Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). |
Domain |
PF00667 FAD binding domain PF00258 Flavodoxin PF00175 Oxidoreductase NAD-binding domain PF02898 Nitric oxide synthase PF00595 PDZ domain (Also known as DHR or GLGF) |
Function |
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. |
Biological Process |
GO:0000768 syncytium formation by plasma membrane fusion GO:0001504 neurotransmitter uptake GO:0001505 regulation of neurotransmitter levels GO:0001666 response to hypoxia GO:0002026 regulation of the force of heart contraction GO:0002028 regulation of sodium ion transport GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0003018 vascular process in circulatory system GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006182 cGMP biosynthetic process GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006520 cellular amino acid metabolic process GO:0006525 arginine metabolic process GO:0006527 arginine catabolic process GO:0006809 nitric oxide biosynthetic process GO:0006813 potassium ion transport GO:0006814 sodium ion transport GO:0006816 calcium ion transport GO:0006836 neurotransmitter transport GO:0006837 serotonin transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006941 striated muscle contraction GO:0006942 regulation of striated muscle contraction GO:0006949 syncytium formation GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007263 nitric oxide mediated signal transduction GO:0007520 myoblast fusion GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008217 regulation of blood pressure GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0009063 cellular amino acid catabolic process GO:0009064 glutamine family amino acid metabolic process GO:0009065 glutamine family amino acid catabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0010469 regulation of receptor activity GO:0010522 regulation of calcium ion transport into cytosol GO:0010523 negative regulation of calcium ion transport into cytosol GO:0010765 positive regulation of sodium ion transport GO:0010959 regulation of metal ion transport GO:0014902 myotube differentiation GO:0015672 monovalent inorganic cation transport GO:0015844 monoamine transport GO:0015850 organic hydroxy compound transport GO:0016054 organic acid catabolic process GO:0016570 histone modification GO:0016573 histone acetylation GO:0017014 protein nitrosylation GO:0017144 drug metabolic process GO:0018119 peptidyl-cysteine S-nitrosylation GO:0018198 peptidyl-cysteine modification GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0022898 regulation of transmembrane transporter activity GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030823 regulation of cGMP metabolic process GO:0030825 positive regulation of cGMP metabolic process GO:0030826 regulation of cGMP biosynthetic process GO:0030828 positive regulation of cGMP biosynthetic process GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0031282 regulation of guanylate cyclase activity GO:0031284 positive regulation of guanylate cyclase activity GO:0032409 regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0033555 multicellular organismal response to stress GO:0034762 regulation of transmembrane transport GO:0034764 positive regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034767 positive regulation of ion transmembrane transport GO:0035065 regulation of histone acetylation GO:0035066 positive regulation of histone acetylation GO:0035150 regulation of tube size GO:0035637 multicellular organismal signaling GO:0035725 sodium ion transmembrane transport GO:0036293 response to decreased oxygen levels GO:0042133 neurotransmitter metabolic process GO:0042136 neurotransmitter biosynthetic process GO:0042311 vasodilation GO:0042312 regulation of vasodilation GO:0042493 response to drug GO:0042692 muscle cell differentiation GO:0042737 drug catabolic process GO:0042738 exogenous drug catabolic process GO:0043266 regulation of potassium ion transport GO:0043267 negative regulation of potassium ion transport GO:0043270 positive regulation of ion transport GO:0043271 negative regulation of ion transport GO:0043543 protein acylation GO:0044057 regulation of system process GO:0044282 small molecule catabolic process GO:0045454 cell redox homeostasis GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway GO:0045776 negative regulation of blood pressure GO:0045909 positive regulation of vasodilation GO:0045981 positive regulation of nucleotide metabolic process GO:0046068 cGMP metabolic process GO:0046209 nitric oxide metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0050848 regulation of calcium-mediated signaling GO:0050880 regulation of blood vessel size GO:0051051 negative regulation of transport GO:0051146 striated muscle cell differentiation GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051279 regulation of release of sequestered calcium ion into cytosol GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051339 regulation of lyase activity GO:0051346 negative regulation of hydrolase activity GO:0051349 positive regulation of lyase activity GO:0051480 regulation of cytosolic calcium ion concentration GO:0051580 regulation of neurotransmitter uptake GO:0051581 negative regulation of neurotransmitter uptake GO:0051588 regulation of neurotransmitter transport GO:0051589 negative regulation of neurotransmitter transport GO:0051610 serotonin uptake GO:0051611 regulation of serotonin uptake GO:0051612 negative regulation of serotonin uptake GO:0051924 regulation of calcium ion transport GO:0051926 negative regulation of calcium ion transport GO:0052652 cyclic purine nucleotide metabolic process GO:0055074 calcium ion homeostasis GO:0055117 regulation of cardiac muscle contraction GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0061337 