Summary | |
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Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00069 Protein kinase domain |
Function |
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1. |
Biological Process |
GO:0009267 cellular response to starvation GO:0009991 response to extracellular stimulus GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0042149 cellular response to glucose starvation GO:0042594 response to starvation GO:0071496 cellular response to external stimulus |
Molecular Function |
GO:0000287 magnesium ion binding GO:0004674 protein serine/threonine kinase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NUAK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NUAK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NUAK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NUAK2 in various data sets.
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Summary | |
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Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUAK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUAK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUAK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUAK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NUAK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NUAK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NUAK2 |
Name | NUAK family, SNF1-like kinase, 2 |
Aliases | SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NUAK2 collected from DrugBank database. |
There is no record. |