Summary | |
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Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain | - |
Function |
Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. |
Biological Process |
GO:0001101 response to acid chemical GO:0001501 skeletal system development GO:0001503 ossification GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001657 ureteric bud development GO:0001822 kidney development GO:0001823 mesonephros development GO:0001838 embryonic epithelial tube formation GO:0002028 regulation of sodium ion transport GO:0002062 chondrocyte differentiation GO:0003002 regionalization GO:0006814 sodium ion transport GO:0006970 response to osmotic stress GO:0007231 osmosensory signaling pathway GO:0007369 gastrulation GO:0007379 segment specification GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007498 mesoderm development GO:0007507 heart development GO:0007548 sex differentiation GO:0008406 gonad development GO:0009952 anterior/posterior pattern specification GO:0009954 proximal/distal pattern formation GO:0010463 mesenchymal cell proliferation GO:0010470 regulation of gastrulation GO:0010766 negative regulation of sodium ion transport GO:0010959 regulation of metal ion transport GO:0015672 monovalent inorganic cation transport GO:0016331 morphogenesis of embryonic epithelium GO:0018107 peptidyl-threonine phosphorylation GO:0018210 peptidyl-threonine modification GO:0022898 regulation of transmembrane transporter activity GO:0023016 signal transduction by trans-phosphorylation GO:0030278 regulation of ossification GO:0030282 bone mineralization GO:0030326 embryonic limb morphogenesis GO:0030500 regulation of bone mineralization GO:0030501 positive regulation of bone mineralization GO:0030856 regulation of epithelial cell differentiation GO:0030857 negative regulation of epithelial cell differentiation GO:0031214 biomineral tissue development GO:0032409 regulation of transporter activity GO:0032410 negative regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032413 negative regulation of ion transmembrane transporter activity GO:0032526 response to retinoic acid GO:0032835 glomerulus development GO:0034762 regulation of transmembrane transport GO:0034763 negative regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034766 negative regulation of ion transmembrane transport GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035115 embryonic forelimb morphogenesis GO:0035116 embryonic hindlimb morphogenesis GO:0035136 forelimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035282 segmentation GO:0035725 sodium ion transmembrane transport GO:0035850 epithelial cell differentiation involved in kidney development GO:0036022 limb joint morphogenesis GO:0036023 embryonic skeletal limb joint morphogenesis GO:0040019 positive regulation of embryonic development GO:0042471 ear morphogenesis GO:0042474 middle ear morphogenesis GO:0042476 odontogenesis GO:0042733 embryonic digit morphogenesis GO:0043271 negative regulation of ion transport GO:0043583 ear development GO:0045137 development of primary sexual characteristics GO:0045778 positive regulation of ossification GO:0045995 regulation of embryonic development GO:0048389 intermediate mesoderm development GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048736 appendage development GO:0048745 smooth muscle tissue development GO:0048762 mesenchymal cell differentiation GO:0048793 pronephros development GO:0048863 stem cell differentiation GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0051051 negative regulation of transport GO:0051216 cartilage development GO:0060021 palate development GO:0060173 limb development GO:0060272 embryonic skeletal joint morphogenesis GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060562 epithelial tube morphogenesis GO:0060993 kidney morphogenesis GO:0061004 pattern specification involved in kidney development GO:0061005 cell differentiation involved in kidney development GO:0061227 pattern specification involved in mesonephros development GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0061437 renal system vasculature development GO:0061440 kidney vasculature development GO:0061448 connective tissue development GO:0061458 reproductive system development GO:0070167 regulation of biomineral tissue development GO:0070169 positive regulation of biomineral tissue development GO:0071214 cellular response to abiotic stimulus GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid GO:0071470 cellular response to osmotic stress GO:0072001 renal system development GO:0072006 nephron development GO:0072007 mesangial cell differentiation GO:0072009 nephron epithelium development GO:0072012 glomerulus vasculature development GO:0072028 nephron morphogenesis GO:0072047 proximal/distal pattern formation involved in nephron development GO:0072048 renal system pattern specification GO:0072071 kidney interstitial fibroblast differentiation GO:0072073 kidney epithelium development GO:0072074 kidney mesenchyme development GO:0072075 metanephric mesenchyme development GO:0072078 nephron tubule morphogenesis GO:0072079 nephron tubule formation GO:0072080 nephron tubule development GO:0072081 specification of nephron tubule identity GO:0072087 renal vesicle development GO:0072088 nephron epithelium morphogenesis GO:0072098 anterior/posterior pattern specification involved in kidney development GO:0072111 cell proliferation involved in kidney development GO:0072131 kidney mesenchyme morphogenesis GO:0072132 mesenchyme morphogenesis GO:0072133 metanephric mesenchyme morphogenesis GO:0072141 renal interstitial fibroblast development GO:0072143 mesangial cell development GO:0072160 nephron tubule epithelial cell differentiation GO:0072161 mesenchymal cell differentiation involved in kidney development GO:0072162 metanephric mesenchymal cell differentiation GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072165 anterior mesonephric tubule development GO:0072166 posterior mesonephric tubule development GO:0072167 specification of mesonephric tubule identity GO:0072168 specification of anterior mesonephric tubule identity GO:0072169 specification of posterior mesonephric tubule identity GO:0072170 metanephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0072172 mesonephric tubule formation GO:0072175 epithelial tube formation GO:0072176 nephric duct development GO:0072177 mesonephric duct development GO:0072178 nephric duct morphogenesis GO:0072180 mesonephric duct morphogenesis GO:0072182 regulation of nephron tubule epithelial cell differentiation GO:0072183 negative regulation of nephron tubule epithelial cell differentiation GO:0072184 renal vesicle progenitor cell differentiation GO:0072185 metanephric cap development GO:0072186 metanephric cap morphogenesis GO:0072189 ureter development GO:0072190 ureter urothelium development GO:0072194 kidney smooth muscle tissue development GO:0072202 cell differentiation involved in metanephros development GO:0072203 cell proliferation involved in metanephros development GO:0072207 metanephric epithelium development GO:0072208 metanephric smooth muscle tissue development GO:0072210 metanephric nephron development GO:0072224 metanephric glomerulus development GO:0072234 metanephric nephron tubule development GO:0072239 metanephric glomerulus vasculature development GO:0072243 metanephric nephron epithelium development GO:0072258 metanephric interstitial fibroblast differentiation GO:0072259 metanephric interstitial fibroblast development GO:0072268 pattern specification involved in metanephros development GO:0072498 embryonic skeletal joint development GO:0090094 metanephric cap mesenchymal cell proliferation involved in metanephros development GO:0090183 regulation of kidney development GO:0090185 negative regulation of kidney development GO:0090596 sensory organ morphogenesis GO:1902305 regulation of sodium ion transmembrane transport GO:1902306 negative regulation of sodium ion transmembrane transport GO:1904062 regulation of cation transmembrane transport GO:1904063 negative regulation of cation transmembrane transport GO:1904238 pericyte cell differentiation GO:1905407 regulation of creatine transmembrane transporter activity GO:1905408 negative regulation of creatine transmembrane transporter activity GO:2000543 positive regulation of gastrulation GO:2000649 regulation of sodium ion transmembrane transporter activity GO:2000650 negative regulation of sodium ion transmembrane transporter activity GO:2000696 regulation of epithelial cell differentiation involved in kidney development GO:2000697 negative regulation of epithelial cell differentiation involved in kidney development GO:2001012 mesenchymal cell differentiation involved in renal system development |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity |
Cellular Component |
GO:0019898 extrinsic component of membrane |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between OSR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of OSR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of OSR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of OSR1 in various data sets.
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Summary | |
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Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of OSR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of OSR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by OSR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of OSR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of OSR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between OSR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | OSR1 |
Name | odd-skipped related transciption factor 1 |
Aliases | odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ...... |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting OSR1 collected from DrugBank database. |
There is no record. |