Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted. |
Domain |
PF00431 CUB domain PF11980 C-terminal domain of neuropilin glycoprotein PF00754 F5/8 type C domain PF00629 MAM domain |
Function |
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). ; FUNCTION: The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. |
Biological Process |
GO:0001525 angiogenesis GO:0001558 regulation of cell growth GO:0001569 patterning of blood vessels GO:0001654 eye development GO:0001655 urogenital system development GO:0001667 ameboidal-type cell migration GO:0001708 cell fate specification GO:0001755 neural crest cell migration GO:0001763 morphogenesis of a branching structure GO:0001764 neuron migration GO:0001822 kidney development GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0003002 regionalization GO:0003158 endothelium development GO:0006929 substrate-dependent cell migration GO:0007350 blastoderm segmentation GO:0007389 pattern specification process GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007413 axonal fasciculation GO:0007423 sensory organ development GO:0007431 salivary gland development GO:0007435 salivary gland morphogenesis GO:0007507 heart development GO:0008037 cell recognition GO:0008038 neuron recognition GO:0008045 motor neuron axon guidance GO:0008361 regulation of cell size GO:0009880 embryonic pattern specification GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0014812 muscle cell migration GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014911 positive regulation of smooth muscle cell migration GO:0016049 cell growth GO:0016358 dendrite development GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0021536 diencephalon development GO:0021537 telencephalon development GO:0021543 pallium development GO:0021545 cranial nerve development GO:0021559 trigeminal nerve development GO:0021561 facial nerve development GO:0021562 vestibulocochlear nerve development GO:0021602 cranial nerve morphogenesis GO:0021604 cranial nerve structural organization GO:0021610 facial nerve morphogenesis GO:0021612 facial nerve structural organization GO:0021636 trigeminal nerve morphogenesis GO:0021637 trigeminal nerve structural organization GO:0021648 vestibulocochlear nerve morphogenesis GO:0021649 vestibulocochlear nerve structural organization GO:0021675 nerve development GO:0021761 limbic system development GO:0021783 preganglionic parasympathetic fiber development GO:0021785 branchiomotor neuron axon guidance GO:0021795 cerebral cortex cell migration GO:0021800 cerebral cortex tangential migration GO:0021824 cerebral cortex tangential migration using cell-axon interactions GO:0021825 substrate-dependent cerebral cortex tangential migration GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021854 hypothalamus development GO:0021855 hypothalamus cell migration GO:0021856 hypothalamic tangential migration using cell-axon interactions GO:0021872 forebrain generation of neurons GO:0021879 forebrain neuron differentiation GO:0021884 forebrain neuron development GO:0021885 forebrain cell migration GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron development GO:0021953 central nervous system neuron differentiation GO:0021954 central nervous system neuron development GO:0021979 hypothalamus cell differentiation GO:0021987 cerebral cortex development GO:0022029 telencephalon cell migration GO:0022604 regulation of cell morphogenesis GO:0022612 gland morphogenesis GO:0030307 positive regulation of cell growth GO:0030308 negative regulation of cell growth GO:0030335 positive regulation of cell migration GO:0030516 regulation of axon extension GO:0030517 negative regulation of axon extension GO:0030900 forebrain development GO:0031290 retinal ganglion cell axon guidance GO:0031345 negative regulation of cell projection organization GO:0031346 positive regulation of cell projection organization GO:0032092 positive regulation of protein binding GO:0032102 negative regulation of response to external stimulus GO:0032103 positive regulation of response to external stimulus GO:0032535 regulation of cellular component size GO:0035239 tube morphogenesis GO:0035272 exocrine system development GO:0035282 segmentation GO:0035290 trunk segmentation GO:0035728 response to hepatocyte growth factor GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0035767 endothelial cell chemotaxis GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0036010 protein localization to endosome GO:0036484 trunk neural crest cell migration GO:0036486 ventral trunk neural crest cell migration GO:0038084 vascular endothelial growth factor signaling pathway GO:0038189 neuropilin signaling pathway GO:0038190 VEGF-activated neuropilin signaling pathway GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0043010 camera-type eye development GO:0043393 regulation of protein binding GO:0043410 positive regulation of MAPK cascade GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043534 blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0045165 cell fate commitment GO:0045446 endothelial cell differentiation GO:0045665 negative regulation of neuron differentiation GO:0045666 positive regulation of neuron differentiation GO:0045773 positive regulation of axon extension GO:0045926 negative regulation of growth GO:0045927 positive regulation of growth GO:0048008 platelet-derived growth factor receptor signaling pathway GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048012 hepatocyte growth factor receptor signaling pathway GO:0048483 autonomic nervous system development GO:0048485 sympathetic nervous system development GO:0048486 parasympathetic nervous system development GO:0048514 blood vessel morphogenesis GO:0048532 anatomical structure arrangement GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048732 gland development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0048841 regulation of axon extension involved in axon guidance GO:0048842 positive regulation of axon extension involved in axon guidance GO:0048843 negative regulation of axon extension involved in axon guidance GO:0048844 artery morphogenesis GO:0048846 axon extension involved in axon guidance GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050771 