Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00061 Lipocalin / cytosolic fatty-acid binding protein family |
Function |
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0002526 acute inflammatory response GO:0002576 platelet degranulation GO:0006887 exocytosis GO:0006953 acute-phase response GO:0032635 interleukin-6 production GO:0032640 tumor necrosis factor production GO:0032675 regulation of interleukin-6 production GO:0032680 regulation of tumor necrosis factor production GO:0032715 negative regulation of interleukin-6 production GO:0032720 negative regulation of tumor necrosis factor production GO:0045055 regulated exocytosis GO:0071706 tumor necrosis factor superfamily cytokine production GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production |
Molecular Function | - |
Cellular Component |
GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0072562 blood microparticle GO:0099503 secretory vesicle |
KEGG | - |
Reactome |
R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+ |
Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ORM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ORM1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ORM1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ORM1 in various data sets.
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Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ORM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ORM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ORM1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ORM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ORM1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ORM1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ORM1 |
Name | orosomucoid 1 |
Aliases | AGP-A; HEL-S-153w; AGP 1; OMD 1; epididymis secretory sperm binding protein Li 153w; orosomucoid-1; Alpha-1- ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ORM1 collected from DrugBank database. |
Details on drugs targeting ORM1.
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