cardiac conduction GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel GO:0070482 response to oxygen levels GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0071875 adrenergic receptor signaling pathway GO:0071877 regulation of adrenergic receptor signaling pathway GO:0071878 negative regulation of adrenergic receptor signaling pathway GO:0071879 positive regulation of adrenergic receptor signaling pathway GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072522 purine-containing compound biosynthetic process GO:0072593 reactive oxygen species metabolic process GO:0086023 adrenergic receptor signaling pathway involved in heart process GO:0086103 G-protein coupled receptor signaling pathway involved in heart process GO:0090066 regulation of anatomical structure size GO:0090257 regulation of muscle system process GO:0090279 regulation of calcium ion import GO:0097553 calcium ion transmembrane import into cytosol GO:0098657 import into cell GO:0098735 positive regulation of the force of heart contraction GO:0098810 neurotransmitter reuptake GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901019 regulation of calcium ion transmembrane transporter activity GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process GO:1901205 negative regulation of adrenergic receptor signaling pathway involved in heart process GO:1901206 positive regulation of adrenergic receptor signaling pathway involved in heart process GO:1901293 nucleoside phosphate biosynthetic process GO:1901565 organonitrogen compound catabolic process GO:1901605 alpha-amino acid metabolic process GO:1901606 alpha-amino acid catabolic process GO:1901983 regulation of protein acetylation GO:1901985 positive regulation of protein acetylation GO:1902275 regulation of chromatin organization GO:1902305 regulation of sodium ion transmembrane transport GO:1902307 positive regulation of sodium ion transmembrane transport GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902656 calcium ion import into cytosol GO:1903169 regulation of calcium ion transmembrane transport GO:1903409 reactive oxygen species biosynthetic process GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1903779 regulation of cardiac conduction GO:1904062 regulation of cation transmembrane transport GO:1904064 positive regulation of cation transmembrane transport GO:1905269 positive regulation of chromatin organization GO:2000021 regulation of ion homeostasis GO:2000756 regulation of peptidyl-lysine acetylation GO:2000758 positive regulation of peptidyl-lysine acetylation GO:2001057 reactive nitrogen species metabolic process GO:2001257 regulation of cation channel activity |
Molecular Function |
GO:0004497 monooxygenase activity GO:0004517 nitric-oxide synthase activity GO:0005506 iron ion binding GO:0005516 calmodulin binding GO:0010181 FMN binding GO:0016247 channel regulator activity GO:0016597 amino acid binding GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0017080 sodium channel regulator activity GO:0020037 heme binding GO:0031406 carboxylic acid binding GO:0034617 tetrahydrobiopterin binding GO:0034618 arginine binding GO:0043168 anion binding GO:0044325 ion channel binding GO:0046870 cadmium ion binding GO:0046906 tetrapyrrole binding GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050661 NADP binding GO:0050662 coenzyme binding GO:0097110 scaffold protein binding |
Cellular Component |
GO:0001917 photoreceptor inner segment GO:0005891 voltage-gated calcium channel complex GO:0005901 caveola GO:0016528 sarcoplasm GO:0016529 sarcoplasmic reticulum GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0030315 T-tubule GO:0030425 dendrite GO:0031674 I band GO:0033017 sarcoplasmic reticulum membrane GO:0034702 ion channel complex GO:0034703 cation channel complex GO:0034704 calcium channel complex GO:0042383 sarcolemma GO:0043197 dendritic spine GO:0043292 contractile fiber GO:0044309 neuron spine GO:0044449 contractile fiber part GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0098589 membrane region GO:0098794 postsynapse GO:0098857 membrane microdomain GO:1902495 transmembrane transporter complex GO:1990351 transporter complex GO:1990425 ryanodine receptor complex |
KEGG |
hsa04020 Calcium signaling pathway hsa04145 Phagosome hsa04713 Circadian entrainment hsa04730 Long-term depression hsa04970 Salivary secretion hsa00330 Arginine and proline metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-5576891: Cardiac conduction R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-5578775: Ion homeostasis R-HSA-397014: Muscle contraction R-HSA-392154: Nitric oxide stimulates guanylate cyclase R-HSA-418346: Platelet homeostasis R-HSA-1222556: ROS, RNS production in phagocytes |
Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NOS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NOS1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NOS1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NOS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of NOS1 in various data sets.
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Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NOS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NOS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NOS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NOS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NOS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NOS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NOS1 |
Name | nitric oxide synthase 1 (neuronal) |
Aliases | nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ...... |
Chromosomal Location | 12q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NOS1 collected from DrugBank database. |
Details on drugs targeting NOS1.
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