Browse NUMBL

Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
Domain PF06311 NUMB domain
PF00640 Phosphotyrosine interaction domain (PTB/PID)
Function

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

> Gene Ontology
 
Biological Process GO:0007405 neuroblast proliferation
GO:0007409 axonogenesis
GO:0010720 positive regulation of cell development
GO:0017145 stem cell division
GO:0021537 telencephalon development
GO:0021591 ventricular system development
GO:0021670 lateral ventricle development
GO:0021846 cell proliferation in forebrain
GO:0021849 neuroblast division in subventricular zone
GO:0021872 forebrain generation of neurons
GO:0021873 forebrain neuroblast division
GO:0030900 forebrain development
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0036445 neuronal stem cell division
GO:0045216 cell-cell junction organization
GO:0048103 somatic stem cell division
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050769 positive regulation of neurogenesis
GO:0051962 positive regulation of nervous system development
GO:0055057 neuroblast division
GO:0061351 neural precursor cell proliferation
GO:0061564 axon development
GO:0072089 stem cell proliferation
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04330 Notch signaling pathway
Reactome -
Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NUMBL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NUMBL in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NUMBL in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7910.0222
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.1230.453
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5480.627
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3320.37
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1390.948
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5720.835
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1380.676
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2010.854
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5460.641
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6460.542
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0310.482
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0820.361
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NUMBL in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.811.8-70.577
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUMBL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUMBL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUMBL.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUMBL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NUMBL expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NUMBL and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNUMBL
Namenumb homolog (Drosophila)-like
Aliases NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location19q13.13-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NUMBL collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.