Browse PACSIN2

Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cytoplasm, cytoskeleton Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Domain PF00611 Fes/CIP4
PF00018 SH3 domain
Function

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.

> Gene Ontology
 
Biological Process GO:0001765 membrane raft assembly
GO:0007009 plasma membrane organization
GO:0030100 regulation of endocytosis
GO:0031579 membrane raft organization
GO:0036010 protein localization to endosome
GO:0044091 membrane biogenesis
GO:0044854 plasma membrane raft assembly
GO:0044857 plasma membrane raft organization
GO:0045806 negative regulation of endocytosis
GO:0051051 negative regulation of transport
GO:0060627 regulation of vesicle-mediated transport
GO:0070836 caveola assembly
GO:0071709 membrane assembly
GO:0072584 caveolin-mediated endocytosis
GO:0072665 protein localization to vacuole
GO:0097320 membrane tubulation
Molecular Function GO:0043168 anion binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0070300 phosphatidic acid binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0001726 ruffle
GO:0005769 early endosome
GO:0005901 caveola
GO:0005913 cell-cell adherens junction
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0010008 endosome membrane
GO:0019898 extrinsic component of membrane
GO:0030055 cell-substrate junction
GO:0030659 cytoplasmic vesicle membrane
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0032587 ruffle membrane
GO:0044440 endosomal part
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0098589 membrane region
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-8856828: Clathrin-mediated endocytosis
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PACSIN2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PACSIN2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PACSIN2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.240.426
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3980.884
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1240.951
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0440.901
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2560.903
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4220.874
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2950.506
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3770.853
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2290.919
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3710.812
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.910.694
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0990.0948
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PACSIN2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PACSIN2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PACSIN2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PACSIN2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PACSIN2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PACSIN2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PACSIN2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPACSIN2
Nameprotein kinase C and casein kinase substrate in neurons 2
Aliases SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location22q13.2-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PACSIN2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.