Summary | |
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Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Peripheral membrane protein. |
Domain |
PF06311 NUMB domain PF00640 Phosphotyrosine interaction domain (PTB/PID) |
Function |
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. |
Biological Process |
GO:0001738 morphogenesis of a polarized epithelium GO:0007009 plasma membrane organization GO:0007219 Notch signaling pathway GO:0007405 neuroblast proliferation GO:0007409 axonogenesis GO:0008593 regulation of Notch signaling pathway GO:0010720 positive regulation of cell development GO:0017145 stem cell division GO:0021537 telencephalon development GO:0021591 ventricular system development GO:0021670 lateral ventricle development GO:0021846 cell proliferation in forebrain GO:0021849 neuroblast division in subventricular zone GO:0021872 forebrain generation of neurons GO:0021873 forebrain neuroblast division GO:0030323 respiratory tube development GO:0030324 lung development GO:0030335 positive regulation of cell migration GO:0030856 regulation of epithelial cell differentiation GO:0030858 positive regulation of epithelial cell differentiation GO:0030859 polarized epithelial cell differentiation GO:0030860 regulation of polarized epithelial cell differentiation GO:0030862 positive regulation of polarized epithelial cell differentiation GO:0030900 forebrain development GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0036445 neuronal stem cell division GO:0040017 positive regulation of locomotion GO:0045216 cell-cell junction organization GO:0045746 negative regulation of Notch signaling pathway GO:0048103 somatic stem cell division GO:0048667 cell morphogenesis involved in neuron differentiation GO:0050769 positive regulation of neurogenesis GO:0051272 positive regulation of cellular component movement GO:0051962 positive regulation of nervous system development GO:0055057 neuroblast division GO:0060428 lung epithelium development GO:0060479 lung cell differentiation GO:0060487 lung epithelial cell differentiation GO:0060541 respiratory system development GO:0061351 neural precursor cell proliferation GO:0061564 axon development GO:0072089 stem cell proliferation GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:1903076 regulation of protein localization to plasma membrane GO:1903077 negative regulation of protein localization to plasma membrane GO:1903729 regulation of plasma membrane organization GO:1903828 negative regulation of cellular protein localization GO:1904375 regulation of protein localization to cell periphery GO:1904376 negative regulation of protein localization to cell periphery GO:1905330 regulation of morphogenesis of an epithelium GO:1905332 positive regulation of morphogenesis of an epithelium GO:1990778 protein localization to cell periphery GO:2000027 regulation of organ morphogenesis GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0008013 beta-catenin binding GO:0045294 alpha-catenin binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005769 early endosome GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0016323 basolateral plasma membrane GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0030055 cell-substrate junction GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0045177 apical part of cell |
KEGG |
hsa04330 Notch signaling pathway |
Reactome |
R-HSA-2122948: Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-422475: Axon guidance R-HSA-5610780: Degradation of GLI1 by the proteasome R-HSA-1266738: Developmental Biology R-HSA-5610787: Hedgehog 'off' state R-HSA-5632684: Hedgehog 'on' state R-HSA-373760: L1CAM interactions R-HSA-437239: Recycling pathway of L1 R-HSA-162582: Signal Transduction R-HSA-5358351: Signaling by Hedgehog R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 |
Summary | |
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Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NUMB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NUMB and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NUMB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NUMB in various data sets.
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Points in the above scatter plot represent the mutation difference of NUMB in various data sets.
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Summary | |
---|---|
Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUMB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUMB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUMB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUMB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NUMB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NUMB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NUMB |
Name | numb homolog (Drosophila) |
Aliases | C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NUMB collected from DrugBank database. |
There is no record. |