Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00667 FAD binding domain PF00258 Flavodoxin PF00175 Oxidoreductase NAD-binding domain PF02898 Nitric oxide synthase |
Function |
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109). |
Biological Process |
GO:0001666 response to hypoxia GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO:0002227 innate immune response in mucosa GO:0002237 response to molecule of bacterial origin GO:0002251 organ or tissue specific immune response GO:0002385 mucosal immune response GO:0002532 production of molecular mediator involved in inflammatory response GO:0002534 cytokine production involved in inflammatory response GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006091 generation of precursor metabolites and energy GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006182 cGMP biosynthetic process GO:0006520 cellular amino acid metabolic process GO:0006525 arginine metabolic process GO:0006527 arginine catabolic process GO:0006801 superoxide metabolic process GO:0006809 nitric oxide biosynthetic process GO:0006820 anion transport GO:0006869 lipid transport GO:0007263 nitric oxide mediated signal transduction GO:0007623 circadian rhythm GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0009063 cellular amino acid catabolic process GO:0009064 glutamine family amino acid metabolic process GO:0009065 glutamine family amino acid catabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009306 protein secretion GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015732 prostaglandin transport GO:0015833 peptide transport GO:0015908 fatty acid transport GO:0015980 energy derivation by oxidation of organic compounds GO:0016054 organic acid catabolic process GO:0017014 protein nitrosylation GO:0018119 peptidyl-cysteine S-nitrosylation GO:0018198 peptidyl-cysteine modification GO:0019932 second-messenger-mediated signaling GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030823 regulation of cGMP metabolic process GO:0030825 positive regulation of cGMP metabolic process GO:0030826 regulation of cGMP biosynthetic process GO:0030828 positive regulation of cGMP biosynthetic process GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0031282 regulation of guanylate cyclase activity GO:0031284 positive regulation of guanylate cyclase activity GO:0031341 regulation of cell killing GO:0031343 positive regulation of cell killing GO:0031640 killing of cells of other organism GO:0032309 icosanoid secretion GO:0032310 prostaglandin secretion GO:0032496 response to lipopolysaccharide GO:0032635 interleukin-6 production GO:0032637 interleukin-8 production GO:0034341 response to interferon-gamma GO:0035150 regulation of tube size GO:0035690 cellular response to drug GO:0035821 modification of morphology or physiology of other organism GO:0036293 response to decreased oxygen levels GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0042311 vasodilation GO:0042312 regulation of vasodilation GO:0042493 response to drug GO:0042742 defense response to bacterium GO:0042886 amide transport GO:0043457 regulation of cellular respiration GO:0043467 regulation of generation of precursor metabolites and energy GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0044057 regulation of system process GO:0044282 small molecule catabolic process GO:0044364 disruption of cells of other organism GO:0045333 cellular respiration GO:0045454 cell redox homeostasis GO:0045776 negative regulation of blood pressure GO:0045909 positive regulation of vasodilation GO:0045981 positive regulation of nucleotide metabolic process GO:0046068 cGMP metabolic process GO:0046209 nitric oxide metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046942 carboxylic acid transport GO:0048511 rhythmic process GO:0050663 cytokine secretion GO:0050708 regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050796 regulation of insulin secretion GO:0050829 defense response to Gram-negative bacterium GO:0050880 regulation of blood vessel size GO:0051339 regulation of lyase activity GO:0051349 positive regulation of lyase activity GO:0051709 regulation of killing of cells of other organism GO:0051712 positive regulation of killing of cells of other organism GO:0052652 cyclic purine nucleotide metabolic process GO:0070482 response to oxygen levels GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071346 cellular response to interferon-gamma GO:0071396 cellular response to lipid GO:0071715 icosanoid transport GO:0072522 purine-containing compound biosynthetic process GO:0072593 reactive oxygen species metabolic process GO:0072604 interleukin-6 secretion GO:0072606 interleukin-8 secretion GO:0090066 regulation of anatomical structure size GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0098542 defense response to other organism GO:1900015 regulation of cytokine production involved in inflammatory response GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901565 organonitrogen compound catabolic process GO:1901605 alpha-amino acid metabolic process GO:1901606 alpha-amino acid catabolic process GO:1903409 reactive oxygen species biosynthetic process GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:2001057 reactive nitrogen species metabolic process |
Molecular Function |
GO:0004497 monooxygenase activity GO:0004517 nitric-oxide synthase activity GO:0005516 calmodulin binding GO:0010181 FMN binding GO:0016597 amino acid binding GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0020037 heme binding GO:0031406 carboxylic acid binding GO:0034617 tetrahydrobiopterin binding GO:0034618 arginine binding GO:0043168 anion binding GO:0046906 tetrapyrrole binding GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050661 NADP binding GO:0050662 coenzyme binding |
Cellular Component |
GO:0005777 peroxisome GO:0005938 cell cortex GO:0030863 cortical cytoskeleton GO:0042579 microbody GO:0044448 cell cortex part GO:0099568 cytoplasmic region |
KEGG |
hsa04020 Calcium signaling pathway hsa04066 HIF-1 signaling pathway hsa04146 Peroxisome hsa00330 Arginine and proline metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-392154: Nitric oxide stimulates guanylate cyclase R-HSA-418346: Platelet homeostasis R-HSA-1222556: ROS, RNS production in phagocytes R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NOS2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NOS2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NOS2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NOS2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NOS2 in various data sets.
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Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NOS2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NOS2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NOS2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NOS2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NOS2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NOS2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NOS2 |
Name | nitric oxide synthase 2, inducible |
Aliases | HEP-NOS; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes); NOSA; NOS type II; NOS, type II; hepatocy ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NOS2 collected from DrugBank database. |
Details on drugs targeting NOS2.
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