Summary | |
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Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. |
Domain |
PF00013 KH domain |
Function |
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). ; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000398 mRNA splicing, via spliceosome GO:0001818 negative regulation of cytokine production GO:0002181 cytoplasmic translation GO:0002183 cytoplasmic translational initiation GO:0002190 cap-independent translational initiation GO:0002192 IRES-dependent translational initiation GO:0002683 negative regulation of immune system process GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002831 regulation of response to biotic stimulus GO:0002832 negative regulation of response to biotic stimulus GO:0006397 mRNA processing GO:0006413 translational initiation GO:0008380 RNA splicing GO:0009615 response to virus GO:0010498 proteasomal protein catabolic process GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0019080 viral gene expression GO:0019081 viral translation GO:0031348 negative regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0032479 regulation of type I interferon production GO:0032480 negative regulation of type I interferon production GO:0032606 type I interferon production GO:0039694 viral RNA genome replication GO:0039703 RNA replication GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044033 multi-organism metabolic process GO:0048525 negative regulation of viral process GO:0050687 negative regulation of defense response to virus GO:0050688 regulation of defense response to virus GO:0050792 regulation of viral process GO:0051607 defense response to virus GO:0075522 IRES-dependent viral translational initiation GO:0098542 defense response to other organism |
Molecular Function |
GO:0003697 single-stranded DNA binding GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding GO:1990829 C-rich single-stranded DNA binding |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-936440: Negative regulators of RIG-I/MDA5 signaling R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-72172: mRNA Splicing R-HSA-72163: mRNA Splicing - Major Pathway |
Summary | |
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Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PCBP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PCBP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PCBP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PCBP2 in various data sets.
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Summary | |
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Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PCBP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PCBP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PCBP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PCBP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PCBP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PCBP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PCBP2 |
Name | poly(rC) binding protein 2 |
Aliases | HNRPE2; hnRNP-E2; HNRNPE2; heterogenous nuclear ribonucleoprotein E2; poly(rC)-binding protein 2; alpha-CP2; ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PCBP2 collected from DrugBank database. |
There is no record. |