Browse PAPPA2

Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF00066 LNR domain
PF05572 Pregnancy-associated plasma protein-A
PF00084 Sushi repeat (SCR repeat)
Function

Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001558 regulation of cell growth
GO:0016049 cell growth
GO:0048705 skeletal system morphogenesis
GO:0060348 bone development
GO:0060349 bone morphogenesis
Molecular Function GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PAPPA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PAPPA2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PAPPA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0770.882
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5210.71
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.480.772
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2390.778
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5040.735
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0370.982
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2330.757
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.10.921
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0680.822
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PAPPA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141735.7035.70.0118
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103500500.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277322.29.612.60.107
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275922.210.2120.181
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211747.623.524.10.181
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.5037.50.209
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131153.836.417.40.444
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.212.59.70.602
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 382715.822.2-6.40.534
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.223.1-4.91
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.521.4-8.90.642
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PAPPA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PAPPA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PAPPA2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PAPPA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PAPPA2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PAPPA2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPAPPA2
Namepappalysin 2
Aliases PAPPE; PAPP-A2; PLAC3; placenta-specific 3; PAPP-E; pregnancy-associated plasma preproprotein-A2; pregnancy- ......
Chromosomal Location1q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PAPPA2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.