Browse NOS1

Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
Domain PF00667 FAD binding domain
PF00258 Flavodoxin
PF00175 Oxidoreductase NAD-binding domain
PF02898 Nitric oxide synthase
PF00595 PDZ domain (Also known as DHR or GLGF)
Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

> Gene Ontology
 
Biological Process GO:0000768 syncytium formation by plasma membrane fusion
GO:0001504 neurotransmitter uptake
GO:0001505 regulation of neurotransmitter levels
GO:0001666 response to hypoxia
GO:0002026 regulation of the force of heart contraction
GO:0002028 regulation of sodium ion transport
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003018 vascular process in circulatory system
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006182 cGMP biosynthetic process
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006520 cellular amino acid metabolic process
GO:0006525 arginine metabolic process
GO:0006527 arginine catabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0006836 neurotransmitter transport
GO:0006837 serotonin transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006941 striated muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0006949 syncytium formation
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007263 nitric oxide mediated signal transduction
GO:0007520 myoblast fusion
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008217 regulation of blood pressure
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009063 cellular amino acid catabolic process
GO:0009064 glutamine family amino acid metabolic process
GO:0009065 glutamine family amino acid catabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0009266 response to temperature stimulus
GO:0009408 response to heat
GO:0010469 regulation of receptor activity
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0010765 positive regulation of sodium ion transport
GO:0010959 regulation of metal ion transport
GO:0014902 myotube differentiation
GO:0015672 monovalent inorganic cation transport
GO:0015844 monoamine transport
GO:0015850 organic hydroxy compound transport
GO:0016054 organic acid catabolic process
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0017014 protein nitrosylation
GO:0017144 drug metabolic process
GO:0018119 peptidyl-cysteine S-nitrosylation
GO:0018198 peptidyl-cysteine modification
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0022898 regulation of transmembrane transporter activity
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030810 positive regulation of nucleotide biosynthetic process
GO:0030823 regulation of cGMP metabolic process
GO:0030825 positive regulation of cGMP metabolic process
GO:0030826 regulation of cGMP biosynthetic process
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031279 regulation of cyclase activity
GO:0031281 positive regulation of cyclase activity
GO:0031282 regulation of guanylate cyclase activity
GO:0031284 positive regulation of guanylate cyclase activity
GO:0032409 regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0033555 multicellular organismal response to stress
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0035065 regulation of histone acetylation
GO:0035066 positive regulation of histone acetylation
GO:0035150 regulation of tube size
GO:0035637 multicellular organismal signaling
GO:0035725 sodium ion transmembrane transport
GO:0036293 response to decreased oxygen levels
GO:0042133 neurotransmitter metabolic process
GO:0042136 neurotransmitter biosynthetic process
GO:0042311 vasodilation
GO:0042312 regulation of vasodilation
GO:0042493 response to drug
GO:0042692 muscle cell differentiation
GO:0042737 drug catabolic process
GO:0042738 exogenous drug catabolic process
GO:0043266 regulation of potassium ion transport
GO:0043267 negative regulation of potassium ion transport
GO:0043270 positive regulation of ion transport
GO:0043271 negative regulation of ion transport
GO:0043543 protein acylation
GO:0044057 regulation of system process
GO:0044282 small molecule catabolic process
GO:0045454 cell redox homeostasis
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045776 negative regulation of blood pressure
GO:0045909 positive regulation of vasodilation
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046068 cGMP metabolic process
GO:0046209 nitric oxide metabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046395 carboxylic acid catabolic process
GO:0050848 regulation of calcium-mediated signaling
GO:0050880 regulation of blood vessel size
GO:0051051 negative regulation of transport
GO:0051146 striated muscle cell differentiation
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051339 regulation of lyase activity
GO:0051346 negative regulation of hydrolase activity
GO:0051349 positive regulation of lyase activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051580 regulation of neurotransmitter uptake
GO:0051581 negative regulation of neurotransmitter uptake
GO:0051588 regulation of neurotransmitter transport
GO:0051589 negative regulation of neurotransmitter transport
GO:0051610 serotonin uptake
GO:0051611 regulation of serotonin uptake
GO:0051612 negative regulation of serotonin uptake
GO:0051924 regulation of calcium ion transport
GO:0051926 negative regulation of calcium ion transport
GO:0052652 cyclic purine nucleotide metabolic process
GO:0055074 calcium ion homeostasis
GO:0055117 regulation of cardiac muscle contraction
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0061337 cardiac conduction
GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0070482 response to oxygen levels
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0071875 adrenergic receptor signaling pathway
GO:0071877 regulation of adrenergic receptor signaling pathway
GO:0071878 negative regulation of adrenergic receptor signaling pathway
GO:0071879 positive regulation of adrenergic receptor signaling pathway
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072522 purine-containing compound biosynthetic process
GO:0072593 reactive oxygen species metabolic process
GO:0086023 adrenergic receptor signaling pathway involved in heart process
GO:0086103 G-protein coupled receptor signaling pathway involved in heart process
GO:0090066 regulation of anatomical structure size
GO:0090257 regulation of muscle system process
GO:0090279 regulation of calcium ion import
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098657 import into cell
GO:0098735 positive regulation of the force of heart contraction
GO:0098810 neurotransmitter reuptake
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900373 positive regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901019 regulation of calcium ion transmembrane transporter activity
GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process
GO:1901205 negative regulation of adrenergic receptor signaling pathway involved in heart process
GO:1901206 positive regulation of adrenergic receptor signaling pathway involved in heart process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901565 organonitrogen compound catabolic process
GO:1901605 alpha-amino acid metabolic process
GO:1901606 alpha-amino acid catabolic process
GO:1901983 regulation of protein acetylation
GO:1901985 positive regulation of protein acetylation
GO:1902275 regulation of chromatin organization
GO:1902305 regulation of sodium ion transmembrane transport
GO:1902307 positive regulation of sodium ion transmembrane transport
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1902656 calcium ion import into cytosol
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903409 reactive oxygen species biosynthetic process
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:1903779 regulation of cardiac conduction
GO:1904062 regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1905269 positive regulation of chromatin organization
GO:2000021 regulation of ion homeostasis
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000758 positive regulation of peptidyl-lysine acetylation
GO:2001057 reactive nitrogen species metabolic process
GO:2001257 regulation of cation channel activity
Molecular Function GO:0004497 monooxygenase activity
GO:0004517 nitric-oxide synthase activity
GO:0005506 iron ion binding
GO:0005516 calmodulin binding
GO:0010181 FMN binding
GO:0016247 channel regulator activity
GO:0016597 amino acid binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0017080 sodium channel regulator activity
GO:0020037 heme binding
GO:0031406 carboxylic acid binding
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0043168 anion binding
GO:0044325 ion channel binding
GO:0046870 cadmium ion binding
GO:0046906 tetrapyrrole binding
GO:0048037 cofactor binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0050662 coenzyme binding
GO:0097110 scaffold protein binding
Cellular Component GO:0001917 photoreceptor inner segment
GO:0005891 voltage-gated calcium channel complex
GO:0005901 caveola
GO:0016528 sarcoplasm
GO:0016529 sarcoplasmic reticulum
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0030425 dendrite
GO:0031674 I band
GO:0033017 sarcoplasmic reticulum membrane
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034704 calcium channel complex
GO:0042383 sarcolemma
GO:0043197 dendritic spine
GO:0043292 contractile fiber
GO:0044309 neuron spine
GO:0044449 contractile fiber part
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0098589 membrane region
GO:0098794 postsynapse
GO:0098857 membrane microdomain
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
GO:1990425 ryanodine receptor complex
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04145 Phagosome
hsa04713 Circadian entrainment
hsa04730 Long-term depression
hsa04970 Salivary secretion
hsa00330 Arginine and proline metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-5576891: Cardiac conduction
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-5578775: Ion homeostasis
R-HSA-397014: Muscle contraction
R-HSA-392154: Nitric oxide stimulates guanylate cyclase
R-HSA-418346: Platelet homeostasis
R-HSA-1222556: ROS, RNS production in phagocytes
Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NOS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between NOS1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
24691438MelanomaInhibit immunity (T cell function)Here, we demonstrated in a coculture system that melanoma cells differentially impairs the IFN-α response in PBMCs and that the inhibitory potential of a particular melanoma cell correlates with NOS1 expression. Evaluation of NOS1 levels in melanomas and IFN responsiveness of purified PBMCs from patients indicated a negative correlation between NOS1 expression in melanomas and the responsiveness of PBMCs to IFN-α.
Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NOS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NOS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6690.159
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6090.461
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7090.315
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2670.584
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.40.819
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0940.964
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.5620.44
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.60.685
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.610.691
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0410.918
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0820.893
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.430.14
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NOS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141721.45.915.50.304
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414257.117.90.405
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277325.99.616.30.0515
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275925.911.9140.122
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211723.85.917.90.197
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.516.720.80.58
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.23.79.50.388
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NOS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NOS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NOS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NOS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NOS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NOS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNOS1
Namenitric oxide synthase 1 (neuronal)
Aliases nNOS; IHPS1; N-NOS; NC-NOS; bNOS; NOS type I; neuronal NOS; peptidyl-cysteine S-nitrosylase NOS1; Nitric oxi ......
Chromosomal Location12q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NOS1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting NOS1.
ID Name Drug Type Targets #Targets
DB00155L-CitrullineSmall MoleculeASS1, DDAH1, DDAH2, NOS1, NOS2, NOS3, OTC, PADI1, PADI2, PADI3, PA ......12
DB01221KetamineSmall MoleculeBCHE, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, GRIN3A, HTR1A, HTR1 ......23
DB01821L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric AmideSmall MoleculeNOS1, NOS32
DB01942Formic AcidSmall MoleculeACYP2, CA2, CASK, CTBP1, CYTH2, FGF1, GGACT, GPHN, HMOX1, NOS1, PV ......12
DB019973-Bromo-7-NitroindazoleSmall MoleculeNOS1, NOS2, NOS33
DB02027N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-NitroguanidineSmall MoleculeNOS1, NOS32
DB02044N-(3-(Aminomethyl)Benzyl)AcetamidineSmall MoleculeNOS1, NOS2, NOS33
DB02077L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline AmideSmall MoleculeNOS1, NOS32
DB02143N-Isopropyl-N'-HydroxyguanidineSmall MoleculeNOS11
DB02644N-Omega-Propyl-L-ArginineSmall MoleculeNOS1, NOS22
DB02727N-Butyl-N'-HydroxyguanidineSmall MoleculeNOS11
DB02991S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]IsothioureaSmall MoleculeNOS11
DB03144N-Omega-Hydroxy-L-ArginineSmall MoleculeARG1, NOS1, NOS2, NOS34
DB03147Flavin adenine dinucleotideSmall MoleculeACAD8, ACADM, ACADS, ACOX1, AIFM1, CYB5R1, CYB5R3, DAO, DLD, DPYD, ......26
DB03247Flavin mononucleotideSmall MoleculeBLVRB, DHODH, DPYD, HAO1, HAO2, NOS1, PNPO, POR, PPCDC, RFK, RPS6K ......12
DB03449N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-ThiophecarboxamidineSmall MoleculeNOS1, NOS22
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeADH1B, AKR1A1, AKR1B1, AKR1B10, AKR1C1, AKR1C2, AKR1C3, BLVRB, CRY ......28
DB03707S-Ethyl-N-Phenyl-IsothioureaSmall MoleculeNOS1, NOS32
DB03710N5-(1-Imino-3-Butenyl)-L-OrnithineSmall MoleculeNOS11
DB038925-N-Allyl-ArginineSmall MoleculeNOS11
DB04223NitroarginineSmall MoleculeNOS1, NOS32
DB06096NXN-188Small MoleculeHTR1B, HTR1D, NOS13
DB08018N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINESmall MoleculeNOS1, NOS32
DB08019N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamineSmall MoleculeNOS1, NOS32
DB09241Methylene blueSmall MoleculeGUCY1A2, NOS12