Summary | |
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Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF13905 Thioredoxin-like |
Function |
May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons. |
Biological Process |
GO:0001894 tissue homeostasis GO:0001895 retina homeostasis GO:0007601 visual perception GO:0007608 sensory perception of smell GO:0009636 response to toxic substance GO:0045494 photoreceptor cell maintenance GO:0048871 multicellular organismal homeostasis GO:0050953 sensory perception of light stimulus GO:0060249 anatomical structure homeostasis GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1990748 cellular detoxification |
Molecular Function |
GO:0004791 thioredoxin-disulfide reductase activity GO:0016209 antioxidant activity GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0016667 oxidoreductase activity, acting on a sulfur group of donors GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NXNL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NXNL2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NXNL2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NXNL2 in various data sets.
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Summary | |
---|---|
Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NXNL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NXNL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NXNL2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NXNL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NXNL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NXNL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NXNL2 |
Name | nucleoredoxin-like 2 |
Aliases | C9orf121; chromosome 9 open reading frame 121; RDCVF2; rod-derived cone viability factor 2; Nucleoredoxin-li ...... |
Chromosomal Location | 9q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NXNL2 collected from DrugBank database. |
There is no record. |