Summary | |
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Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Membrane Peripheral membrane protein |
Domain |
PF01233 Myristoyl-CoA PF02799 Myristoyl-CoA |
Function |
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. |
Biological Process |
GO:0006497 protein lipidation GO:0006498 N-terminal protein lipidation GO:0006499 N-terminal protein myristoylation GO:0007602 phototransduction GO:0007603 phototransduction, visible light GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009583 detection of light stimulus GO:0009584 detection of visible light GO:0016056 rhodopsin mediated signaling pathway GO:0018008 N-terminal peptidyl-glycine N-myristoylation GO:0018201 peptidyl-glycine modification GO:0018377 protein myristoylation GO:0019058 viral life cycle GO:0022400 regulation of rhodopsin mediated signaling pathway GO:0031365 N-terminal protein amino acid modification GO:0042157 lipoprotein metabolic process GO:0042158 lipoprotein biosynthetic process GO:0043543 protein acylation GO:0044766 multi-organism transport GO:0046794 transport of virus GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071482 cellular response to light stimulus GO:0075733 intracellular transport of virus GO:1902579 multi-organism localization GO:1902581 multi-organism cellular localization GO:1902583 multi-organism intracellular transport |
Molecular Function |
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0019107 myristoyltransferase activity |
Cellular Component |
GO:0019898 extrinsic component of membrane |
KEGG | - |
Reactome |
R-HSA-175474: Assembly Of The HIV Virion R-HSA-1643685: Disease R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-2514859: Inactivation, recovery and regulation of the phototransduction cascade R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-174490: Membrane binding and targetting of GAG proteins R-HSA-162582: Signal Transduction R-HSA-174495: Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-2514856: The phototransduction cascade R-HSA-2187338: Visual phototransduction |
Summary | |
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Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NMT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NMT2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NMT2 in various data sets.
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There is no record. |
Summary | |
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Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NMT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NMT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NMT2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NMT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NMT2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NMT2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NMT2 |
Name | N-myristoyltransferase 2 |
Aliases | NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ...... |
Chromosomal Location | 10p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NMT2 collected from DrugBank database. |
Details on drugs targeting NMT2.
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