Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF05186 Dpy-30 motif PF00334 Nucleoside diphosphate kinase |
Function |
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). |
Biological Process |
GO:0003341 cilium movement GO:0003351 epithelial cilium movement GO:0006164 purine nucleotide biosynthetic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006183 GTP biosynthetic process GO:0006213 pyrimidine nucleoside metabolic process GO:0006220 pyrimidine nucleotide metabolic process GO:0006221 pyrimidine nucleotide biosynthetic process GO:0006228 UTP biosynthetic process GO:0006241 CTP biosynthetic process GO:0006979 response to oxidative stress GO:0007018 microtubule-based movement GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009142 nucleoside triphosphate biosynthetic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009145 purine nucleoside triphosphate biosynthetic process GO:0009147 pyrimidine nucleoside triphosphate metabolic process GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009163 nucleoside biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009201 ribonucleoside triphosphate biosynthetic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009206 purine ribonucleoside triphosphate biosynthetic process GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process GO:0009218 pyrimidine ribonucleotide metabolic process GO:0009220 pyrimidine ribonucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0010927 cellular component assembly involved in morphogenesis GO:0021591 ventricular system development GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030031 cell projection assembly GO:0034599 cellular response to oxidative stress GO:0036473 cell death in response to oxidative stress GO:0042278 purine nucleoside metabolic process GO:0042384 cilium assembly GO:0042451 purine nucleoside biosynthetic process GO:0042455 ribonucleoside biosynthetic process GO:0044782 cilium organization GO:0046036 CTP metabolic process GO:0046039 GTP metabolic process GO:0046051 UTP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046129 purine ribonucleoside biosynthetic process GO:0046131 pyrimidine ribonucleoside metabolic process GO:0046132 pyrimidine ribonucleoside biosynthetic process GO:0046134 pyrimidine nucleoside biosynthetic process GO:0046390 ribose phosphate biosynthetic process GO:0046939 nucleotide phosphorylation GO:0048232 male gamete generation GO:0048515 spermatid differentiation GO:0060271 cilium morphogenesis GO:0072522 purine-containing compound biosynthetic process GO:0072527 pyrimidine-containing compound metabolic process GO:0072528 pyrimidine-containing compound biosynthetic process GO:0097193 intrinsic apoptotic signaling pathway GO:1900407 regulation of cellular response to oxidative stress GO:1900408 negative regulation of cellular response to oxidative stress GO:1901068 guanosine-containing compound metabolic process GO:1901070 guanosine-containing compound biosynthetic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901657 glycosyl compound metabolic process GO:1901659 glycosyl compound biosynthetic process GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1902882 regulation of response to oxidative stress GO:1902883 negative regulation of response to oxidative stress GO:1903201 regulation of oxidative stress-induced cell death GO:1903202 negative regulation of oxidative stress-induced cell death GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0004550 nucleoside diphosphate kinase activity GO:0016776 phosphotransferase activity, phosphate group as acceptor GO:0019205 nucleobase-containing compound kinase activity |
Cellular Component |
GO:0005929 cilium GO:0031514 motile cilium GO:0036126 sperm flagellum GO:0097223 sperm part |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NME5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of NME5 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NME5 in various data sets.
|
Points in the above scatter plot represent the mutation difference of NME5 in various data sets.
|
Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NME5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NME5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NME5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NME5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NME5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NME5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NME5 |
Name | NME/NM23 family member 5 |
Aliases | nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NME5 collected from DrugBank database. |
There is no record. |