Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF01144 Coenzyme A transferase |
Function |
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). |
Biological Process |
GO:0044282 small molecule catabolic process GO:0046950 cellular ketone body metabolic process GO:0046952 ketone body catabolic process GO:1902224 ketone body metabolic process |
Molecular Function |
GO:0008260 3-oxoacid CoA-transferase activity GO:0008410 CoA-transferase activity GO:0016782 transferase activity, transferring sulfur-containing groups |
Cellular Component |
GO:0005929 cilium GO:0031514 motile cilium |
KEGG |
hsa00072 Synthesis and degradation of ketone bodies hsa00280 Valine, leucine and isoleucine degradation hsa00650 Butanoate metabolism |
Reactome | - |
Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between OXCT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of OXCT2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of OXCT2 in various data sets.
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Points in the above scatter plot represent the mutation difference of OXCT2 in various data sets.
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Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of OXCT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of OXCT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by OXCT2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of OXCT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of OXCT2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between OXCT2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | OXCT2 |
Name | 3-oxoacid CoA transferase 2 |
Aliases | FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting OXCT2 collected from DrugBank database. |
Details on drugs targeting OXCT2.
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