Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF00821 Phosphoenolpyruvate carboxykinase character(0) character(0) |
Function |
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. |
Biological Process |
GO:0001101 response to acid chemical GO:0001666 response to hypoxia GO:0002237 response to molecule of bacterial origin GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006066 alcohol metabolic process GO:0006071 glycerol metabolic process GO:0006090 pyruvate metabolic process GO:0006094 gluconeogenesis GO:0006107 oxaloacetate metabolic process GO:0006114 glycerol biosynthetic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0007568 aging GO:0009132 nucleoside diphosphate metabolic process GO:0009267 cellular response to starvation GO:0009268 response to pH GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009750 response to fructose GO:0009991 response to extracellular stimulus GO:0010447 response to acidic pH GO:0014074 response to purine-containing compound GO:0014823 response to activity GO:0016051 carbohydrate biosynthetic process GO:0019318 hexose metabolic process GO:0019319 hexose biosynthetic process GO:0019400 alditol metabolic process GO:0019401 alditol biosynthetic process GO:0019432 triglyceride biosynthetic process GO:0019751 polyol metabolic process GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0032496 response to lipopolysaccharide GO:0032526 response to retinoic acid GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033500 carbohydrate homeostasis GO:0033762 response to glucagon GO:0034284 response to monosaccharide GO:0034612 response to tumor necrosis factor GO:0034637 cellular carbohydrate biosynthetic process GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0042593 glucose homeostasis GO:0042594 response to starvation GO:0043200 response to amino acid GO:0043434 response to peptide hormone GO:0043543 protein acylation GO:0043648 dicarboxylic acid metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0045017 glycerolipid biosynthetic process GO:0046165 alcohol biosynthetic process GO:0046173 polyol biosynthetic process GO:0046327 glycerol biosynthetic process from pyruvate GO:0046364 monosaccharide biosynthetic process GO:0046460 neutral lipid biosynthetic process GO:0046463 acylglycerol biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046683 response to organophosphorus GO:0046939 nucleotide phosphorylation GO:0051365 cellular response to potassium ion starvation GO:0051591 response to cAMP GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH GO:0070482 response to oxygen levels GO:0070555 response to interleukin-1 GO:0070741 response to interleukin-6 GO:0071214 cellular response to abiotic stimulus GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071320 cellular response to cAMP GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071332 cellular response to fructose stimulus GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071375 cellular response to peptide hormone stimulus GO:0071377 cellular response to glucagon stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071467 cellular response to pH GO:0071468 cellular response to acidic pH GO:0071496 cellular response to external stimulus GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1904640 response to methionine |
Molecular Function |
GO:0000287 magnesium ion binding GO:0004550 nucleoside diphosphate kinase activity GO:0004611 phosphoenolpyruvate carboxykinase activity GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity GO:0005525 GTP binding GO:0016776 phosphotransferase activity, phosphate group as acceptor GO:0016829 lyase activity GO:0016830 carbon-carbon lyase activity GO:0016831 carboxy-lyase activity GO:0019001 guanyl nucleotide binding GO:0019003 GDP binding GO:0019205 nucleobase-containing compound kinase activity GO:0030145 manganese ion binding GO:0031406 carboxylic acid binding GO:0032561 guanyl ribonucleotide binding GO:0043168 anion binding |
Cellular Component | - |
KEGG |
hsa03320 PPAR signaling pathway hsa04068 FoxO signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04910 Insulin signaling pathway hsa04920 Adipocytokine signaling pathway hsa04922 Glucagon signaling pathway hsa04964 Proximal tubule bicarbonate reclamation hsa00010 Glycolysis / Gluconeogenesis hsa00020 Citrate cycle (TCA cycle) hsa00620 Pyruvate metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-2161541: Abacavir metabolism R-HSA-2161522: Abacavir transport and metabolism R-HSA-1266738: Developmental Biology R-HSA-70263: Gluconeogenesis R-HSA-70326: Glucose metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-381340: Transcriptional regulation of white adipocyte differentiation |
Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PCK1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PCK1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PCK1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PCK1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PCK1 in various data sets.
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Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PCK1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PCK1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PCK1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PCK1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PCK1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PCK1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PCK1 |
Name | phosphoenolpyruvate carboxykinase 1 (soluble) |
Aliases | PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; Phos ...... |
Chromosomal Location | 20q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PCK1 collected from DrugBank database. |
Details on drugs targeting PCK1.
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