Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 3: Secreted. Note=Secreted from secretory granules.; SUBCELLULAR LOCATION: Isoform 4: Secreted. Note=Secreted from secretory granules. |
Domain |
PF03712 Copper type II ascorbate-dependent monooxygenase PF01082 Copper type II ascorbate-dependent monooxygenase PF01436 NHL repeat |
Function |
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. |
Biological Process |
GO:0001519 peptide amidation GO:0001666 response to hypoxia GO:0001676 long-chain fatty acid metabolic process GO:0006631 fatty acid metabolic process GO:0007507 heart development GO:0007565 female pregnancy GO:0007589 body fluid secretion GO:0007595 lactation GO:0009268 response to pH GO:0009306 protein secretion GO:0009404 toxin metabolic process GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0018032 protein amidation GO:0019748 secondary metabolic process GO:0022602 ovulation cycle process GO:0030879 mammary gland development GO:0031179 peptide modification GO:0031960 response to corticosteroid GO:0032355 response to estradiol GO:0032941 secretion by tissue GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0036293 response to decreased oxygen levels GO:0042476 odontogenesis GO:0042493 response to drug GO:0042698 ovulation cycle GO:0044706 multi-multicellular organism process GO:0046688 response to copper ion GO:0048511 rhythmic process GO:0048545 response to steroid hormone GO:0048732 gland development GO:0048736 appendage development GO:0050708 regulation of protein secretion GO:0050878 regulation of body fluid levels GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051384 response to glucocorticoid GO:0051493 regulation of cytoskeleton organization GO:0060135 maternal process involved in female pregnancy GO:0060173 limb development GO:0070482 response to oxygen levels GO:1990267 response to transition metal nanoparticle |
Molecular Function |
GO:0004497 monooxygenase activity GO:0004504 peptidylglycine monooxygenase activity GO:0004598 peptidylamidoglycolate lyase activity GO:0005507 copper ion binding GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen GO:0016829 lyase activity GO:0016840 carbon-nitrogen lyase activity GO:0016842 amidine-lyase activity GO:0019842 vitamin binding GO:0031406 carboxylic acid binding GO:0031418 L-ascorbic acid binding GO:0043168 anion binding |
Cellular Component |
GO:0005802 trans-Golgi network GO:0030141 secretory granule GO:0030659 cytoplasmic vesicle membrane GO:0030667 secretory granule membrane GO:0031984 organelle subcompartment GO:0043025 neuronal cell body GO:0043204 perikaryon GO:0044297 cell body GO:0098791 Golgi subcompartment GO:0099503 secretory vesicle |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PAM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PAM in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PAM in various data sets.
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Points in the above scatter plot represent the mutation difference of PAM in various data sets.
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Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PAM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PAM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PAM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PAM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PAM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PAM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PAM |
Name | peptidylglycine alpha-amidating monooxygenase |
Aliases | PHM; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine alpha-hydroxylating monooxygenase; ...... |
Chromosomal Location | 5q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PAM collected from DrugBank database. |
Details on drugs targeting PAM.
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