Summary | |
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Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Note=Isoform beta is more mobile in the plasma membrane (PubMed:23307288). Colocalizes with STIM1 at the cell membrane (PubMed:27185316). |
Domain |
PF07856 Mediator of CRAC channel activity |
Function |
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). |
Biological Process |
GO:0002115 store-operated calcium entry GO:0002250 adaptive immune response GO:0006816 calcium ion transport GO:0010959 regulation of metal ion transport GO:0043270 positive regulation of ion transport GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072511 divalent inorganic cation transport |
Molecular Function |
GO:0005216 ion channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0005516 calmodulin binding GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0015279 store-operated calcium channel activity GO:0022803 passive transmembrane transporter activity GO:0022838 substrate-specific channel activity GO:0046873 metal ion transmembrane transporter activity GO:0072509 divalent inorganic cation transmembrane transporter activity |
Cellular Component |
GO:0005776 autophagosome |
KEGG |
hsa04020 Calcium signaling pathway hsa04024 cAMP signaling pathway hsa04611 Platelet activation |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-5576891: Cardiac conduction R-HSA-139853: Elevation of cytosolic Ca2+ levels R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-5578775: Ion homeostasis R-HSA-397014: Muscle contraction R-HSA-418360: Platelet calcium homeostasis R-HSA-418346: Platelet homeostasis R-HSA-983705: Signaling by the B Cell Receptor (BCR) |
Summary | |
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Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ORAI1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ORAI1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ORAI1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ORAI1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ORAI1 in various data sets.
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Summary | |
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Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ORAI1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ORAI1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ORAI1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ORAI1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ORAI1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ORAI1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ORAI1 |
Name | ORAI calcium release-activated calcium modulator 1 |
Aliases | FLJ14466; CRACM1; calcium release-activated calcium modulator 1; TMEM142A; transmembrane protein 142A; IMD9; ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ORAI1 collected from DrugBank database. |
There is no record. |