Summary | |
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Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. |
Domain |
PF06311 NUMB domain PF00640 Phosphotyrosine interaction domain (PTB/PID) |
Function |
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. |
Biological Process |
GO:0007405 neuroblast proliferation GO:0007409 axonogenesis GO:0010720 positive regulation of cell development GO:0017145 stem cell division GO:0021537 telencephalon development GO:0021591 ventricular system development GO:0021670 lateral ventricle development GO:0021846 cell proliferation in forebrain GO:0021849 neuroblast division in subventricular zone GO:0021872 forebrain generation of neurons GO:0021873 forebrain neuroblast division GO:0030900 forebrain development GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0036445 neuronal stem cell division GO:0045216 cell-cell junction organization GO:0048103 somatic stem cell division GO:0048667 cell morphogenesis involved in neuron differentiation GO:0050769 positive regulation of neurogenesis GO:0051962 positive regulation of nervous system development GO:0055057 neuroblast division GO:0061351 neural precursor cell proliferation GO:0061564 axon development GO:0072089 stem cell proliferation |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04330 Notch signaling pathway |
Reactome | - |
Summary | |
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Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NUMBL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NUMBL in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NUMBL in various data sets.
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Points in the above scatter plot represent the mutation difference of NUMBL in various data sets.
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Summary | |
---|---|
Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUMBL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUMBL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUMBL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUMBL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NUMBL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NUMBL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NUMBL |
Name | numb homolog (Drosophila)-like |
Aliases | NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ...... |
Chromosomal Location | 19q13.13-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NUMBL collected from DrugBank database. |
There is no record. |