Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum lumen |
Domain |
PF13640 2OG-Fe(II) oxygenase superfamily PF08336 Prolyl 4-Hydroxylase alpha-subunit |
Function |
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. |
Biological Process |
GO:0018126 protein hydroxylation GO:0018208 peptidyl-proline modification GO:0019511 peptidyl-proline hydroxylation |
Molecular Function |
GO:0004656 procollagen-proline 4-dioxygenase activity GO:0005506 iron ion binding GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0019798 procollagen-proline dioxygenase activity GO:0019842 vitamin binding GO:0031406 carboxylic acid binding GO:0031418 L-ascorbic acid binding GO:0031543 peptidyl-proline dioxygenase activity GO:0031545 peptidyl-proline 4-dioxygenase activity GO:0043168 anion binding GO:0051213 dioxygenase activity |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen |
KEGG |
hsa00330 Arginine and proline metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization |
Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between P4HA3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of P4HA3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of P4HA3 in various data sets.
|
Points in the above scatter plot represent the mutation difference of P4HA3 in various data sets.
|
Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of P4HA3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of P4HA3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by P4HA3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of P4HA3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of P4HA3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between P4HA3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | P4HA3 |
Name | prolyl 4-hydroxylase, alpha polypeptide III |
Aliases | C-P4Halpha(III); collagen prolyl 4-hydroxylase alpha(III); procollagen-proline, 2-oxoglutarate 4-dioxygenase ...... |
Chromosomal Location | 11q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting P4HA3 collected from DrugBank database. |
There is no record. |