Summary | |
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Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF00786 P21-Rho-binding domain PF00069 Protein kinase domain |
Function |
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. |
Biological Process |
GO:0000187 activation of MAPK activity GO:0001667 ameboidal-type cell migration GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0007015 actin filament organization GO:0007159 leukocyte cell-cell adhesion GO:0007409 axonogenesis GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0010720 positive regulation of cell development GO:0010761 fibroblast migration GO:0010762 regulation of fibroblast migration GO:0010763 positive regulation of fibroblast migration GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0016358 dendrite development GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022604 regulation of cell morphogenesis GO:0030041 actin filament polymerization GO:0030335 positive regulation of cell migration GO:0030832 regulation of actin filament length GO:0030833 regulation of actin filament polymerization GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031346 positive regulation of cell projection organization GO:0031349 positive regulation of defense response GO:0032147 activation of protein kinase activity GO:0032271 regulation of protein polymerization GO:0032535 regulation of cellular component size GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033674 positive regulation of kinase activity GO:0040017 positive regulation of locomotion GO:0042110 T cell activation GO:0043254 regulation of protein complex assembly GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045666 positive regulation of neuron differentiation GO:0045785 positive regulation of cell adhesion GO:0045860 positive regulation of protein kinase activity GO:0048013 ephrin receptor signaling pathway GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048813 dendrite morphogenesis GO:0048814 regulation of dendrite morphogenesis GO:0050769 positive regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0050775 positive regulation of dendrite morphogenesis GO:0050808 synapse organization GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051258 protein polymerization GO:0051272 positive regulation of cellular component movement GO:0051402 neuron apoptotic process GO:0051493 regulation of cytoskeleton organization GO:0051962 positive regulation of nervous system development GO:0060996 dendritic spine development GO:0060997 dendritic spine morphogenesis GO:0060998 regulation of dendritic spine development GO:0060999 positive regulation of dendritic spine development GO:0061001 regulation of dendritic spine morphogenesis GO:0061003 positive regulation of dendritic spine morphogenesis GO:0061564 axon development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070997 neuron death GO:0071407 cellular response to organic cyclic compound GO:0071593 lymphocyte aggregation GO:0071897 DNA biosynthetic process GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090066 regulation of anatomical structure size GO:0097061 dendritic spine organization GO:1900006 positive regulation of dendrite development GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:2000147 positive regulation of cell motility GO:2000278 regulation of DNA biosynthetic process GO:2000573 positive regulation of DNA biosynthetic process |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0004708 MAP kinase kinase activity GO:0004712 protein serine/threonine/tyrosine kinase activity GO:0005057 receptor signaling protein activity GO:0017016 Ras GTPase binding GO:0017048 Rho GTPase binding GO:0017124 SH3 domain binding GO:0031267 small GTPase binding GO:0051020 GTPase binding |
Cellular Component | - |
KEGG |
hsa04012 ErbB signaling pathway hsa04014 Ras signaling pathway hsa04360 Axon guidance hsa04510 Focal adhesion hsa04660 T cell receptor signaling pathway hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-428540: Activation of Rac R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5621575: CD209 (DC-SIGN) signaling R-HSA-389356: CD28 co-stimulation R-HSA-389359: CD28 dependent Vav1 pathway R-HSA-388841: Costimulation by the CD28 family R-HSA-1266738: Developmental Biology R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928664: Ephrin signaling R-HSA-202433: Generation of second messenger molecules R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-5683057: MAPK family signaling cascades R-HSA-5687128: MAPK6/MAPK4 signaling R-HSA-195258: RHO GTPase Effectors R-HSA-5627123: RHO GTPases activate PAKs R-HSA-399954: Sema3A PAK dependent Axon repulsion R-HSA-373755: Semaphorin interactions R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-376176: Signaling by Robo receptor R-HSA-194138: Signaling by VEGF R-HSA-202403: TCR signaling R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218920: VEGFR2 mediated vascular permeability |
Summary | |
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Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PAK3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PAK3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PAK3 in various data sets.
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Points in the above scatter plot represent the mutation difference of PAK3 in various data sets.
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Summary | |
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Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PAK3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PAK3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PAK3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PAK3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PAK3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PAK3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PAK3 |
Name | p21 protein (Cdc42/Rac)-activated kinase 3 |
Aliases | hPAK3; bPAK; MRX30; MRX47; mental retardation, X-linked 47; p21 (CDKN1A)-activated kinase 3; OPHN3; PAK-3bet ...... |
Chromosomal Location | Xq22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PAK3 collected from DrugBank database. |
There is no record. |