negative regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0050918 positive chemotaxis GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0050922 negative regulation of chemotaxis GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051402 neuron apoptotic process GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0060041 retina development in camera-type eye GO:0060300 regulation of cytokine activity GO:0060301 positive regulation of cytokine activity GO:0060326 cell chemotaxis GO:0060384 innervation GO:0060385 axonogenesis involved in innervation GO:0060445 branching involved in salivary gland morphogenesis GO:0060485 mesenchyme development GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060600 dichotomous subdivision of an epithelial terminal unit GO:0060627 regulation of vesicle-mediated transport GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching GO:0060837 blood vessel endothelial cell differentiation GO:0060839 endothelial cell fate commitment GO:0060840 artery development GO:0060846 blood vessel endothelial cell fate commitment GO:0060847 endothelial cell fate specification GO:0060976 coronary vasculature development GO:0060977 coronary vasculature morphogenesis GO:0060978 angiogenesis involved in coronary vascular morphogenesis GO:0060982 coronary artery morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061298 retina vasculature development in camera-type eye GO:0061299 retina vasculature morphogenesis in camera-type eye GO:0061387 regulation of extent of cell growth GO:0061437 renal system vasculature development GO:0061438 renal system vasculature morphogenesis GO:0061439 kidney vasculature morphogenesis GO:0061440 kidney vasculature development GO:0061441 renal artery morphogenesis GO:0061548 ganglion development GO:0061549 sympathetic ganglion development GO:0061550 cranial ganglion development GO:0061551 trigeminal ganglion development GO:0061552 ganglion morphogenesis GO:0061564 axon development GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070997 neuron death GO:0071526 semaphorin-plexin signaling pathway GO:0071679 commissural neuron axon guidance GO:0071696 ectodermal placode development GO:0072001 renal system development GO:0072148 epithelial cell fate commitment GO:0072665 protein localization to vacuole GO:0090066 regulation of anatomical structure size GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090259 regulation of retinal ganglion cell axon guidance GO:0097101 blood vessel endothelial cell fate specification GO:0097102 endothelial tip cell fate specification GO:0097191 extrinsic apoptotic signaling pathway GO:0097374 sensory neuron axon guidance GO:0097485 neuron projection guidance GO:0097490 sympathetic neuron projection extension GO:0097491 sympathetic neuron projection guidance GO:1900120 regulation of receptor binding GO:1900122 positive regulation of receptor binding GO:1901166 neural crest cell migration involved in autonomic nervous system development GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901998 toxin transport GO:1902284 neuron projection extension involved in neuron projection guidance GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance GO:1902336 positive regulation of retinal ganglion cell axon guidance GO:1902378 VEGF-activated neuropilin signaling pathway involved in axon guidance GO:1902667 regulation of axon guidance GO:1902668 negative regulation of axon guidance GO:1902669 positive regulation of axon guidance GO:1902946 protein localization to early endosome GO:1903375 facioacoustic ganglion development GO:1904835 dorsal root ganglion morphogenesis GO:1905040 otic placode development GO:1990138 neuron projection extension GO:1990791 dorsal root ganglion development GO:2000147 positive regulation of cell motility GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0005021 vascular endothelial growth factor-activated receptor activity GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0015026 coreceptor activity GO:0017154 semaphorin receptor activity GO:0019199 transmembrane receptor protein kinase activity GO:0019838 growth factor binding GO:0019955 cytokine binding GO:0038085 vascular endothelial growth factor binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0002116 semaphorin receptor complex GO:0005769 early endosome GO:0005882 intermediate filament GO:0005883 neurofilament GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0030424 axon GO:0030426 growth cone GO:0030427 site of polarized growth GO:0043025 neuronal cell body GO:0043235 receptor complex GO:0044297 cell body GO:0045111 intermediate filament cytoskeleton GO:0097443 sorting endosome |
KEGG |
hsa04360 Axon guidance |
Reactome |
R-HSA-422475: Axon guidance R-HSA-447041: CHL1 interactions R-HSA-399956: CRMPs in Sema3A signaling R-HSA-1266738: Developmental Biology R-HSA-373760: L1CAM interactions R-HSA-194306: Neurophilin interactions with VEGF and VEGFR R-HSA-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399954: Sema3A PAK dependent Axon repulsion R-HSA-373755: Semaphorin interactions R-HSA-162582: Signal Transduction R-HSA-445144: Signal transduction by L1 R-HSA-194138: Signaling by VEGF |
Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NRP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NRP1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NRP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NRP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of NRP1 in various data sets.
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Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NRP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NRP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NRP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NRP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NRP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NRP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NRP1 |
Name | neuropilin 1 |
Aliases | VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ...... |
Chromosomal Location | 10p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NRP1 collected from DrugBank database. |
Details on drugs targeting NRP1.
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