Browse NOTCH1

Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Notch 1 intracellular domain: Nucleus Note=Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10.
Domain PF12796 Ankyrin repeats (3 copies)
PF11936 Domain of unknown function (DUF3454)
PF00008 EGF-like domain
PF07645 Calcium-binding EGF domain
PF12661 Human growth factor-like EGF
PF06816 NOTCH protein
PF07684 NOTCH protein
PF00066 LNR domain
Function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001655 urogenital system development
GO:0001666 response to hypoxia
GO:0001667 ameboidal-type cell migration
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001756 somitogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0001942 hair follicle development
GO:0001947 heart looping
GO:0002011 morphogenesis of an epithelial sheet
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002052 positive regulation of neuroblast proliferation
GO:0002064 epithelial cell development
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002067 glandular epithelial cell differentiation
GO:0002085 inhibition of neuroepithelial cell differentiation
GO:0002237 response to molecule of bacterial origin
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002328 pro-B cell differentiation
GO:0002437 inflammatory response to antigenic stimulus
GO:0002683 negative regulation of immune system process
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003143 embryonic heart tube morphogenesis
GO:0003156 regulation of animal organ formation
GO:0003157 endocardium development
GO:0003158 endothelium development
GO:0003159 morphogenesis of an endothelium
GO:0003160 endocardium morphogenesis
GO:0003161 cardiac conduction system development
GO:0003162 atrioventricular node development
GO:0003169 coronary vein morphogenesis
GO:0003170 heart valve development
GO:0003171 atrioventricular valve development
GO:0003174 mitral valve development
GO:0003176 aortic valve development
GO:0003177 pulmonary valve development
GO:0003179 heart valve morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003188 heart valve formation
GO:0003190 atrioventricular valve formation
GO:0003192 mitral valve formation
GO:0003197 endocardial cushion development
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003207 cardiac chamber formation
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003211 cardiac ventricle formation
GO:0003213 cardiac right atrium morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003219 cardiac right ventricle formation
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0003230 cardiac atrium development
GO:0003231 cardiac ventricle development
GO:0003241 growth involved in heart morphogenesis
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003264 regulation of cardioblast proliferation
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003272 endocardial cushion formation
GO:0003273 cell migration involved in endocardial cushion formation
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0003344 pericardium morphogenesis
GO:0003348 cardiac endothelial cell differentiation
GO:0006352 DNA-templated transcription, initiation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006887 exocytosis
GO:0006959 humoral immune response
GO:0007162 negative regulation of cell adhesion
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007259 JAK-STAT cascade
GO:0007283 spermatogenesis
GO:0007368 determination of left/right symmetry
GO:0007386 compartment pattern specification
GO:0007389 pattern specification process
GO:0007405 neuroblast proliferation
GO:0007409 axonogenesis
GO:0007423 sensory organ development
GO:0007440 foregut morphogenesis
GO:0007492 endoderm development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0008544 epidermis development
GO:0008593 regulation of Notch signaling pathway
GO:0009306 protein secretion
GO:0009798 axis specification
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0009912 auditory receptor cell fate commitment
GO:0009913 epidermal cell differentiation
GO:0009952 anterior/posterior pattern specification
GO:0010001 glial cell differentiation
GO:0010002 cardioblast differentiation
GO:0010594 regulation of endothelial cell migration
GO:0010596 negative regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010633 negative regulation of epithelial cell migration
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010810 regulation of cell-substrate adhesion
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010830 regulation of myotube differentiation
GO:0010832 negative regulation of myotube differentiation
GO:0014009 glial cell proliferation
GO:0014013 regulation of gliogenesis
GO:0014014 negative regulation of gliogenesis
GO:0014015 positive regulation of gliogenesis
GO:0014031 mesenchymal cell development
GO:0014706 striated muscle tissue development
GO:0014807 regulation of somitogenesis
GO:0014855 striated muscle cell proliferation
GO:0014902 myotube differentiation
GO:0016055 Wnt signaling pathway
GO:0016202 regulation of striated muscle tissue development
GO:0016525 negative regulation of angiogenesis
GO:0017145 stem cell division
GO:0017156 calcium ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0017158 regulation of calcium ion-dependent exocytosis
GO:0019058 viral life cycle
GO:0019079 viral genome replication
GO:0019080 viral gene expression
GO:0019083 viral transcription
GO:0019827 stem cell population maintenance
GO:0021510 spinal cord development
GO:0021515 cell differentiation in spinal cord
GO:0021915 neural tube development
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022612 gland morphogenesis
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030198 extracellular matrix organization
GO:0030216 keratinocyte differentiation
GO:0030278 regulation of ossification
GO:0030279 negative regulation of ossification
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030850 prostate gland development
GO:0030856 regulation of epithelial cell differentiation
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0031069 hair follicle morphogenesis
GO:0031099 regeneration
GO:0031100 animal organ regeneration
GO:0031589 cell-substrate adhesion
GO:0031960 response to corticosteroid
GO:0032102 negative regulation of response to external stimulus
GO:0032354 response to follicle-stimulating hormone
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0032633 interleukin-4 production
GO:0032835 glomerulus development
GO:0033002 muscle cell proliferation
GO:0034698 response to gonadotropin
GO:0035050 embryonic heart tube development
GO:0035051 cardiocyte differentiation
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035265 organ growth
GO:0035282 segmentation
GO:0035315 hair cell differentiation
GO:0035767 endothelial cell chemotaxis
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0035886 vascular smooth muscle cell differentiation
GO:0035904 aorta development
GO:0035909 aorta morphogenesis
GO:0035914 skeletal muscle cell differentiation
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0040013 negative regulation of locomotion
GO:0040017 positive regulation of locomotion
GO:0040034 regulation of development, heterochronic
GO:0042063 gliogenesis
GO:0042246 tissue regeneration
GO:0042303 molting cycle
GO:0042490 mechanoreceptor differentiation
GO:0042491 auditory receptor cell differentiation
GO:0042633 hair cycle
GO:0042692 muscle cell differentiation
GO:0042733 embryonic digit morphogenesis
GO:0043062 extracellular structure organization
GO:0043276 anoikis
GO:0043534 blood vessel endothelial cell migration
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0043583 ear development
GO:0043588 skin development
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0043900 regulation of multi-organism process
GO:0043902 positive regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044033 multi-organism metabolic process
GO:0045055 regulated exocytosis
GO:0045069 regulation of viral genome replication
GO:0045070 positive regulation of viral genome replication
GO:0045165 cell fate commitment
GO:0045445 myoblast differentiation
GO:0045446 endothelial cell differentiation
GO:0045601 regulation of endothelial cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045604 regulation of epidermal cell differentiation
GO:0045605 negative regulation of epidermal cell differentiation
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045607 regulation of auditory receptor cell differentiation
GO:0045608 negative regulation of auditory receptor cell differentiation
GO:0045616 regulation of keratinocyte differentiation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045631 regulation of mechanoreceptor differentiation
GO:0045632 negative regulation of mechanoreceptor differentiation
GO:0045661 regulation of myoblast differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045682 regulation of epidermis development
GO:0045683 negative regulation of epidermis development
GO:0045684 positive regulation of epidermis development
GO:0045685 regulation of glial cell differentiation
GO:0045686 negative regulation of glial cell differentiation
GO:0045687 positive regulation of glial cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045765 regulation of angiogenesis
GO:0045844 positive regulation of striated muscle tissue development
GO:0045920 negative regulation of exocytosis
GO:0045927 positive regulation of growth
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0045995 regulation of embryonic development
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046530 photoreceptor cell differentiation
GO:0046532 regulation of photoreceptor cell differentiation
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0046620 regulation of organ growth
GO:0046622 positive regulation of organ growth
GO:0046782 regulation of viral transcription
GO:0048103 somatic stem cell division
GO:0048232 male gamete generation
GO:0048505 regulation of timing of cell differentiation
GO:0048514 blood vessel morphogenesis
GO:0048524 positive regulation of viral process
GO:0048545 response to steroid hormone
GO:0048546 digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048644 muscle organ morphogenesis
GO:0048663 neuron fate commitment
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048708 astrocyte differentiation
GO:0048709 oligodendrocyte differentiation
GO:0048710 regulation of astrocyte differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0048736 appendage development
GO:0048738 cardiac muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048839 inner ear development
GO:0048844 artery morphogenesis
GO:0048845 venous blood vessel morphogenesis
GO:0048863 stem cell differentiation
GO:0050434 positive regulation of viral transcription
GO:0050663 cytokine secretion
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050792 regulation of viral process
GO:0050920 regulation of chemotaxis
GO:0050922 negative regulation of chemotaxis
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051145 smooth muscle cell differentiation
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0055001 muscle cell development
GO:0055006 cardiac cell development
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055017 cardiac muscle tissue growth
GO:0055021 regulation of cardiac muscle tissue growth
GO:0055023 positive regulation of cardiac muscle tissue growth
GO:0055024 regulation of cardiac muscle tissue development
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0055123 digestive system development
