Browse NUP205

Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus membrane Peripheral membrane protein Nucleus, nuclear pore complex Note=Localized near the center, on both the cytoplasmic and nuclear side, of the NPC core structure.
Domain PF11894 Nuclear pore complex scaffold
Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283).

> Gene Ontology
 
Biological Process GO:0000059 protein import into nucleus, docking
GO:0006403 RNA localization
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0006997 nucleus organization
GO:0006998 nuclear envelope organization
GO:0006999 nuclear pore organization
GO:0007077 mitotic nuclear envelope disassembly
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009266 response to temperature stimulus
GO:0009408 response to heat
GO:0010827 regulation of glucose transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015931 nucleobase-containing compound transport
GO:0016458 gene silencing
GO:0016925 protein sumoylation
GO:0017038 protein import
GO:0018205 peptidyl-lysine modification
GO:0019058 viral life cycle
GO:0019080 viral gene expression
GO:0019083 viral transcription
GO:0030397 membrane disassembly
GO:0031047 gene silencing by RNA
GO:0034504 protein localization to nucleus
GO:0034605 cellular response to heat
GO:0044033 multi-organism metabolic process
GO:0044744 protein targeting to nucleus
GO:0044766 multi-organism transport
GO:0046794 transport of virus
GO:0046931 pore complex assembly
GO:0050657 nucleic acid transport
GO:0050658 RNA transport
GO:0051028 mRNA transport
GO:0051031 tRNA transport
GO:0051081 nuclear envelope disassembly
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051236 establishment of RNA localization
GO:0051292 nuclear pore complex assembly
GO:0071166 ribonucleoprotein complex localization
GO:0071426 ribonucleoprotein complex export from nucleus
GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus
GO:0071431 tRNA-containing ribonucleoprotein complex export from nucleus
GO:0075733 intracellular transport of virus
GO:1900034 regulation of cellular response to heat
GO:1902579 multi-organism localization
GO:1902581 multi-organism cellular localization
GO:1902583 multi-organism intracellular transport
GO:1902593 single-organism nuclear import
Molecular Function GO:0017056 structural constituent of nuclear pore
Cellular Component GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0031965 nuclear membrane
GO:0034399 nuclear periphery
GO:0044611 nuclear pore inner ring
> KEGG and Reactome Pathway
 
KEGG hsa03013 RNA transport
Reactome R-HSA-168276: NS1 Mediated Effects on Host Pathways
R-HSA-1169410: Antiviral mechanism by IFN-stimulated genes
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-3371556: Cellular response to heat stress
R-HSA-2262752: Cellular responses to stress
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-1643685: Disease
R-HSA-168274: Export of Viral Ribonucleoproteins from Nucleus
R-HSA-74160: Gene Expression
R-HSA-211000: Gene Silencing by RNA
R-HSA-70153: Glucose transport
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-189200: Hexose transport
R-HSA-162909: Host Interactions of HIV factors
R-HSA-168253: Host Interactions with Influenza Factors
R-HSA-1169408: ISG15 antiviral mechanism
R-HSA-168256: Immune System
R-HSA-5663205: Infectious disease
R-HSA-168254: Influenza Infection
R-HSA-168255: Influenza Life Cycle
R-HSA-168273: Influenza Viral RNA Transcription and Replication
R-HSA-177243: Interactions of Rev with host cellular proteins
R-HSA-176033: Interactions of Vpr with host cellular proteins
R-HSA-913531: Interferon Signaling
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-68886: M Phase
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-194441: Metabolism of non-coding RNA
R-HSA-392499: Metabolism of proteins
R-HSA-68875: Mitotic Prophase
R-HSA-168333: NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-2980766: Nuclear Envelope Breakdown
R-HSA-3301854: Nuclear Pore Complex (NPC) Disassembly
R-HSA-180746: Nuclear import of Rev protein
R-HSA-597592: Post-translational protein modification
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-170822: Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-3371453: Regulation of HSF1-mediated heat shock response
R-HSA-165054: Rev-mediated nuclear export of HIV RNA
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-4615885: SUMOylation of DNA replication proteins
R-HSA-4570464: SUMOylation of RNA binding proteins
R-HSA-5578749: Transcriptional regulation by small RNAs
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-72202: Transport of Mature Transcript to Cytoplasm
R-HSA-159231: Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-159234: Transport of Mature mRNAs Derived from Intronless Transcripts
R-HSA-168271: Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-159230: Transport of the SLBP Dependant Mature mRNA
R-HSA-159227: Transport of the SLBP independent Mature mRNA
R-HSA-168325: Viral Messenger RNA Synthesis
R-HSA-180910: Vpr-mediated nuclear import of PICs
R-HSA-191859: snRNP Assembly
R-HSA-72306: tRNA processing
R-HSA-6784531: tRNA processing in the nucleus
Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NUP205 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NUP205 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NUP205 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0130.961
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.540.769
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3760.788
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0490.843
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2550.908
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.210.94
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1640.69
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1140.952
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5650.775
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3760.788
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7520.721
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1230.0466
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NUP205 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.35.98.40.613
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)862516.78.31
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.93.74.20.636
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.57.15.41
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUP205. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUP205. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUP205.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUP205. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NUP205 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NUP205 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNUP205
Namenucleoporin 205kDa
Aliases KIAA0225; C7orf14; chromosome 7 open reading frame 14; 205 kDa nucleoporin; nucleoporin Nup205; Nuclear pore ......
Chromosomal Location7q31.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NUP205 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.