Summary | |
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Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass membrane protein Lipid droplet Note=Trafficking through the Golgi is necessary for ER membrane localization. |
Domain |
PF01073 3-beta hydroxysteroid dehydrogenase/isomerase family |
Function |
Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. |
Biological Process |
GO:0001701 in utero embryonic development GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0001942 hair follicle development GO:0006066 alcohol metabolic process GO:0006694 steroid biosynthetic process GO:0006695 cholesterol biosynthetic process GO:0007224 smoothened signaling pathway GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0008544 epidermis development GO:0016125 sterol metabolic process GO:0016126 sterol biosynthetic process GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0042303 molting cycle GO:0042633 hair cycle GO:0043588 skin development GO:0044283 small molecule biosynthetic process GO:0046165 alcohol biosynthetic process GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0060674 placenta blood vessel development GO:0060711 labyrinthine layer development GO:0060716 labyrinthine layer blood vessel development GO:0061458 reproductive system development GO:0098773 skin epidermis development GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902652 secondary alcohol metabolic process GO:1902653 secondary alcohol biosynthetic process |
Molecular Function |
GO:0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0016229 steroid dehydrogenase activity GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0047012 sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity |
Cellular Component |
GO:0005811 lipid particle |
KEGG |
hsa00100 Steroid biosynthesis hsa01100 Metabolic pathways |
Reactome |
R-HSA-191273: Cholesterol biosynthesis R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins |
Summary | |
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Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NSDHL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NSDHL in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NSDHL in various data sets.
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Points in the above scatter plot represent the mutation difference of NSDHL in various data sets.
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Summary | |
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Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NSDHL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NSDHL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NSDHL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NSDHL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NSDHL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NSDHL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NSDHL |
Name | NAD(P) dependent steroid dehydrogenase-like |
Aliases | XAP104; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; protein H105e3; Sterol-4- ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NSDHL collected from DrugBank database. |
Details on drugs targeting NSDHL.
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