Browse ORM1

Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00061 Lipocalin / cytosolic fatty-acid binding protein family
Function

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

> Gene Ontology
 
Biological Process GO:0001818 negative regulation of cytokine production
GO:0002526 acute inflammatory response
GO:0002576 platelet degranulation
GO:0006887 exocytosis
GO:0006953 acute-phase response
GO:0032635 interleukin-6 production
GO:0032640 tumor necrosis factor production
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0045055 regulated exocytosis
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production
Molecular Function -
Cellular Component GO:0030141 secretory granule
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031983 vesicle lumen
GO:0034774 secretory granule lumen
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0072562 blood microparticle
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6798695: Neutrophil degranulation
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-114608: Platelet degranulation
R-HSA-76005: Response to elevated platelet cytosolic Ca2+
Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ORM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ORM1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.56 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ORM1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.1320.3
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6140.725
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)872.440.0855
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2810.808
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6930.686
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.5140.455
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2060.868
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.2310.501
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.9940.283
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7560.769
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.9240.57
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-1.0450.0376
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ORM1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ORM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ORM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ORM1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ORM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ORM1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ORM1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolORM1
Nameorosomucoid 1
Aliases AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ......
Chromosomal Location9q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ORM1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ORM1.
ID Name Drug Type Targets #Targets
DB00276AmsacrineSmall MoleculeALB, KCNH2, ORM1, TOP2A4
DB00281LidocaineSmall MoleculeEGFR, ORM1, ORM2, SCN10A, SCN4A, SCN5A, SCN9A7
DB00396ProgesteroneSmall MoleculeAR, CYP17A1, ESR1, NR1I2, NR3C1, NR3C2, OPRK1, ORM1, PGR, SHBG10
DB00477ChlorpromazineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CH ......31
DB00497OxycodoneSmall MoleculeOPRD1, OPRK1, OPRM1, ORM1, ORM25
DB00975DipyridamoleSmall MoleculeADA, ORM1, PDE10A, PDE4A, PDE5A, RCAN16
DB01041ThalidomideSmall MoleculeCRBN, FGFR2, NFKB1, ORM1, ORM2, PTGS2, TNF7