Browse NUMB

Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Peripheral membrane protein.
Domain PF06311 NUMB domain
PF00640 Phosphotyrosine interaction domain (PTB/PID)
Function

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

> Gene Ontology
 
Biological Process GO:0001738 morphogenesis of a polarized epithelium
GO:0007009 plasma membrane organization
GO:0007219 Notch signaling pathway
GO:0007405 neuroblast proliferation
GO:0007409 axonogenesis
GO:0008593 regulation of Notch signaling pathway
GO:0010720 positive regulation of cell development
GO:0017145 stem cell division
GO:0021537 telencephalon development
GO:0021591 ventricular system development
GO:0021670 lateral ventricle development
GO:0021846 cell proliferation in forebrain
GO:0021849 neuroblast division in subventricular zone
GO:0021872 forebrain generation of neurons
GO:0021873 forebrain neuroblast division
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030859 polarized epithelial cell differentiation
GO:0030860 regulation of polarized epithelial cell differentiation
GO:0030862 positive regulation of polarized epithelial cell differentiation
GO:0030900 forebrain development
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0036445 neuronal stem cell division
GO:0040017 positive regulation of locomotion
GO:0045216 cell-cell junction organization
GO:0045746 negative regulation of Notch signaling pathway
GO:0048103 somatic stem cell division
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050769 positive regulation of neurogenesis
GO:0051272 positive regulation of cellular component movement
GO:0051962 positive regulation of nervous system development
GO:0055057 neuroblast division
GO:0060428 lung epithelium development
GO:0060479 lung cell differentiation
GO:0060487 lung epithelial cell differentiation
GO:0060541 respiratory system development
GO:0061351 neural precursor cell proliferation
GO:0061564 axon development
GO:0072089 stem cell proliferation
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:1903076 regulation of protein localization to plasma membrane
GO:1903077 negative regulation of protein localization to plasma membrane
GO:1903729 regulation of plasma membrane organization
GO:1903828 negative regulation of cellular protein localization
GO:1904375 regulation of protein localization to cell periphery
GO:1904376 negative regulation of protein localization to cell periphery
GO:1905330 regulation of morphogenesis of an epithelium
GO:1905332 positive regulation of morphogenesis of an epithelium
GO:1990778 protein localization to cell periphery
GO:2000027 regulation of organ morphogenesis
GO:2000147 positive regulation of cell motility
Molecular Function GO:0008013 beta-catenin binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005769 early endosome
GO:0005913 cell-cell adherens junction
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0016323 basolateral plasma membrane
GO:0019897 extrinsic component of plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030055 cell-substrate junction
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0045177 apical part of cell
> KEGG and Reactome Pathway
 
KEGG hsa04330 Notch signaling pathway
Reactome R-HSA-2122948: Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-422475: Axon guidance
R-HSA-5610780: Degradation of GLI1 by the proteasome
R-HSA-1266738: Developmental Biology
R-HSA-5610787: Hedgehog 'off' state
R-HSA-5632684: Hedgehog 'on' state
R-HSA-373760: L1CAM interactions
R-HSA-437239: Recycling pathway of L1
R-HSA-162582: Signal Transduction
R-HSA-5358351: Signaling by Hedgehog
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NUMB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between NUMB and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26523864Ovarian CarcinomaInhibit immunity (T cell function)EZH2 activated the Notch pathway by suppressing Notch repressors Numb and Fbxw7 via trimethylation of histone H3 at Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling.
Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NUMB in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NUMB in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0930.744
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1090.958
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2340.869
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4410.233
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1690.94
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7930.795
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0530.896
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0890.959
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2350.905
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.260.864
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8850.692
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1090.0181
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NUMB in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUMB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUMB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUMB.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUMB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NUMB expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NUMB and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNUMB
Namenumb homolog (Drosophila)
Aliases C14orf41; numb (Drosophila) homolog; chromosome 14 open reading frame 41; S171; c14_5527; h-Numb; Protein S1 ......
Chromosomal Location14q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NUMB collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.