Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00104 Ligand-binding domain of nuclear hormone receptor PF00105 Zinc finger |
Function |
Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001819 positive regulation of cytokine production GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002279 mast cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002367 cytokine production involved in immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002448 mast cell mediated immunity GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0003012 muscle system process GO:0003300 cardiac muscle hypertrophy GO:0006090 pyruvate metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006631 fatty acid metabolic process GO:0006887 exocytosis GO:0006979 response to oxidative stress GO:0007159 leukocyte cell-cell adhesion GO:0007369 gastrulation GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007423 sensory organ development GO:0007498 mesoderm development GO:0007631 feeding behavior GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009444 pyruvate oxidation GO:0009755 hormone-mediated signaling pathway GO:0010035 response to inorganic substance GO:0010565 regulation of cellular ketone metabolic process GO:0010611 regulation of cardiac muscle hypertrophy GO:0010613 positive regulation of cardiac muscle hypertrophy GO:0010827 regulation of glucose transport GO:0010828 positive regulation of glucose transport GO:0014742 positive regulation of muscle hypertrophy GO:0014743 regulation of muscle hypertrophy GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0015980 energy derivation by oxidation of organic compounds GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0019395 fatty acid oxidation GO:0021537 telencephalon development GO:0021543 pallium development GO:0021761 limbic system development GO:0021766 hippocampus development GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030258 lipid modification GO:0030522 intracellular receptor signaling pathway GO:0030534 adult behavior GO:0030900 forebrain development GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0032418 lysosome localization GO:0032762 mast cell cytokine production GO:0032763 regulation of mast cell cytokine production GO:0032765 positive regulation of mast cell cytokine production GO:0032844 regulation of homeostatic process GO:0033002 muscle cell proliferation GO:0033003 regulation of mast cell activation GO:0033005 positive regulation of mast cell activation GO:0034440 lipid oxidation GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0035239 tube morphogenesis GO:0035726 common myeloid progenitor cell proliferation GO:0036473 cell death in response to oxidative stress GO:0036474 cell death in response to hydrogen peroxide GO:0036475 neuron death in response to oxidative stress GO:0036476 neuron death in response to hydrogen peroxide GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0038097 positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway GO:0042180 cellular ketone metabolic process GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042542 response to hydrogen peroxide GO:0043299 leukocyte degranulation GO:0043303 mast cell degranulation GO:0043401 steroid hormone mediated signaling pathway GO:0043434 response to peptide hormone GO:0043435 response to corticotropin-releasing hormone GO:0043500 muscle adaptation GO:0043502 regulation of muscle adaptation GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043583 ear development GO:0044057 regulation of system process GO:0044320 cellular response to leptin stimulus GO:0044321 response to leptin GO:0044342 type B pancreatic cell proliferation GO:0044708 single-organism behavior GO:0045055 regulated exocytosis GO:0045333 cellular respiration GO:0045444 fat cell differentiation GO:0045576 mast cell activation GO:0045785 positive regulation of cell adhesion GO:0045787 positive regulation of cell cycle GO:0045834 positive regulation of lipid metabolic process GO:0045923 positive regulation of fatty acid metabolic process GO:0046320 regulation of fatty acid oxidation GO:0046321 positive regulation of fatty acid oxidation GO:0048332 mesoderm morphogenesis GO:0048520 positive regulation of behavior GO:0048545 response to steroid hormone GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048752 semicircular canal morphogenesis GO:0048839 inner ear development GO:0048871 multicellular organismal homeostasis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050795 regulation of behavior GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050885 neuromuscular process controlling balance GO:0050905 neuromuscular process GO:0051402 neuron apoptotic process GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0060004 reflex GO:0060005 vestibular reflex GO:0060259 regulation of feeding behavior GO:0060872 semicircular canal development GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061082 myeloid leukocyte cytokine production GO:0061469 regulation of type B pancreatic cell proliferation GO:0061564 axon development GO:0070301 cellular response to hydrogen peroxide GO:0070486 leukocyte aggregation GO:0070487 monocyte aggregation GO:0070997 neuron death GO:0071375 cellular response to peptide hormone stimulus GO:0071376 cellular response to corticotropin-releasing hormone stimulus GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071867 response to monoamine GO:0071868 cellular response to monoamine stimulus GO:0071869 response to catecholamine GO:0071870 cellular response to catecholamine stimulus GO:0071887 leukocyte apoptotic process GO:0090257 regulation of muscle system process GO:0090596 sensory organ morphogenesis GO:0097009 energy homeostasis GO:0097485 neuron projection guidance GO:1900407 regulation of cellular response to oxidative stress GO:1900408 negative regulation of cellular response to oxidative stress GO:1900623 regulation of monocyte aggregation GO:1900625 positive regulation of monocyte aggregation GO:1901031 regulation of response to reactive oxygen species GO:1901032 negative regulation of response to reactive oxygen species GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902882 regulation of response to oxidative stress GO:1902883 negative regulation of response to oxidative stress GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903201 regulation of oxidative stress-induced cell death GO:1903202 negative regulation of oxidative stress-induced cell death GO:1903203 regulation of oxidative stress-induced neuron death GO:1903204 negative regulation of oxidative stress-induced neuron death GO:1903205 regulation of hydrogen peroxide-induced cell death GO:1903206 negative regulation of hydrogen peroxide-induced cell death GO:1903207 regulation of hydrogen peroxide-induced neuron death GO:1903208 negative regulation of hydrogen peroxide-induced neuron death GO:2000106 regulation of leukocyte apoptotic process GO:2000108 positive regulation of leukocyte apoptotic process GO:2000253 positive regulation of feeding behavior GO:2000505 regulation of energy homeostasis |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001221 transcription cofactor binding GO:0001223 transcription coactivator binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003707 steroid hormone receptor activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004887 thyroid hormone receptor activity GO:0008134 transcription factor binding GO:0035035 histone acetyltransferase binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0035259 glucocorticoid receptor binding GO:0051427 hormone receptor binding GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0042629 mast cell granule |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-383280: Nuclear Receptor transcription pathway |
Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NR4A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NR4A3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NR4A3 in various data sets.
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Points in the above scatter plot represent the mutation difference of NR4A3 in various data sets.
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Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NR4A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NR4A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NR4A3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NR4A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NR4A3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NR4A3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NR4A3 |
Name | nuclear receptor subfamily 4, group A, member 3 |
Aliases | CSMF; MINOR; chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; ne ...... |
Chromosomal Location | 9q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NR4A3 collected from DrugBank database. |
Details on drugs targeting NR4A3.
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