Summary | |
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Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF01094 Receptor family ligand binding region PF00211 Adenylate and Guanylate cyclase catalytic domain PF07714 Protein tyrosine kinase |
Function |
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. |
Biological Process |
GO:0001525 angiogenesis GO:0001558 regulation of cell growth GO:0003013 circulatory system process GO:0003014 renal system process GO:0003015 heart process GO:0003018 vascular process in circulatory system GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006182 cGMP biosynthetic process GO:0006584 catecholamine metabolic process GO:0007168 receptor guanylyl cyclase signaling pathway GO:0007588 excretion GO:0007589 body fluid secretion GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008217 regulation of blood pressure GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009712 catechol-containing compound metabolic process GO:0016049 cell growth GO:0016525 negative regulation of angiogenesis GO:0018958 phenol-containing compound metabolic process GO:0030308 negative regulation of cell growth GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030823 regulation of cGMP metabolic process GO:0030825 positive regulation of cGMP metabolic process GO:0030826 regulation of cGMP biosynthetic process GO:0030828 positive regulation of cGMP biosynthetic process GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0033002 muscle cell proliferation GO:0035150 regulation of tube size GO:0035637 multicellular organismal signaling GO:0035809 regulation of urine volume GO:0035810 positive regulation of urine volume GO:0035812 renal sodium excretion GO:0035813 regulation of renal sodium excretion GO:0035815 positive regulation of renal sodium excretion GO:0042311 vasodilation GO:0042312 regulation of vasodilation GO:0042417 dopamine metabolic process GO:0043114 regulation of vascular permeability GO:0044057 regulation of system process GO:0044062 regulation of excretion GO:0045765 regulation of angiogenesis GO:0045926 negative regulation of growth GO:0045981 positive regulation of nucleotide metabolic process GO:0046068 cGMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0048514 blood vessel morphogenesis GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048662 negative regulation of smooth muscle cell proliferation GO:0050878 regulation of body fluid levels GO:0050880 regulation of blood vessel size GO:0051047 positive regulation of secretion GO:0052652 cyclic purine nucleotide metabolic process GO:0055067 monovalent inorganic cation homeostasis GO:0055078 sodium ion homeostasis GO:0060047 heart contraction GO:0061337 cardiac conduction GO:0072522 purine-containing compound biosynthetic process GO:0090066 regulation of anatomical structure size GO:0098801 regulation of renal system process GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1901615 organic hydroxy compound metabolic process GO:1903522 regulation of blood circulation GO:1903779 regulation of cardiac conduction GO:2000021 regulation of ion homeostasis GO:2000181 negative regulation of blood vessel morphogenesis |
Molecular Function |
GO:0001653 peptide receptor activity GO:0004383 guanylate cyclase activity GO:0005525 GTP binding GO:0008528 G-protein coupled peptide receptor activity GO:0009975 cyclase activity GO:0016829 lyase activity GO:0016849 phosphorus-oxygen lyase activity GO:0016941 natriuretic peptide receptor activity GO:0017046 peptide hormone binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding GO:0033218 amide binding GO:0042277 peptide binding GO:0042562 hormone binding |
Cellular Component |
GO:0008074 guanylate cyclase complex, soluble GO:0043235 receptor complex GO:0044445 cytosolic part |
KEGG |
hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04270 Vascular smooth muscle contraction hsa04921 Oxytocin signaling pathway hsa00230 Purine metabolism |
Reactome |
R-HSA-5576891: Cardiac conduction R-HSA-397014: Muscle contraction R-HSA-5578768: Physiological factors |
Summary | |
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Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NPR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NPR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NPR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of NPR1 in various data sets.
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Summary | |
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Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NPR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NPR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NPR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NPR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NPR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NPR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NPR1 |
Name | natriuretic peptide receptor 1 |
Aliases | GUCY2A; ANPa; guanylate cyclase A; ANPRA; NPRA; atrionatriuretic peptide receptor A; natriuretic peptide rec ...... |
Chromosomal Location | 1q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NPR1 collected from DrugBank database. |
Details on drugs targeting NPR1.
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