Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Cytoplasmic vesicle Cytoplasmic vesicle, autophagosome |
Domain |
PF08961 Nuclear receptor-binding factor 2 PF17169 MIT domain of nuclear receptor-binding factor 2 |
Function |
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). ; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). |
Biological Process |
GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006914 autophagy GO:0010506 regulation of autophagy GO:0019216 regulation of lipid metabolic process GO:0034976 response to endoplasmic reticulum stress GO:0043550 regulation of lipid kinase activity |
Molecular Function | - |
Cellular Component |
GO:0005776 autophagosome GO:0005942 phosphatidylinositol 3-kinase complex GO:0019898 extrinsic component of membrane GO:0035032 phosphatidylinositol 3-kinase complex, class III GO:0061695 transferase complex, transferring phosphorus-containing groups |
KEGG |
hsa04140 Regulation of autophagy |
Reactome |
R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-383280: Nuclear Receptor transcription pathway |
Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NRBF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NRBF2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NRBF2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NRBF2 in various data sets.
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Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NRBF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NRBF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NRBF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NRBF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NRBF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NRBF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NRBF2 |
Name | nuclear receptor binding factor 2 |
Aliases | DKFZp564C1664; FLJ30395; COPR1; COPR2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; COPR; N ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NRBF2 collected from DrugBank database. |
There is no record. |