Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Notch 1 intracellular domain: Nucleus Note=Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10. |
Domain |
PF12796 Ankyrin repeats (3 copies) PF11936 Domain of unknown function (DUF3454) PF00008 EGF-like domain PF07645 Calcium-binding EGF domain PF12661 Human growth factor-like EGF PF06816 NOTCH protein PF07684 NOTCH protein PF00066 LNR domain |
Function |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). |
Biological Process |
GO:0001503 ossification GO:0001525 angiogenesis GO:0001570 vasculogenesis GO:0001649 osteoblast differentiation GO:0001655 urogenital system development GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0001701 in utero embryonic development GO:0001708 cell fate specification GO:0001756 somitogenesis GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001837 epithelial to mesenchymal transition GO:0001889 liver development GO:0001942 hair follicle development GO:0001947 heart looping GO:0002011 morphogenesis of an epithelial sheet GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0002052 positive regulation of neuroblast proliferation GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002067 glandular epithelial cell differentiation GO:0002085 inhibition of neuroepithelial cell differentiation GO:0002237 response to molecule of bacterial origin GO:0002244 hematopoietic progenitor cell differentiation GO:0002320 lymphoid progenitor cell differentiation GO:0002328 pro-B cell differentiation GO:0002437 inflammatory response to antigenic stimulus GO:0002683 negative regulation of immune system process GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003143 embryonic heart tube morphogenesis GO:0003156 regulation of animal organ formation GO:0003157 endocardium development GO:0003158 endothelium development GO:0003159 morphogenesis of an endothelium GO:0003160 endocardium morphogenesis GO:0003161 cardiac conduction system development GO:0003162 atrioventricular node development GO:0003169 coronary vein morphogenesis GO:0003170 heart valve development GO:0003171 atrioventricular valve development GO:0003174 mitral valve development GO:0003176 aortic valve development GO:0003177 pulmonary valve development GO:0003179 heart valve morphogenesis GO:0003180 aortic valve morphogenesis GO:0003181 atrioventricular valve morphogenesis GO:0003183 mitral valve morphogenesis GO:0003184 pulmonary valve morphogenesis GO:0003188 heart valve formation GO:0003190 atrioventricular valve formation GO:0003192 mitral valve formation GO:0003197 endocardial cushion development GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003203 endocardial cushion morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003207 cardiac chamber formation GO:0003208 cardiac ventricle morphogenesis GO:0003209 cardiac atrium morphogenesis GO:0003211 cardiac ventricle formation GO:0003213 cardiac right atrium morphogenesis GO:0003214 cardiac left ventricle morphogenesis GO:0003215 cardiac right ventricle morphogenesis GO:0003219 cardiac right ventricle formation GO:0003222 ventricular trabecula myocardium morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003230 cardiac atrium development GO:0003231 cardiac ventricle development GO:0003241 growth involved in heart morphogenesis GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation GO:0003264 regulation of cardioblast proliferation GO:0003266 regulation of secondary heart field cardioblast proliferation GO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation GO:0003272 endocardial cushion formation GO:0003273 cell migration involved in endocardial cushion formation GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0003344 pericardium morphogenesis GO:0003348 cardiac endothelial cell differentiation GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006887 exocytosis GO:0006959 humoral immune response GO:0007162 negative regulation of cell adhesion GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007219 Notch signaling pathway GO:0007221 positive regulation of transcription of Notch receptor target GO:0007259 JAK-STAT cascade GO:0007283 spermatogenesis GO:0007368 determination of left/right symmetry GO:0007386 compartment pattern specification GO:0007389 pattern specification process GO:0007405 neuroblast proliferation GO:0007409 axonogenesis GO:0007423 sensory organ development GO:0007440 foregut morphogenesis GO:0007492 endoderm development GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0008544 epidermis development GO:0008593 regulation of Notch signaling pathway GO:0009306 protein secretion GO:0009798 axis specification GO:0009799 specification of symmetry GO:0009855 determination of bilateral symmetry GO:0009912 auditory receptor cell fate commitment GO:0009913 epidermal cell differentiation GO:0009952 anterior/posterior pattern specification GO:0010001 glial cell differentiation GO:0010002 cardioblast differentiation GO:0010594 regulation of endothelial cell migration GO:0010596 negative regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010810 regulation of cell-substrate adhesion GO:0010812 negative regulation of cell-substrate adhesion GO:0010830 regulation of myotube differentiation GO:0010832 negative regulation of myotube differentiation GO:0014009 glial cell proliferation GO:0014013 regulation of gliogenesis GO:0014014 negative regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0014031 mesenchymal cell development GO:0014706 striated muscle tissue development GO:0014807 regulation of somitogenesis GO:0014855 striated muscle cell proliferation GO:0014902 myotube differentiation GO:0016055 Wnt signaling pathway GO:0016202 regulation of striated muscle tissue development GO:0016525 