Summary | |
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Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome Chromosome, centromere Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. |
Domain |
PF03226 Yippee zinc-binding/DNA-binding /Mis18 |
Function |
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. |
Biological Process |
GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006338 chromatin remodeling GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0034080 CENP-A containing nucleosome assembly GO:0034508 centromere complex assembly GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0043044 ATP-dependent chromatin remodeling GO:0043486 histone exchange GO:0061641 CENP-A containing chromatin organization GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization |
Molecular Function | - |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0010369 chromocenter GO:0015030 Cajal body GO:0016604 nuclear body GO:0098687 chromosomal region |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-73886: Chromosome Maintenance R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-774815: Nucleosome assembly |
Summary | |
---|---|
Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between OIP5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of OIP5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of OIP5 in various data sets.
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Points in the above scatter plot represent the mutation difference of OIP5 in various data sets.
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Summary | |
---|---|
Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of OIP5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of OIP5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by OIP5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of OIP5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of OIP5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between OIP5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | OIP5 |
Name | Opa interacting protein 5 |
Aliases | MIS18B; hMIS18beta; CT86; MIS18 kinetochore protein homolog B (S. pombe); cancer/testis antigen 86; 5730547N ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting OIP5 collected from DrugBank database. |
There is no record. |