Summary | |
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Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF00041 Fibronectin type III domain |
Function |
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. |
Biological Process |
GO:0002526 acute inflammatory response GO:0002673 regulation of acute inflammatory response GO:0002675 positive regulation of acute inflammatory response GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0038165 oncostatin-M-mediated signaling pathway GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0004924 oncostatin-M receptor activity GO:0019838 growth factor binding |
Cellular Component |
GO:0005900 oncostatin-M receptor complex GO:0016324 apical plasma membrane GO:0043235 receptor complex GO:0045177 apical part of cell GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04151 PI3K-Akt signaling pathway hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-6788467: IL-6-type cytokine receptor ligand interactions R-HSA-168256: Immune System R-HSA-6783589: Interleukin-6 family signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
---|---|
Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between OSMR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of OSMR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of OSMR in various data sets.
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Points in the above scatter plot represent the mutation difference of OSMR in various data sets.
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Summary | |
---|---|
Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of OSMR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of OSMR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by OSMR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of OSMR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of OSMR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between OSMR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | OSMR |
Name | oncostatin M receptor |
Aliases | OSMRB; PLCA1; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 recepto ...... |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting OSMR collected from DrugBank database. |
There is no record. |