Summary | |
---|---|
Symbol | NXF2 |
Name | nuclear RNA export factor 2 |
Aliases | TAP like protein 2 |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm. |
Domain |
PF02136 Nuclear transport factor 2 (NTF2) domain PF09162 Tap PF03943 TAP C-terminal domain |
Function |
Involved in the export of mRNA from the nucleus to the cytoplasm. |
Biological Process |
GO:0006403 RNA localization GO:0006405 RNA export from nucleus GO:0006406 mRNA export from nucleus GO:0006913 nucleocytoplasmic transport GO:0015931 nucleobase-containing compound transport GO:0016973 poly(A)+ mRNA export from nucleus GO:0050657 nucleic acid transport GO:0050658 RNA transport GO:0051028 mRNA transport GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051236 establishment of RNA localization GO:0071166 ribonucleoprotein complex localization GO:0071426 ribonucleoprotein complex export from nucleus GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus |
Molecular Function | - |
Cellular Component |
GO:0042272 nuclear RNA export factor complex |
KEGG |
hsa03008 Ribosome biogenesis in eukaryotes hsa03013 RNA transport hsa03015 mRNA surveillance pathway |
Reactome |
R-HSA-74160: Gene Expression R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA R-HSA-72202: Transport of Mature Transcript to Cytoplasm R-HSA-159236: Transport of Mature mRNA derived from an Intron-Containing Transcript |
Summary | |
---|---|
Symbol | NXF2 |
Name | nuclear RNA export factor 2 |
Aliases | TAP like protein 2 |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NXF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NXF2 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | NXF2 |
Name | nuclear RNA export factor 2 |
Aliases | TAP like protein 2 |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NXF2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | NXF2 |
Name | nuclear RNA export factor 2 |
Aliases | TAP like protein 2 |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NXF2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NXF2 in various data sets.
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Summary | |
---|---|
Symbol | NXF2 |
Name | nuclear RNA export factor 2 |
Aliases | TAP like protein 2 |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NXF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NXF2 |
Name | nuclear RNA export factor 2 |
Aliases | TAP like protein 2 |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NXF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NXF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NXF2 |
Name | nuclear RNA export factor 2 |
Aliases | TAP like protein 2 |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NXF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NXF2 |
Name | nuclear RNA export factor 2 |
Aliases | TAP like protein 2 |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NXF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NXF2 |
Name | nuclear RNA export factor 2 |
Aliases | TAP like protein 2 |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NXF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |