3 |
Function |
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. |
Biological Process |
GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006094 gluconeogenesis GO:0006109 regulation of carbohydrate metabolic process GO:0006111 regulation of gluconeogenesis GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010830 regulation of myotube differentiation GO:0010906 regulation of glucose metabolic process GO:0014706 striated muscle tissue development GO:0014902 myotube differentiation GO:0016051 carbohydrate biosynthetic process GO:0016202 regulation of striated muscle tissue development GO:0019318 hexose metabolic process GO:0019319 hexose biosynthetic process GO:0035914 skeletal muscle cell differentiation GO:0042692 muscle cell differentiation GO:0043255 regulation of carbohydrate biosynthetic process GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0046364 monosaccharide biosynthetic process GO:0048634 regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0098528 skeletal muscle fiber differentiation GO:1901861 regulation of muscle tissue development GO:1902809 regulation of skeletal muscle fiber differentiation GO:2001014 regulation of skeletal muscle cell differentiation |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0008237 metallopeptidase activity GO:0033218 amide binding GO:0042277 peptide binding |
Cellular Component |
GO:0005758 mitochondrial intermembrane space GO:0031970 organelle envelope lumen |
KEGG |
hsa04614 Renin-angiotensin system |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-500792: GPCR ligand binding R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NLN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of NLN in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NLN in various data sets.
|
Points in the above scatter plot represent the mutation difference of NLN in various data sets.
|
Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NLN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NLN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NLN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NLN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NLN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NLN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NLN |
Name | neurolysin (metallopeptidase M3 family) |
Aliases | KIAA1226; AGTBP; angiotensin binding protein; EP24.16; angiotensin-binding protein; endopeptidase 24.16; mic ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NLN collected from DrugBank database. |
There is no record. |