Summary | |
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Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00066 LNR domain PF05572 Pregnancy-associated plasma protein-A PF00084 Sushi repeat (SCR repeat) |
Function |
Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. |
Biological Process |
GO:0001501 skeletal system development GO:0001558 regulation of cell growth GO:0016049 cell growth GO:0048705 skeletal system morphogenesis GO:0060348 bone development GO:0060349 bone morphogenesis |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0008237 metallopeptidase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Summary | |
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Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PAPPA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PAPPA2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PAPPA2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PAPPA2 in various data sets.
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Summary | |
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Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PAPPA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PAPPA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PAPPA2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PAPPA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PAPPA2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PAPPA2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PAPPA2 |
Name | pappalysin 2 |
Aliases | PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ...... |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PAPPA2 collected from DrugBank database. |
There is no record. |