negative regulation of angiogenesis GO:0017145 stem cell division GO:0017156 calcium ion regulated exocytosis GO:0017157 regulation of exocytosis GO:0017158 regulation of calcium ion-dependent exocytosis GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0019080 viral gene expression GO:0019083 viral transcription GO:0019827 stem cell population maintenance GO:0021510 spinal cord development GO:0021515 cell differentiation in spinal cord GO:0021915 neural tube development GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0022612 gland morphogenesis GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030198 extracellular matrix organization GO:0030216 keratinocyte differentiation GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030323 respiratory tube development GO:0030324 lung development GO:0030326 embryonic limb morphogenesis GO:0030335 positive regulation of cell migration GO:0030336 negative regulation of cell migration GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030513 positive regulation of BMP signaling pathway GO:0030514 negative regulation of BMP signaling pathway GO:0030850 prostate gland development GO:0030856 regulation of epithelial cell differentiation GO:0030857 negative regulation of epithelial cell differentiation GO:0030858 positive regulation of epithelial cell differentiation GO:0030900 forebrain development GO:0031069 hair follicle morphogenesis GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031589 cell-substrate adhesion GO:0031960 response to corticosteroid GO:0032102 negative regulation of response to external stimulus GO:0032354 response to follicle-stimulating hormone GO:0032495 response to muramyl dipeptide GO:0032496 response to lipopolysaccharide GO:0032633 interleukin-4 production GO:0032835 glomerulus development GO:0033002 muscle cell proliferation GO:0034698 response to gonadotropin GO:0035050 embryonic heart tube development GO:0035051 cardiocyte differentiation GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035116 embryonic hindlimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035265 organ growth GO:0035282 segmentation GO:0035315 hair cell differentiation GO:0035767 endothelial cell chemotaxis GO:0035850 epithelial cell differentiation involved in kidney development GO:0035886 vascular smooth muscle cell differentiation GO:0035904 aorta development GO:0035909 aorta morphogenesis GO:0035914 skeletal muscle cell differentiation GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0040034 regulation of development, heterochronic GO:0042063 gliogenesis GO:0042246 tissue regeneration GO:0042303 molting cycle GO:0042490 mechanoreceptor differentiation GO:0042491 auditory receptor cell differentiation GO:0042633 hair cycle GO:0042692 muscle cell differentiation GO:0042733 embryonic digit morphogenesis GO:0043062 extracellular structure organization GO:0043276 anoikis GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043537 negative regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0043583 ear development GO:0043588 skin development GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044033 multi-organism metabolic process GO:0045055 regulated exocytosis GO:0045069 regulation of viral genome replication GO:0045070 positive regulation of viral genome replication GO:0045165 cell fate commitment GO:0045445 myoblast differentiation GO:0045446 endothelial cell differentiation GO:0045601 regulation of endothelial cell differentiation GO:0045603 positive regulation of endothelial cell differentiation GO:0045604 regulation of epidermal cell differentiation GO:0045605 negative regulation of epidermal cell differentiation GO:0045606 positive regulation of epidermal cell differentiation GO:0045607 regulation of auditory receptor cell differentiation GO:0045608 negative regulation of auditory receptor cell differentiation GO:0045616 regulation of keratinocyte differentiation GO:0045618 positive regulation of keratinocyte differentiation GO:0045631 regulation of mechanoreceptor differentiation GO:0045632 negative regulation of mechanoreceptor differentiation GO:0045661 regulation of myoblast differentiation GO:0045662 negative regulation of myoblast differentiation GO:0045665 negative regulation of neuron differentiation GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045682 regulation of epidermis development GO:0045683 negative regulation of epidermis development GO:0045684 positive regulation of epidermis development GO:0045685 regulation of glial cell differentiation GO:0045686 negative regulation of glial cell differentiation GO:0045687 positive regulation of glial cell differentiation GO:0045747 positive regulation of Notch signaling pathway GO:0045765 regulation of angiogenesis GO:0045844 positive regulation of striated muscle tissue development GO:0045920 negative regulation of exocytosis GO:0045927 positive regulation of growth GO:0045955 negative regulation of calcium ion-dependent exocytosis GO:0045995 regulation of embryonic development GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046530 photoreceptor cell differentiation GO:0046532 regulation of photoreceptor cell differentiation GO:0046533 negative regulation of photoreceptor cell differentiation GO:0046620 regulation of organ growth GO:0046622 positive regulation of organ growth GO:0046782 regulation of viral transcription GO:0048103 somatic stem cell division GO:0048232 male gamete generation GO:0048505 regulation of timing of cell differentiation GO:0048514 blood vessel morphogenesis GO:0048524 positive regulation of viral process GO:0048545 response to steroid hormone GO:0048546 digestive tract morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048644 muscle organ morphogenesis GO:0048663 