GO:0060038 cardiac muscle cell proliferation
GO:0060039 pericardium development
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0060113 inner ear receptor cell differentiation
GO:0060120 inner ear receptor cell fate commitment
GO:0060173 limb development
GO:0060251 regulation of glial cell proliferation
GO:0060253 negative regulation of glial cell proliferation
GO:0060271 cilium morphogenesis
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060326 cell chemotaxis
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060415 muscle tissue morphogenesis
GO:0060419 heart growth
GO:0060420 regulation of heart growth
GO:0060421 positive regulation of heart growth
GO:0060485 mesenchyme development
GO:0060512 prostate gland morphogenesis
GO:0060525 prostate glandular acinus development
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060541 respiratory system development
GO:0060560 developmental growth involved in morphogenesis
GO:0060561 apoptotic process involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060563 neuroepithelial cell differentiation
GO:0060627 regulation of vesicle-mediated transport
GO:0060740 prostate gland epithelium morphogenesis
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060767 epithelial cell proliferation involved in prostate gland development
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060837 blood vessel endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0060842 arterial endothelial cell differentiation
GO:0060843 venous endothelial cell differentiation
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060956 endocardial cell differentiation
GO:0060972 left/right pattern formation
GO:0060973 cell migration involved in heart development
GO:0060976 coronary vasculature development
GO:0060977 coronary vasculature morphogenesis
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0061005 cell differentiation involved in kidney development
GO:0061008 hepaticobiliary system development
GO:0061053 somite development
GO:0061138 morphogenesis of a branching epithelium
GO:0061311 cell surface receptor signaling pathway involved in heart development
GO:0061314 Notch signaling involved in heart development
GO:0061326 renal tubule development
GO:0061351 neural precursor cell proliferation
GO:0061371 determination of heart left/right asymmetry
GO:0061383 trabecula morphogenesis
GO:0061384 heart trabecula morphogenesis
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061437 renal system vasculature development
GO:0061440 kidney vasculature development
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0061564 axon development
GO:0070482 response to oxygen levels
GO:0070986 left/right axis specification
GO:0071371 cellular response to gonadotropin stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072007 mesangial cell differentiation
GO:0072008 glomerular mesangial cell differentiation
GO:0072009 nephron epithelium development
GO:0072012 glomerulus vasculature development
GO:0072017 distal tubule development
GO:0072044 collecting duct development
GO:0072073 kidney epithelium development
GO:0072080 nephron tubule development
GO:0072089 stem cell proliferation
GO:0072091 regulation of stem cell proliferation
GO:0072109 glomerular mesangium development
GO:0072132 mesenchyme morphogenesis
GO:0072143 mesangial cell development
GO:0072144 glomerular mesangial cell development
GO:0072148 epithelial cell fate commitment
GO:0072602 interleukin-4 secretion
GO:0085029 extracellular matrix assembly
GO:0090049 regulation of cell migration involved in sprouting angiogenesis
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0097084 vascular smooth muscle cell development
GO:0097150 neuronal stem cell population maintenance
GO:0097696 STAT cascade
GO:0098727 maintenance of cell number
GO:0098773 skin epidermis development
GO:0198738 cell-cell signaling by wnt
GO:1901201 regulation of extracellular matrix assembly
GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development
GO:1901342 regulation of vasculature development
GO:1901343 negative regulation of vasculature development
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1901532 regulation of hematopoietic progenitor cell differentiation
GO:1901533 negative regulation of hematopoietic progenitor cell differentiation
GO:1901652 response to peptide
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:1902692 regulation of neuroblast proliferation
GO:1902742 apoptotic process involved in development
GO:1903053 regulation of extracellular matrix organization
GO:1903305 regulation of regulated secretory pathway
GO:1903306 negative regulation of regulated secretory pathway
GO:1903531 negative regulation of secretion by cell
GO:1903670 regulation of sprouting angiogenesis
GO:1903671 negative regulation of sprouting angiogenesis
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1903847 regulation of aorta morphogenesis
GO:1903849 positive regulation of aorta morphogenesis
GO:1903900 regulation of viral life cycle
GO:1903902 positive regulation of viral life cycle
GO:1904018 positive regulation of vasculature development
GO:1904238 pericyte cell differentiation
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
GO:1905314 semi-lunar valve development
GO:2000027 regulation of organ morphogenesis
GO:2000136 regulation of cell proliferation involved in heart morphogenesis
GO:2000146 negative regulation of cell motility
GO:2000147 positive regulation of cell motility
GO:2000177 regulation of neural precursor cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000181 negative regulation of blood vessel morphogenesis
GO:2000209 regulation of anoikis
GO:2000241 regulation of reproductive process
GO:2000648 positive regulation of stem cell proliferation
