Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 3: Cytoplasm, myofibril, sarcomere, M line Cytoplasm, myofibril, sarcomere, Z line Note=In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk (PubMed:12527750). Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells (PubMed:12527750).; SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line Cytoplasm, myofibril, sarcomere, Z line Cell membrane, sarcolemma Nucleus Note=Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. |
Domain |
PF00041 Fibronectin type III domain PF07679 Immunoglobulin I-set domain PF00612 IQ calmodulin-binding motif PF00069 Protein kinase domain PF00621 RhoGEF domain |
Function |
Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). |
Biological Process |
GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0010927 cellular component assembly involved in morphogenesis GO:0030239 myofibril assembly GO:0031032 actomyosin structure organization GO:0035023 regulation of Rho protein signal transduction GO:0036309 protein localization to M-band GO:0042692 muscle cell differentiation GO:0045214 sarcomere organization GO:0046578 regulation of Ras protein signal transduction GO:0051056 regulation of small GTPase mediated signal transduction GO:0051146 striated muscle cell differentiation GO:0055001 muscle cell development GO:0055002 striated muscle cell development |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0005516 calmodulin binding GO:0008307 structural constituent of muscle GO:0030506 ankyrin binding GO:0031432 titin binding |
Cellular Component |
GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0031430 M band GO:0031672 A band GO:0031674 I band GO:0043292 contractile fiber GO:0044449 contractile fiber part |
KEGG | - |
Reactome |
R-HSA-204998: Cell death signalling via NRAGE, NRIF and NADE R-HSA-416482: G alpha (12/13) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-193648: NRAGE signals death through JNK R-HSA-194840: Rho GTPase cycle R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-194315: Signaling by Rho GTPases R-HSA-166520: Signalling by NGF R-HSA-193704: p75 NTR receptor-mediated signalling |
Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between OBSCN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of OBSCN in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of OBSCN in various data sets.
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Points in the above scatter plot represent the mutation difference of OBSCN in various data sets.
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Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of OBSCN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of OBSCN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by OBSCN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of OBSCN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of OBSCN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between OBSCN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | OBSCN |
Name | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | KIAA1556; UNC89; KIAA1639; ARHGEF30; obscurin, myosin light chain kinase; obscurin-MLCK; Obscurin-myosin lig ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting OBSCN collected from DrugBank database. |
There is no record. |