neuron fate commitment GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048708 astrocyte differentiation GO:0048709 oligodendrocyte differentiation GO:0048710 regulation of astrocyte differentiation GO:0048711 positive regulation of astrocyte differentiation GO:0048713 regulation of oligodendrocyte differentiation GO:0048715 negative regulation of oligodendrocyte differentiation GO:0048730 epidermis morphogenesis GO:0048732 gland development GO:0048736 appendage development GO:0048738 cardiac muscle tissue development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0048839 inner ear development GO:0048844 artery morphogenesis GO:0048845 venous blood vessel morphogenesis GO:0048863 stem cell differentiation GO:0050434 positive regulation of viral transcription GO:0050663 cytokine secretion GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050792 regulation of viral process GO:0050920 regulation of chemotaxis GO:0050922 negative regulation of chemotaxis GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051145 smooth muscle cell differentiation GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051154 negative regulation of striated muscle cell differentiation GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0055001 muscle cell development GO:0055006 cardiac cell development GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0055017 cardiac muscle tissue growth GO:0055021 regulation of cardiac muscle tissue growth GO:0055023 positive regulation of cardiac muscle tissue growth GO:0055024 regulation of cardiac muscle tissue development GO:0055025 positive regulation of cardiac muscle tissue development GO:0055123 digestive system development GO:0060038 cardiac muscle cell proliferation GO:0060039 pericardium development GO:0060043 regulation of cardiac muscle cell proliferation GO:0060045 positive regulation of cardiac muscle cell proliferation GO:0060070 canonical Wnt signaling pathway GO:0060113 inner ear receptor cell differentiation GO:0060120 inner ear receptor cell fate commitment GO:0060173 limb development GO:0060251 regulation of glial cell proliferation GO:0060253 negative regulation of glial cell proliferation GO:0060271 cilium morphogenesis GO:0060317 cardiac epithelial to mesenchymal transition GO:0060326 cell chemotaxis GO:0060379 cardiac muscle cell myoblast differentiation GO:0060411 cardiac septum morphogenesis GO:0060412 ventricular septum morphogenesis GO:0060415 muscle tissue morphogenesis GO:0060419 heart growth GO:0060420 regulation of heart growth GO:0060421 positive regulation of heart growth GO:0060485 mesenchyme development GO:0060512 prostate gland morphogenesis GO:0060525 prostate glandular acinus development GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0060541 respiratory system development GO:0060560 developmental growth involved in morphogenesis GO:0060561 apoptotic process involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060563 neuroepithelial cell differentiation GO:0060627 regulation of vesicle-mediated transport GO:0060740 prostate gland epithelium morphogenesis GO:0060742 epithelial cell differentiation involved in prostate gland development GO:0060767 epithelial cell proliferation involved in prostate gland development GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development GO:0060828 regulation of canonical Wnt signaling pathway GO:0060837 blood vessel endothelial cell differentiation GO:0060840 artery development GO:0060841 venous blood vessel development GO:0060842 arterial endothelial cell differentiation GO:0060843 venous endothelial cell differentiation GO:0060947 cardiac vascular smooth muscle cell differentiation GO:0060948 cardiac vascular smooth muscle cell development GO:0060956 endocardial cell differentiation GO:0060972 left/right pattern formation GO:0060973 cell migration involved in heart development GO:0060976 coronary vasculature development GO:0060977 coronary vasculature morphogenesis GO:0060979 vasculogenesis involved in coronary vascular morphogenesis GO:0060982 coronary artery morphogenesis GO:0061005 cell differentiation involved in kidney development GO:0061008 hepaticobiliary system development GO:0061053 somite development GO:0061138 morphogenesis of a branching epithelium GO:0061311 cell surface receptor signaling pathway involved in heart development GO:0061314 Notch signaling involved in heart development GO:0061326 renal tubule development GO:0061351 neural precursor cell proliferation GO:0061371 determination of heart left/right asymmetry GO:0061383 trabecula morphogenesis GO:0061384 heart trabecula morphogenesis GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061437 renal system vasculature development GO:0061440 kidney vasculature development GO:0061448 connective tissue development GO:0061458 reproductive system development GO:0061564 axon development GO:0070482 response to oxygen levels GO:0070986 left/right axis specification GO:0071371 cellular response to gonadotropin stimulus GO:0071372 cellular response to follicle-stimulating hormone stimulus GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0072001 renal system development GO:0072006 nephron development GO:0072007 mesangial cell differentiation GO:0072008 glomerular mesangial cell differentiation GO:0072009 nephron epithelium development GO:0072012 glomerulus vasculature development GO:0072017 distal tubule development GO:0072044 collecting duct development GO:0072073 kidney epithelium development GO:0072080 nephron tubule development GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0072109 glomerular mesangium development GO:0072132 mesenchyme morphogenesis GO:0072143 mesangial cell development GO:0072144 glomerular mesangial cell development GO:0072148 