Browse PAX8

Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00292 'Paired box' domain
PF12403 Paired-box protein 2 C terminal
Function

Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001838 embryonic epithelial tube formation
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0003002 regionalization
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003338 metanephros morphogenesis
GO:0003339 regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006575 cellular modified amino acid metabolic process
GO:0006590 thyroid hormone generation
GO:0006790 sulfur compound metabolic process
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0009914 hormone transport
GO:0010092 specification of animal organ identity
GO:0010817 regulation of hormone levels
GO:0015833 peptide transport
GO:0016331 morphogenesis of embryonic epithelium
GO:0018958 phenol-containing compound metabolic process
GO:0019827 stem cell population maintenance
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030878 thyroid gland development
GO:0032350 regulation of hormone metabolic process
GO:0032352 positive regulation of hormone metabolic process
GO:0034698 response to gonadotropin
GO:0035019 somatic stem cell population maintenance
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035270 endocrine system development
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0038194 thyroid-stimulating hormone signaling pathway
GO:0039003 pronephric field specification
GO:0039017 pattern specification involved in pronephros development
GO:0042403 thyroid hormone metabolic process
GO:0042445 hormone metabolic process
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042886 amide transport
GO:0043583 ear development
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048645 animal organ formation
GO:0048732 gland development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048793 pronephros development
GO:0048839 inner ear development
GO:0060231 mesenchymal to epithelial transition
GO:0060561 apoptotic process involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060993 kidney morphogenesis
GO:0061004 pattern specification involved in kidney development
GO:0061005 cell differentiation involved in kidney development
GO:0061138 morphogenesis of a branching epithelium
GO:0061213 positive regulation of mesonephros development
GO:0061217 regulation of mesonephros development
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0070460 thyroid-stimulating hormone secretion
GO:0071371 cellular response to gonadotropin stimulus
GO:0071599 otic vesicle development
GO:0072001 renal system development
GO:0072003 kidney rudiment formation
GO:0072004 kidney field specification
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072017 distal tubule development
GO:0072025 distal convoluted tubule development
GO:0072028 nephron morphogenesis
GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis
GO:0072039 regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
GO:0072040 negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
GO:0072044 collecting duct development
GO:0072048 renal system pattern specification
GO:0072049 comma-shaped body morphogenesis
GO:0072050 S-shaped body morphogenesis
GO:0072069 DCT cell differentiation
GO:0072073 kidney epithelium development
GO:0072077 renal vesicle morphogenesis
GO:0072078 nephron tubule morphogenesis
GO:0072079 nephron tubule formation
GO:0072080 nephron tubule development
GO:0072087 renal vesicle development
GO:0072088 nephron epithelium morphogenesis
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072160 nephron tubule epithelial cell differentiation
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072170 metanephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072173 metanephric tubule morphogenesis
GO:0072174 metanephric tubule formation
GO:0072175 epithelial tube formation
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0072202 cell differentiation involved in metanephros development
GO:0072205 metanephric collecting duct development
GO:0072207 metanephric epithelium development
GO:0072210 metanephric nephron development
GO:0072215 regulation of metanephros development
GO:0072216 positive regulation of metanephros development
GO:0072217 negative regulation of metanephros development
GO:0072221 metanephric distal convoluted tubule development
GO:0072234 metanephric nephron tubule development
GO:0072235 metanephric distal tubule development
GO:0072240 metanephric DCT cell differentiation
GO:0072243 metanephric nephron epithelium development
GO:0072257 metanephric nephron tubule epithelial cell differentiation
GO:0072273 metanephric nephron morphogenesis
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072282 metanephric nephron tubule morphogenesis
GO:0072283 metanephric renal vesicle morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072289 metanephric nephron tubule formation
GO:0072304 regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072305 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:0072309 mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
GO:0090087 regulation of peptide transport
GO:0090183 regulation of kidney development
GO:0090184 positive regulation of kidney development
GO:0090185 negative regulation of kidney development
GO:0090189 regulation of branching involved in ureteric bud morphogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090276 regulation of peptide hormone secretion
GO:0090596 sensory organ morphogenesis
GO:0097152 mesenchymal cell apoptotic process
GO:0098727 maintenance of cell number
GO:1900200 mesenchymal cell apoptotic process involved in metanephros development
GO:1900204 apoptotic process involved in metanephric collecting duct development
GO:1900205 apoptotic process involved in metanephric nephron tubule development
GO:1900211 regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900214 regulation of apoptotic process involved in metanephric collecting duct development
GO:1900215 negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900217 regulation of apoptotic process involved in metanephric nephron tubule development
GO:1900218 negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:1901145 mesenchymal cell apoptotic process involved in nephron morphogenesis
GO:1901147 mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:1901615 organic hydroxy compound metabolic process
GO:1902337 regulation of apoptotic process involved in morphogenesis
GO:1902338 negative regulation of apoptotic process involved in morphogenesis
GO:1902455 negative regulation of stem cell population maintenance
GO:1902742 apoptotic process involved in development
GO:1904672 regulation of somatic stem cell population maintenance
GO:1904673 negative regulation of somatic stem cell population maintenance
GO:1904746 negative regulation of apoptotic process involved in development
GO:1904748 regulation of apoptotic process involved in development
GO:1905330 regulation of morphogenesis of an epithelium
GO:1905332 positive regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
GO:2000036 regulation of stem cell population maintenance
GO:2000592 regulation of metanephric DCT cell differentiation
GO:2000594 positive regulation of metanephric DCT cell differentiation
GO:2000609 regulation of thyroid hormone generation
GO:2000611 positive regulation of thyroid hormone generation
GO:2000612 regulation of thyroid-stimulating hormone secretion
GO:2000696 regulation of epithelial cell differentiation involved in kidney development
GO:2000698 positive regulation of epithelial cell differentiation involved in kidney development
GO:2001053 regulation of mesenchymal cell apoptotic process
GO:2001054 negative regulation of mesenchymal cell apoptotic process
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0004996 thyroid-stimulating hormone receptor activity
GO:0016500 protein-hormone receptor activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04918 Thyroid hormone synthesis
Reactome -
Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PAX8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PAX8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PAX8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5650.113
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0710.908
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.0510.0151
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6860.264
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8320.706
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.50.858
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1690.752
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1520.848
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2720.749
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3250.871
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0810.977
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-1.0020.0363
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PAX8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PAX8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PAX8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PAX8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PAX8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PAX8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PAX8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPAX8
Namepaired box 8
Aliases paired box gene 8; paired domain gene 8; Paired box protein Pax-8
Chromosomal Location2q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PAX8 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.