Browse OXCT2

Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion
Domain PF01144 Coenzyme A transferase
Function

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).

> Gene Ontology
 
Biological Process GO:0044282 small molecule catabolic process
GO:0046950 cellular ketone body metabolic process
GO:0046952 ketone body catabolic process
GO:1902224 ketone body metabolic process
Molecular Function GO:0008260 3-oxoacid CoA-transferase activity
GO:0008410 CoA-transferase activity
GO:0016782 transferase activity, transferring sulfur-containing groups
Cellular Component GO:0005929 cilium
GO:0031514 motile cilium
> KEGG and Reactome Pathway
 
KEGG hsa00072 Synthesis and degradation of ketone bodies
hsa00280 Valine, leucine and isoleucine degradation
hsa00650 Butanoate metabolism
Reactome -
Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between OXCT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of OXCT2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of OXCT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6690.0347
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.7010.237
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6450.186
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2270.552
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5940.586
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2390.852
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.130.761
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1690.808
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4740.523
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4690.248
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.4690.445
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2970.121
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of OXCT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of OXCT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of OXCT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by OXCT2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of OXCT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of OXCT2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between OXCT2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolOXCT2
Name3-oxoacid CoA transferase 2
Aliases FKSG25; FLJ00030; SCOT-T; SCOTT; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3- ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting OXCT2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting OXCT2.
ID Name Drug Type Targets #Targets
DB00139Succinic acidSmall MoleculeALDH5A1, ASPH, BBOX1, HSD17B6, OXCT1, OXCT2, P3H1, P3H2, P3H3, P4H ......26