Browse NTF3

Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00243 Nerve growth factor family
Function

Seems to promote the survival of visceral and proprioceptive sensory neurons.

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0001933 negative regulation of protein phosphorylation
GO:0002090 regulation of receptor internalization
GO:0002092 positive regulation of receptor internalization
GO:0006898 receptor-mediated endocytosis
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018212 peptidyl-tyrosine modification
GO:0030100 regulation of endocytosis
GO:0030335 positive regulation of cell migration
GO:0031532 actin cytoskeleton reorganization
GO:0031623 receptor internalization
GO:0032103 positive regulation of response to external stimulus
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033674 positive regulation of kinase activity
GO:0040017 positive regulation of locomotion
GO:0042326 negative regulation of phosphorylation
GO:0043112 receptor metabolic process
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045807 positive regulation of endocytosis
GO:0045860 positive regulation of protein kinase activity
GO:0048259 regulation of receptor-mediated endocytosis
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0050926 regulation of positive chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051272 positive regulation of cellular component movement
GO:0051402 neuron apoptotic process
GO:0051493 regulation of cytoskeleton organization
GO:0051495 positive regulation of cytoskeleton organization
GO:0060627 regulation of vesicle-mediated transport
GO:0070997 neuron death
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090630 activation of GTPase activity
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:2000147 positive regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000251 positive regulation of actin cytoskeleton reorganization
Molecular Function GO:0005126 cytokine receptor binding
GO:0005165 neurotrophin receptor binding
GO:0005166 neurotrophin p75 receptor binding
GO:0008083 growth factor activity
GO:0042056 chemoattractant activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04722 Neurotrophin signaling pathway
Reactome -
Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NTF3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between NTF3 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23001042Breast carcinomaInhibit immunityEctopic expression of NT-3 in EMT-like breast cancer cells reduces their migratory ability and increases the expression of HER2 (human epidermal growth factor receptor 2) and E-cadherin at the cell-cell junction. In summary, NT-3 appears to promote growth of metastatic breast cancer cells in the brain by facilitating the re-epithelialization of metastatic breast cancer cells and downmodulating the cytotoxic response of microglia.
Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NTF3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NTF3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8640.0212
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.8880.00246
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1240.82
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3320.378
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4320.629
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2030.841
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.5590.446
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6050.63
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.9680.117
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7540.235
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.9060.0177
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.040.84
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NTF3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NTF3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NTF3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NTF3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NTF3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NTF3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NTF3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNTF3
Nameneurotrophin 3
Aliases NGF2; HDNF; NGF-2; NT-3; nerve growth factor 2; Neurotrophin-3
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NTF3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.