epithelial cell fate commitment GO:0072602 interleukin-4 secretion GO:0085029 extracellular matrix assembly GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:0097084 vascular smooth muscle cell development GO:0097150 neuronal stem cell population maintenance GO:0097696 STAT cascade GO:0098727 maintenance of cell number GO:0098773 skin epidermis development GO:0198738 cell-cell signaling by wnt GO:1901201 regulation of extracellular matrix assembly GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901532 regulation of hematopoietic progenitor cell differentiation GO:1901533 negative regulation of hematopoietic progenitor cell differentiation GO:1901652 response to peptide GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1902263 apoptotic process involved in embryonic digit morphogenesis GO:1902692 regulation of neuroblast proliferation GO:1902742 apoptotic process involved in development GO:1903053 regulation of extracellular matrix organization GO:1903305 regulation of regulated secretory pathway GO:1903306 negative regulation of regulated secretory pathway GO:1903531 negative regulation of secretion by cell GO:1903670 regulation of sprouting angiogenesis GO:1903671 negative regulation of sprouting angiogenesis GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903847 regulation of aorta morphogenesis GO:1903849 positive regulation of aorta morphogenesis GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle GO:1904018 positive regulation of vasculature development GO:1904238 pericyte cell differentiation GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1905314 semi-lunar valve development GO:2000027 regulation of organ morphogenesis GO:2000136 regulation of cell proliferation involved in heart morphogenesis GO:2000146 negative regulation of cell motility GO:2000147 positive regulation of cell motility GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation GO:2000181 negative regulation of blood vessel morphogenesis GO:2000209 regulation of anoikis GO:2000241 regulation of reproductive process GO:2000648 positive regulation of stem cell proliferation GO:2000736 regulation of stem cell differentiation GO:2000737 negative regulation of stem cell differentiation GO:2000811 negative regulation of anoikis GO:2000826 regulation of heart morphogenesis GO:2000973 regulation of pro-B cell differentiation GO:2000974 negative regulation of pro-B cell differentiation GO:2000980 regulation of inner ear receptor cell differentiation GO:2000981 negative regulation of inner ear receptor cell differentiation GO:2001026 regulation of endothelial cell chemotaxis GO:2001027 negative regulation of endothelial cell chemotaxis |
Molecular Function |
GO:0001047 core promoter binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding GO:0004857 enzyme inhibitor activity GO:0005112 Notch binding GO:0031490 chromatin DNA binding GO:0043566 structure-specific DNA binding GO:0046982 protein heterodimerization activity GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding |
Cellular Component |
GO:0001669 acrosomal vesicle GO:0002193 MAML1-RBP-Jkappa- ICN1 complex GO:0016324 apical plasma membrane GO:0030141 secretory granule GO:0043235 receptor complex GO:0045177 apical part of cell GO:0097223 sperm part GO:0099503 secretory vesicle |
KEGG |
hsa04320 Dorso-ventral axis formation hsa04330 Notch signaling pathway hsa04919 Thyroid hormone signaling pathway |
Reactome |
R-HSA-157212: A third proteolytic cleavage releases NICD R-HSA-2122948: Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2691232: Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2660826: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1 R-HSA-5083630: Defective LFNG causes SCDO3 R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-3906995: Diseases associated with O-glycosylation of proteins R-HSA-3781865: Diseases of glycosylation R-HSA-5663202: Diseases of signal transduction R-HSA-2644605: FBXW7 Mutants and NOTCH1 in Cancer R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-2644607: Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-157052: NICD traffics to nucleus R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-350054: Notch-HLH transcription pathway R-HSA-1912422: Pre-NOTCH Expression and Processing R-HSA-1912420: Pre-NOTCH Processing in Golgi R-HSA-1912399: Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912408: Pre-NOTCH Transcription and Translation R-HSA-156988: Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor R-HSA-186712: Regulation of beta-cell development R-HSA-210744: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2691230: Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-2660825: Signaling by NOTCH1 t(7;9)(NOTCH1 |
Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NOTCH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NOTCH1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NOTCH1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NOTCH1 in various data sets.
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Points in the above scatter plot represent the mutation difference of NOTCH1 in various data sets.
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Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NOTCH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NOTCH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NOTCH1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NOTCH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NOTCH1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NOTCH1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NOTCH1 |
Name | notch 1 |
Aliases | Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NOTCH1 collected from DrugBank database. |
There is no record. |