Summary | |
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Symbol | NUDCD2 |
Name | NudC domain containing 2 |
Aliases | DKFZp686E10109; NudC-like protein 2; NudC domain-containing protein 2 |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis. |
Domain |
PF04969 CS domain |
Function |
May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. |
Biological Process |
GO:0006457 protein folding |
Molecular Function |
GO:0051082 unfolded protein binding |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000793 condensed chromosome GO:0000922 spindle pole GO:0005819 spindle GO:0098687 chromosomal region |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | NUDCD2 |
Name | NudC domain containing 2 |
Aliases | DKFZp686E10109; NudC-like protein 2; NudC domain-containing protein 2 |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NUDCD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NUDCD2 |
Name | NudC domain containing 2 |
Aliases | DKFZp686E10109; NudC-like protein 2; NudC domain-containing protein 2 |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NUDCD2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | NUDCD2 |
Name | NudC domain containing 2 |
Aliases | DKFZp686E10109; NudC-like protein 2; NudC domain-containing protein 2 |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NUDCD2 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | NUDCD2 |
Name | NudC domain containing 2 |
Aliases | DKFZp686E10109; NudC-like protein 2; NudC domain-containing protein 2 |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUDCD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NUDCD2 |
Name | NudC domain containing 2 |
Aliases | DKFZp686E10109; NudC-like protein 2; NudC domain-containing protein 2 |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUDCD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUDCD2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NUDCD2 |
Name | NudC domain containing 2 |
Aliases | DKFZp686E10109; NudC-like protein 2; NudC domain-containing protein 2 |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUDCD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NUDCD2 |
Name | NudC domain containing 2 |
Aliases | DKFZp686E10109; NudC-like protein 2; NudC domain-containing protein 2 |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NUDCD2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NUDCD2 |
Name | NudC domain containing 2 |
Aliases | DKFZp686E10109; NudC-like protein 2; NudC domain-containing protein 2 |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NUDCD2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |