Summary | |
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Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain | - |
Function |
- |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0001654 eye development GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001822 kidney development GO:0001823 mesonephros development GO:0002062 chondrocyte differentiation GO:0007369 gastrulation GO:0007423 sensory organ development GO:0010470 regulation of gastrulation GO:0030278 regulation of ossification GO:0030282 bone mineralization GO:0030326 embryonic limb morphogenesis GO:0030500 regulation of bone mineralization GO:0030501 positive regulation of bone mineralization GO:0031214 biomineral tissue development GO:0033687 osteoblast proliferation GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035115 embryonic forelimb morphogenesis GO:0035116 embryonic hindlimb morphogenesis GO:0035136 forelimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0036022 limb joint morphogenesis GO:0036023 embryonic skeletal limb joint morphogenesis GO:0040019 positive regulation of embryonic development GO:0042471 ear morphogenesis GO:0042474 middle ear morphogenesis GO:0042476 odontogenesis GO:0042733 embryonic digit morphogenesis GO:0043010 camera-type eye development GO:0043583 ear development GO:0045778 positive regulation of ossification GO:0045995 regulation of embryonic development GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048736 appendage development GO:0048793 pronephros development GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0051216 cartilage development GO:0060021 palate development GO:0060173 limb development GO:0060272 embryonic skeletal joint morphogenesis GO:0060348 bone development GO:0060349 bone morphogenesis GO:0061029 eyelid development in camera-type eye GO:0061448 connective tissue development GO:0070167 regulation of biomineral tissue development GO:0070169 positive regulation of biomineral tissue development GO:0072001 renal system development GO:0072498 embryonic skeletal joint development GO:0090596 sensory organ morphogenesis GO:2000543 positive regulation of gastrulation |
Molecular Function |
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between OSR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of OSR2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of OSR2 in various data sets.
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Points in the above scatter plot represent the mutation difference of OSR2 in various data sets.
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Summary | |
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Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of OSR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of OSR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by OSR2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of OSR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of OSR2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between OSR2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | OSR2 |
Name | odd-skipped related transciption factor 2 |
Aliases | FLJ90037; odd-skipped related 2 (Drosophila); odd-skipped related 2; Protein odd-skipped-related 2 |
Chromosomal Location | 8q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting OSR2 collected from DrugBank database. |
There is no record. |