Summary | |
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Symbol | NPHS2 |
Name | nephrosis 2, idiopathic, steroid-resistant (podocin) |
Aliases | SRN1; PDCN; Podocin |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane Peripheral membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum |
Domain |
PF01145 SPFH domain / Band 7 family |
Function |
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. |
Biological Process |
GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001822 kidney development GO:0002064 epithelial cell development GO:0007588 excretion GO:0031532 actin cytoskeleton reorganization GO:0032835 glomerulus development GO:0035850 epithelial cell differentiation involved in kidney development GO:0061005 cell differentiation involved in kidney development GO:0061318 renal filtration cell differentiation GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072010 glomerular epithelium development GO:0072015 glomerular visceral epithelial cell development GO:0072073 kidney epithelium development GO:0072112 glomerular visceral epithelial cell differentiation GO:0072202 cell differentiation involved in metanephros development GO:0072207 metanephric epithelium development GO:0072210 metanephric nephron development GO:0072224 metanephric glomerulus development GO:0072243 metanephric nephron epithelium development GO:0072244 metanephric glomerular epithelium development GO:0072248 metanephric glomerular visceral epithelial cell differentiation GO:0072249 metanephric glomerular visceral epithelial cell development GO:0072310 glomerular epithelial cell development GO:0072311 glomerular epithelial cell differentiation GO:0072312 metanephric glomerular epithelial cell differentiation GO:0072313 metanephric glomerular epithelial cell development |
Molecular Function | - |
Cellular Component |
GO:0009898 cytoplasmic side of plasma membrane GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane GO:0036056 filtration diaphragm GO:0036057 slit diaphragm GO:0045121 membrane raft GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | NPHS2 |
Name | nephrosis 2, idiopathic, steroid-resistant (podocin) |
Aliases | SRN1; PDCN; Podocin |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NPHS2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NPHS2 |
Name | nephrosis 2, idiopathic, steroid-resistant (podocin) |
Aliases | SRN1; PDCN; Podocin |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NPHS2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NPHS2 |
Name | nephrosis 2, idiopathic, steroid-resistant (podocin) |
Aliases | SRN1; PDCN; Podocin |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NPHS2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NPHS2 in various data sets.
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Summary | |
---|---|
Symbol | NPHS2 |
Name | nephrosis 2, idiopathic, steroid-resistant (podocin) |
Aliases | SRN1; PDCN; Podocin |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NPHS2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NPHS2 |
Name | nephrosis 2, idiopathic, steroid-resistant (podocin) |
Aliases | SRN1; PDCN; Podocin |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NPHS2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NPHS2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NPHS2 |
Name | nephrosis 2, idiopathic, steroid-resistant (podocin) |
Aliases | SRN1; PDCN; Podocin |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NPHS2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NPHS2 |
Name | nephrosis 2, idiopathic, steroid-resistant (podocin) |
Aliases | SRN1; PDCN; Podocin |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NPHS2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NPHS2 |
Name | nephrosis 2, idiopathic, steroid-resistant (podocin) |
Aliases | SRN1; PDCN; Podocin |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NPHS2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |