Browse NUAK2

Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00069 Protein kinase domain
Function

Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.

> Gene Ontology
 
Biological Process GO:0009267 cellular response to starvation
GO:0009991 response to extracellular stimulus
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0042149 cellular response to glucose starvation
GO:0042594 response to starvation
GO:0071496 cellular response to external stimulus
Molecular Function GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NUAK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NUAK2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen Total # shRNA with >= 4-fold: 3 Resistant to T-cell proliferation
Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NUAK2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3330.41
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5620.49
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1670.798
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0450.916
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3850.787
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5940.759
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.810.0326
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.1820.135
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4220.623
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.9920.369
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9590.531
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3520.0338
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NUAK2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.12.78.40.12
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.13.47.70.176
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUAK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUAK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUAK2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUAK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NUAK2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NUAK2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNUAK2
NameNUAK family, SNF1-like kinase, 2
Aliases SNARK; FLJ90349; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2; NU ......
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NUAK2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.