Browse NUP93

Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus membrane Peripheral membrane protein Nucleus, nuclear pore complex Nucleus envelope Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.
Domain PF04097 Nup93/Nic96
Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725).

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0001655 urogenital system development
GO:0001667 ameboidal-type cell migration
GO:0001822 kidney development
GO:0002064 epithelial cell development
GO:0006403 RNA localization
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0006979 response to oxidative stress
GO:0006997 nucleus organization
GO:0006998 nuclear envelope organization
GO:0006999 nuclear pore organization
GO:0007077 mitotic nuclear envelope disassembly
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007184 SMAD protein import into nucleus
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009266 response to temperature stimulus
GO:0009408 response to heat
GO:0010035 response to inorganic substance
GO:0010631 epithelial cell migration
GO:0010827 regulation of glucose transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015931 nucleobase-containing compound transport
GO:0016458 gene silencing
GO:0016925 protein sumoylation
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0017038 protein import
GO:0018205 peptidyl-lysine modification
GO:0019058 viral life cycle
GO:0019080 viral gene expression
GO:0019083 viral transcription
GO:0030397 membrane disassembly
GO:0031047 gene silencing by RNA
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032835 glomerulus development
GO:0033157 regulation of intracellular protein transport
GO:0034504 protein localization to nucleus
GO:0034599 cellular response to oxidative stress
GO:0034605 cellular response to heat
GO:0034614 cellular response to reactive oxygen species
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0036473 cell death in response to oxidative stress
GO:0036474 cell death in response to hydrogen peroxide
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042542 response to hydrogen peroxide
GO:0044033 multi-organism metabolic process
GO:0044744 protein targeting to nucleus
GO:0044766 multi-organism transport
GO:0046794 transport of virus
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0046931 pore complex assembly
GO:0050657 nucleic acid transport
GO:0050658 RNA transport
GO:0051028 mRNA transport
GO:0051031 tRNA transport
GO:0051081 nuclear envelope disassembly
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051222 positive regulation of protein transport
GO:0051236 establishment of RNA localization
GO:0051292 nuclear pore complex assembly
GO:0060390 regulation of SMAD protein import into nucleus
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060395 SMAD protein signal transduction
GO:0061005 cell differentiation involved in kidney development
GO:0061318 renal filtration cell differentiation
GO:0070301 cellular response to hydrogen peroxide
GO:0071166 ribonucleoprotein complex localization
GO:0071426 ribonucleoprotein complex export from nucleus
GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus
GO:0071431 tRNA-containing ribonucleoprotein complex export from nucleus
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072010 glomerular epithelium development
GO:0072015 glomerular visceral epithelial cell development
GO:0072073 kidney epithelium development
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072310 glomerular epithelial cell development
GO:0072311 glomerular epithelial cell differentiation
GO:0075733 intracellular transport of virus
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090316 positive regulation of intracellular protein transport
GO:0090521 glomerular visceral epithelial cell migration
GO:1900034 regulation of cellular response to heat
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1900407 regulation of cellular response to oxidative stress
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1901031 regulation of response to reactive oxygen species
GO:1901032 negative regulation of response to reactive oxygen species
GO:1902579 multi-organism localization
GO:1902581 multi-organism cellular localization
GO:1902583 multi-organism intracellular transport
GO:1902593 single-organism nuclear import
GO:1902882 regulation of response to oxidative stress
GO:1902883 negative regulation of response to oxidative stress
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903205 regulation of hydrogen peroxide-induced cell death
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903533 regulation of protein targeting
GO:1903829 positive regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904951 positive regulation of establishment of protein localization
Molecular Function GO:0017056 structural constituent of nuclear pore
Cellular Component GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0031965 nuclear membrane
GO:0034399 nuclear periphery
> KEGG and Reactome Pathway
 
KEGG hsa03013 RNA transport
Reactome R-HSA-168276: NS1 Mediated Effects on Host Pathways
R-HSA-1169410: Antiviral mechanism by IFN-stimulated genes
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-3371556: Cellular response to heat stress
R-HSA-2262752: Cellular responses to stress
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-1643685: Disease
R-HSA-168274: Export of Viral Ribonucleoproteins from Nucleus
R-HSA-74160: Gene Expression
R-HSA-211000: Gene Silencing by RNA
R-HSA-70153: Glucose transport
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-189200: Hexose transport
R-HSA-162909: Host Interactions of HIV factors
R-HSA-168253: Host Interactions with Influenza Factors
R-HSA-1169408: ISG15 antiviral mechanism
R-HSA-168256: Immune System
R-HSA-5663205: Infectious disease
R-HSA-168254: Influenza Infection
R-HSA-168255: Influenza Life Cycle
R-HSA-168273: Influenza Viral RNA Transcription and Replication
R-HSA-177243: Interactions of Rev with host cellular proteins
R-HSA-176033: Interactions of Vpr with host cellular proteins
R-HSA-913531: Interferon Signaling
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-68886: M Phase
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-194441: Metabolism of non-coding RNA
R-HSA-392499: Metabolism of proteins
R-HSA-68875: Mitotic Prophase
R-HSA-168333: NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-2980766: Nuclear Envelope Breakdown
R-HSA-3301854: Nuclear Pore Complex (NPC) Disassembly
R-HSA-180746: Nuclear import of Rev protein
R-HSA-597592: Post-translational protein modification
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-170822: Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-3371453: Regulation of HSF1-mediated heat shock response
R-HSA-165054: Rev-mediated nuclear export of HIV RNA
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-4615885: SUMOylation of DNA replication proteins
R-HSA-4570464: SUMOylation of RNA binding proteins
R-HSA-5578749: Transcriptional regulation by small RNAs
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-72202: Transport of Mature Transcript to Cytoplasm
R-HSA-159231: Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-159234: Transport of Mature mRNAs Derived from Intronless Transcripts
R-HSA-168271: Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-159230: Transport of the SLBP Dependant Mature mRNA
R-HSA-159227: Transport of the SLBP independent Mature mRNA
R-HSA-168325: Viral Messenger RNA Synthesis
R-HSA-180910: Vpr-mediated nuclear import of PICs
R-HSA-191859: snRNP Assembly
R-HSA-72306: tRNA processing
R-HSA-6784531: tRNA processing in the nucleus
Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NUP93 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NUP93 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.65 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NUP93 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1250.642
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7370.732
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3280.844
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2230.285
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4960.795
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1240.96
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0750.838
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1670.92
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4250.808
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.510.732
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.710.757
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0250.676
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NUP93 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUP93. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUP93. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUP93.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUP93. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NUP93 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NUP93 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNUP93
Namenucleoporin 93kDa
Aliases KIAA0095; NIC96; 93 kDa nucleoporin; nucleoporin Nup93; Nuclear pore complex protein Nup93
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NUP93 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.