Summary | |
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Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF00293 NUDIX domain |
Function |
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006152 purine nucleoside catabolic process GO:0006195 purine nucleotide catabolic process GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009125 nucleoside monophosphate catabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009128 purine nucleoside monophosphate catabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009154 purine ribonucleotide catabolic process GO:0009158 ribonucleoside monophosphate catabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009164 nucleoside catabolic process GO:0009166 nucleotide catabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009169 purine ribonucleoside monophosphate catabolic process GO:0009261 ribonucleotide catabolic process GO:0015959 diadenosine polyphosphate metabolic process GO:0015961 diadenosine polyphosphate catabolic process GO:0019439 aromatic compound catabolic process GO:0019751 polyol metabolic process GO:0034655 nucleobase-containing compound catabolic process GO:0042278 purine nucleoside metabolic process GO:0042454 ribonucleoside catabolic process GO:0043647 inositol phosphate metabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046130 purine ribonucleoside catabolic process GO:0046434 organophosphate catabolic process GO:0046700 heterocycle catabolic process GO:0071543 diphosphoinositol polyphosphate metabolic process GO:0072523 purine-containing compound catabolic process GO:1901136 carbohydrate derivative catabolic process GO:1901292 nucleoside phosphate catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process GO:1901615 organic hydroxy compound metabolic process GO:1901657 glycosyl compound metabolic process GO:1901658 glycosyl compound catabolic process GO:1901906 diadenosine pentaphosphate metabolic process GO:1901907 diadenosine pentaphosphate catabolic process GO:1901908 diadenosine hexaphosphate metabolic process GO:1901909 diadenosine hexaphosphate catabolic process GO:1901910 adenosine 5'-(hexahydrogen pentaphosphate) metabolic process GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process |
Molecular Function |
GO:0000298 endopolyphosphatase activity GO:0004551 nucleotide diphosphatase activity GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity GO:0050072 m7G(5')pppN diphosphatase activity GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity GO:0052841 inositol bisdiphosphate tetrakisphosphate diphosphatase activity GO:0052842 inositol diphosphate pentakisphosphate diphosphatase activity GO:0052843 inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity GO:0052844 inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity GO:0052846 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity GO:0052848 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1483249: Inositol phosphate metabolism R-HSA-1430728: Metabolism R-HSA-1855167: Synthesis of pyrophosphates in the cytosol |
Summary | |
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Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NUDT11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NUDT11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NUDT11 in various data sets.
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Points in the above scatter plot represent the mutation difference of NUDT11 in various data sets.
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Summary | |
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Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUDT11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUDT11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUDT11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUDT11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NUDT11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NUDT11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NUDT11 |
Name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 |
Aliases | DIPP3b; FLJ10628; hDIPP3beta; DIPP3beta; DIPP-3-beta; DIPP3-beta; diadenosine 5',5'''-P1,P6-hexaphosphate hy ...... |
Chromosomal Location | Xp11.22-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NUDT11 collected from DrugBank database. |
There is no record. |