GO:2000736 regulation of stem cell differentiation
GO:2000737 negative regulation of stem cell differentiation
GO:2000811 negative regulation of anoikis
GO:2000826 regulation of heart morphogenesis
GO:2000973 regulation of pro-B cell differentiation
GO:2000974 negative regulation of pro-B cell differentiation
GO:2000980 regulation of inner ear receptor cell differentiation
GO:2000981 negative regulation of inner ear receptor cell differentiation
GO:2001026 regulation of endothelial cell chemotaxis
GO:2001027 negative regulation of endothelial cell chemotaxis
Molecular Function GO:0001047 core promoter binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0003682 chromatin binding
GO:0004857 enzyme inhibitor activity
GO:0005112 Notch binding
GO:0031490 chromatin DNA binding
GO:0043566 structure-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
Cellular Component GO:0001669 acrosomal vesicle
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
GO:0016324 apical plasma membrane
GO:0030141 secretory granule
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0097223 sperm part
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04320 Dorso-ventral axis formation
hsa04330 Notch signaling pathway
hsa04919 Thyroid hormone signaling pathway
Reactome R-HSA-157212: A third proteolytic cleavage releases NICD
R-HSA-2122948: Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2691232: Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2660826: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1
R-HSA-5083630: Defective LFNG causes SCDO3
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-3906995: Diseases associated with O-glycosylation of proteins
R-HSA-3781865: Diseases of glycosylation
R-HSA-5663202: Diseases of signal transduction
R-HSA-2644605: FBXW7 Mutants and NOTCH1 in Cancer
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-2644607: Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
R-HSA-157052: NICD traffics to nucleus
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-350054: Notch-HLH transcription pathway
R-HSA-1912422: Pre-NOTCH Expression and Processing
R-HSA-1912420: Pre-NOTCH Processing in Golgi
R-HSA-1912399: Pre-NOTCH Processing in the Endoplasmic Reticulum
R-HSA-1912408: Pre-NOTCH Transcription and Translation
R-HSA-156988: Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
R-HSA-186712: Regulation of beta-cell development
R-HSA-210744: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2691230: Signaling by NOTCH1 HD Domain Mutants in Cancer
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-2660825: Signaling by NOTCH1 t(7;9)(NOTCH1
Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NOTCH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between NOTCH1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26523864Ovarian CarcinomaPromote immunity (T cell function)EZH2 activated the Notch pathway by suppressing Notch repressors Numb and Fbxw7 via trimethylation of histone H3 at Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling.
27197152Breast CarcinomaInhibit immunity (T cell function)We suggest that targeting STAT3-NOTCH cross-talk between MDSC and CSC could offer a unique locus to improve cancer treatment, by coordinately targeting a coupled mechanism that enables cancer stemness and immune escape.
29301578B16 Malignant MelanomaInhibit immunity (infiltration)Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1. Notch1 expression in B16 melanoma cells inhibited the infiltration of CD8+ cytotoxic T lymphocytes and NK cells and reduced IFN-γ release in tumor tissue. It could also enhance B16 cell-mediated inhibition of T cell proliferation and activation, and upregulate PD-1 expression on CD4+ and CD8+ T cells. These findings suggested that Notch1 signaling in B16 melanoma cells might inhibit antitumor immunity by upregulation of TGF-β1.
Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NOTCH1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NOTCH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2380.361
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1680.913
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2950.812
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1160.774
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1480.958
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4550.903
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6630.0748
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5650.698
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.8250.598
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8860.366
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.4530.27
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3610.00514
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NOTCH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.35.98.40.576
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1032033.3-13.31
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.23.79.50.388
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111318.2018.20.199
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6133.3033.31
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NOTCH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NOTCH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NOTCH1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NOTCH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NOTCH1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NOTCH1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNOTCH1
Namenotch 1
Aliases Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NOTCH1 collected from DrugBank database.
> Drugs from DrugBank database
 

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