Summary | |
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Symbol | NPNT |
Name | nephronectin |
Aliases | EGFL6L; POEM; preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix Note=Trapped on the cell surface or in the extracellular matrix. |
Domain |
PF07645 Calcium-binding EGF domain PF00629 MAM domain |
Function |
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001823 mesonephros development GO:0003012 muscle system process GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006939 smooth muscle contraction GO:0006940 regulation of smooth muscle contraction GO:0007160 cell-matrix adhesion GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0010692 regulation of alkaline phosphatase activity GO:0010694 positive regulation of alkaline phosphatase activity GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0010921 regulation of phosphatase activity GO:0010922 positive regulation of phosphatase activity GO:0016311 dephosphorylation GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO:0030198 extracellular matrix organization GO:0030278 regulation of ossification GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway GO:0031589 cell-substrate adhesion GO:0033627 cell adhesion mediated by integrin GO:0033631 cell-cell adhesion mediated by integrin GO:0034612 response to tumor necrosis factor GO:0035239 tube morphogenesis GO:0035303 regulation of dephosphorylation GO:0035306 positive regulation of dephosphorylation GO:0042692 muscle cell differentiation GO:0043062 extracellular structure organization GO:0043410 positive regulation of MAPK cascade GO:0044057 regulation of system process GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045778 positive regulation of ossification GO:0045785 positive regulation of cell adhesion GO:0045933 positive regulation of muscle contraction GO:0045987 positive regulation of smooth muscle contraction GO:0048754 branching morphogenesis of an epithelial tube GO:0051145 smooth muscle cell differentiation GO:0060004 reflex GO:0060562 epithelial tube morphogenesis GO:0060675 ureteric bud morphogenesis GO:0060993 kidney morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071356 cellular response to tumor necrosis factor GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072073 kidney epithelium development GO:0072078 nephron tubule morphogenesis GO:0072080 nephron tubule development GO:0072088 nephron epithelium morphogenesis GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090257 regulation of muscle system process GO:0090287 regulation of cellular response to growth factor stimulus GO:0097195 pilomotor reflex GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation |
Molecular Function |
GO:0005178 integrin binding GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0008305 integrin complex GO:0030485 smooth muscle contractile fiber GO:0034678 integrin alpha8-beta1 complex GO:0043235 receptor complex GO:0043292 contractile fiber GO:0044420 extracellular matrix component GO:0044449 contractile fiber part GO:0098636 protein complex involved in cell adhesion GO:0098802 plasma membrane receptor complex |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | NPNT |
Name | nephronectin |
Aliases | EGFL6L; POEM; preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NPNT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NPNT |
Name | nephronectin |
Aliases | EGFL6L; POEM; preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NPNT in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | NPNT |
Name | nephronectin |
Aliases | EGFL6L; POEM; preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NPNT in various data sets.
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Points in the above scatter plot represent the mutation difference of NPNT in various data sets.
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Summary | |
---|---|
Symbol | NPNT |
Name | nephronectin |
Aliases | EGFL6L; POEM; preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NPNT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NPNT |
Name | nephronectin |
Aliases | EGFL6L; POEM; preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NPNT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NPNT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NPNT |
Name | nephronectin |
Aliases | EGFL6L; POEM; preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NPNT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NPNT |
Name | nephronectin |
Aliases | EGFL6L; POEM; preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NPNT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NPNT |
Name | nephronectin |
Aliases | EGFL6L; POEM; preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like |
Chromosomal Location | 4q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NPNT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |